Pulsar-wind nebulae and magnetar outflows: observations at radio, X-ray, and gamma-ray wavelengths

We review observations of several classes of neutron-star-powered outflows: pulsar-wind nebulae (PWNe) inside shell supernova remnants (SNRs), PWNe interacting directly with interstellar medium (ISM), and magnetar-powered outflows. We describe radio, X-ray, and gamma-ray observations of PWNe, focusing first on integrated spectral-energy distributions (SEDs) and global spectral properties. High-resolution X-ray imaging of PWNe shows a bewildering array of morphologies, with jets, trails, and other structures. Several of the 23 so far identified magnetars show evidence for continuous or sporadic emission of material, sometimes associated with giant flares, and a few possible "magnetar-wind nebulae" have been recently identified.Comment: 61 pages, 44 figures (reduced in quality for size reasons). Published in Space Science Reviews, "Jets and Winds in Pulsar Wind Nebulae, Gamma-ray Bursts and Blazars: Physics of Extreme Energy Release

Implications of H.E.S.S. observations of pulsar wind nebulae

In this review paper on pulsar wind nebulae (PWN) we discuss the properties of such nebulae within the context of containment against cross-field diffusion (versus normal advection), the effect of reverse shocks on the evolution of offset ``Vela-like'' PWN, constraints on maximum particle energetics, magnetic field strength estimates based on spectral and spatial properties, and the implication of such field estimates on the composition of the wind. A significant part of the discussion is based on the High Energy Stereoscopic System ({\it H.E.S.S.} or {\it HESS}) detection of the two evolved pulsar wind nebulae Vela X (cocoon) and HESS J1825-137. In the case of Vela X (cocoon) we also review evidence of a hadronic versus a leptonic interpretation, showing that a leptonic interpretation is favored for the {\it HESS} signal. The constraints discussed in this review paper sets a general framework for the interpretation of a number of offset, filled-center nebulae seen by {\it HESS}. These sources are found along the galactic plane with galactic latitudes $|b|\sim 0$, where significant amounts of molecular gas is found. In these regions, we find that the interstellar medium is inhomogeneous, which has an effect on the morphology of supernova shock expansion. One consequence of this effect is the formation of offset pulsar wind nebulae as observed.Comment: to appear in Springer Lecture Notes on Neutron Stars and Pulsars: 40 years after their discovery, eds. W. Becke

Pulsar Wind Nebulae with Bow Shocks: Non-thermal Radiation and Cosmic Ray Leptons

Pulsars with high spin-down power produce relativistic winds radiating a non-negligible fraction of this power over the whole electromagnetic range from radio to gamma-rays in the pulsar wind nebulae (PWNe). The rest of the power is dissipated in the interactions of the PWNe with the ambient interstellar medium (ISM). Some of the PWNe are moving relative to the ambient ISM with supersonic speeds producing bow shocks. In this case, the ultrarelativistic particles accelerated at the termination surface of the pulsar wind may undergo reacceleration in the converging flow system formed by the plasma outflowing from the wind termination shock and the plasma inflowing from the bow shock. The presence of magnetic perturbations in the flow, produced by instabilities induced by the accelerated particles themselves, is essential for the process to work. A generic outcome of this type of reacceleration is the creation of particle distributions with very hard spectra, such as are indeed required to explain the observed spectra of synchrotron radiation with photon indices Γ≲ 1.5. The presence of this hard spectral component is specific to PWNe with bow shocks (BSPWNe). The accelerated particles, mainly electrons and positrons, may end up containing a substantial fraction of the shock ram pressure. In addition, for typical ISM and pulsar parameters, the e+ released by these systems in the Galaxy are numerous enough to contribute a substantial fraction of the positrons detected as cosmic ray (CR) particles above few tens of GeV and up to several hundred GeV. The escape of ultrarelativistic particles from a BSPWN—and hence, its appearance in the far-UV and X-ray bands—is determined by the relative directions of the interstellar magnetic field, the velocity of the astrosphere and the pulsar rotation axis. In this respect we review the observed appearance and multiwavelength spectra of three different types of BSPWNe: PSR J0437-4715, the Guitar and Lighthouse nebulae, and Vela-like objects. We argue that high resolution imaging of such objects provides unique information both on pulsar winds and on the ISM. We discuss the interpretation of imaging observations in the context of the model outlined above and estimate the BSPWN contribution to the positron flux observed at the Earth

Whole-genome sequencing reveals host factors underlying critical COVID-19

Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2,3,4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease

Deformation bands and the formation of grain boundaries in a superplastic aluminum alloy

Superplastic aluminum alloys are often classified according to the mechanism of microstructural transformation during annealing after deformation processing. In Al-Cu-Zr materials, such as Supral 2004, the presence of fine (10 to 50 nm) second-phase particles retards dislocation rearrangement and the formation and migration of boundaries during either annealing or elevated temperature deformation after thermomechanical processing. This leads to predominance of recovery in the evolution of microstructure, although high-angle boundaries must still form in order to account for the superplastic response of such materials. The mechanisms of high-angle boundary formation in such circumstances have remained unclear. The term “continuous recrystallization” (CRX) has been used as a phenomenological description of recovery-dominated processes that take place uniformly through- out the microstructure and lead to the formation of fine grains with high-angle boundaries. Orientation imaging microscopy (OIM) methods have been employed to assess the as-processed microstructure of this alloy and its evolution during annealing at 450 °C, as well as during superplastic deformation at this temperature. Orientation images demonstrate the presence of deformation bands of alternating lattice orientations that corresponds to the symmetric variants of the brass, or B, texture component ((112){110} in rolled material). During annealing, the high-angle grain boundaries (disorientation of 50 to 62.8 deg) develop from transition regions between such bands while the lower-angle boundaries (i.e., up to 20 deg) separate an evolving cell structure within the bands. Further OIM results show that the bands remain distinct features of the microstructure during either annealing alone or during deformation under superplastic conditions