Helical Tubes in Crowded Environments

When placed in a crowded environment, a semi-flexible tube is forced to fold so as to make a more compact shape. One compact shape that often arises in nature is the tight helix, especially when the tube thickness is of comparable size to the tube length. In this paper we use an excluded volume effect to model the effects of crowding. This gives us a measure of compactness for configurations of the tube, which we use to look at structures of the semi-flexible tube that minimize the excluded volume. We focus most of our attention on the helix and which helical geometries are most compact. We found that helices of specific pitch to radius ratio 2.512 to be optimally compact. This is the same geometry that minimizes the global curvature of the curve defining the tube. We further investigate the effects of adding a bending energy or multiple tubes to begin to explore the more complete space of possible geometries a tube could form.Comment: 10 page

Certification of Bounds of Non-linear Functions: the Templates Method

The aim of this work is to certify lower bounds for real-valued multivariate functions, defined by semialgebraic or transcendental expressions. The certificate must be, eventually, formally provable in a proof system such as Coq. The application range for such a tool is widespread; for instance Hales' proof of Kepler's conjecture yields thousands of inequalities. We introduce an approximation algorithm, which combines ideas of the max-plus basis method (in optimal control) and of the linear templates method developed by Manna et al. (in static analysis). This algorithm consists in bounding some of the constituents of the function by suprema of quadratic forms with a well chosen curvature. This leads to semialgebraic optimization problems, solved by sum-of-squares relaxations. Templates limit the blow up of these relaxations at the price of coarsening the approximation. We illustrate the efficiency of our framework with various examples from the literature and discuss the interfacing with Coq.Comment: 16 pages, 3 figures, 2 table

Dense sphere packings from optimized correlation functions

Elementary smooth functions (beyond contact) are employed to construct pair correlation functions that mimic jammed disordered sphere packings. Using the g2-invariant optimization method of Torquato and Stillinger [J. Phys. Chem. B 106, 8354, 2002], parameters in these functions are optimized under necessary realizability conditions to maximize the packing fraction phi and average number of contacts per sphere Z. A pair correlation function that incorporates the salient features of a disordered packing and that is smooth beyond contact is shown to permit a phi of 0.6850: this value represents a 45% reduction in the difference between the maximum for congruent hard spheres in three dimensions, pi/sqrt{18} ~ 0.7405, and 0.64, the approximate fraction associated with maximally random jammed (MRJ) packings in three dimensions. We show that, surprisingly, the continued addition of elementary functions consisting of smooth sinusoids decaying as r^{-4} permits packing fractions approaching pi/sqrt{18}. A translational order metric is used to discriminate between degrees of order in the packings presented. We find that to achieve higher packing fractions, the degree of order must increase, which is consistent with the results of a previous study [Torquato et al., Phys. Rev. Lett. 84, 2064, 2000].Comment: 26 pages, 9 figures, 1 table; added references, fixed typos, simplified argument and discussion in Section IV

Hormone-Induced 14-3-3γ Adaptor Protein Regulates Steroidogenic Acute Regulatory Protein Activity and Steroid Biosynthesis in MA-10 Leydig Cells

Cholesterol is the sole precursor of steroid hormones in the body. The import of cholesterol to the inner mitochondrial membrane, the rate-limiting step in steroid biosynthesis, relies on the formation of a protein complex that assembles at the outer mitochondrial membrane called the transduceosome. The transduceosome contains several mitochondrial and cytosolic components, including the steroidogenic acute regulatory protein (STAR). Human chorionic gonadotropin (hCG) induces de novo synthesis of STAR, a process shown to parallel maximal steroid production. In the hCG-dependent steroidogenic MA-10 mouse Leydig cell line, the 14-3-3γ protein was identified in native mitochondrial complexes by mass spectrometry and immunoblotting, and its levels increased in response to hCG treatment. The 14-3-3 proteins bind and regulate the activity of many proteins, acting via target protein activation, modification and localization. In MA-10 cells, cAMP induces 14-3-3γ expression parallel to STAR expression. Silencing of 14-3-3γ expression potentiates hormone-induced steroidogenesis. Binding motifs of 14-3-3γ were identified in components of the transduceosome, including STAR. Immunoprecipitation studies demonstrate a hormone-dependent interaction between 14-3-3γ and STAR that coincides with reduced 14-3-3γ homodimerization. The binding site of 14-3-3γ on STAR was identified to be Ser-194 in the STAR-related sterol binding lipid transfer (START) domain, the site phosphorylated in response to hCG. Taken together, these results demonstrate that 14-3-3γ negatively regulates steroidogenesis by binding to Ser-194 of STAR, thus keeping STAR in an unfolded state, unable to induce maximal steroidogenesis. Over time 14-3-3γ homodimerizes and dissociates from STAR, allowing this protein to induce maximal mitochondrial steroid formation

Alternative job search strategies in remote rural and peri-urban labour markets: the role of social networks

This paper examines the importance of informal methods (especially social networking) to the job search strategies used by unemployed people. It compares three areas: a small rural town; a larger, more sparsely populated, remote rural area; and a centrally-located, peri-urban labour market. The analysis is based first on survey research undertaken with 490 job seekers across the study areas. Emerging issues were then followed up during a series of twelve focus groups. The survey research showed that job seekers in the rural study areas were significantly more likely to use social networks to look for work. However, those who had experienced repeated or long-term periods out of work, the unskilled and young people were significantly less likely to use such networks. Focus groups confirmed the perceived importance of social networking to the job search process in rural areas, in contrast to the more marginal role such methods appear to play in peri-urban settings. For many rural job seekers, formal job search activities conducted through Jobcentres were seen as largely symbolic, lacking the practical value of social networking. These results suggest that service providers seeking to assist unemployed people in rural areas need to address the problems faced by many disadvantaged job seekers who are currently caught between their lack of social network relations and the absence of local public employment service facilities in more remote communities

The effect of a lumbopelvic compression belt on load transfer during the active straight leg test: A proof of concept study using ultrasound imaging

INTRODUCTION: The active straight leg raise (ASLR) test assesses load transfer through the pelvis. During the ASLR, intraabdominal pressure (IAP) rises, increasing the load on the lumbopelvic region. Several studies have shown a correlation between the magnitude of bladder base displacement (BBD) during the ASLR and lumbopelvic instability. Additionally, greater depression of the bladder and pelvic floor muscles is associated with motor control impairments associated with form and force closure. Pelvic stability belts are a common therapeutic intervention for individuals who report pelvic girdle pain. Their mechanism of action is to improve form closure and assist force closure and motor control. Impaired form and force closure mechanisms through the lumbopelvic area are associated poor load transfer, low back pain, sacroiliac pain, stress urinary incontinence and chronic pelvic pain. OBJECTIVES: This study aimed to observe and determine the impact of the ASLR test with and without a Serola lumbopelvic belt on BBD and participant self-reported level of difficulty score. METHODS: A convenience sample of fifteen physical therapy students (mean age 25 years) who were previously identified as having lumbopelvic instability were recruited for this study. PCOM\u27s institutional review board approved the study, and each participant provided informed consent. All participants completed a bladder filling protocol via natural diuresis to standardize bladder volumes to allow for bladder and pelvic floor delineation on ultrasound imaging. A Clarius C3 curvilinear wireless ultrasound unit was used for image acquisition with images displayed on an IPAD. The ultrasound transducer was placed suprapublically on the lower abdomen, oriented transversely, and manipulated until a clear image of the bladder base was apparent. A standard script was read to each participant to standardize testing. The magnitude of BBD was captured with cine loops across two testing conditions: the ASLR test without a lumbopelvic belt which was repeated with the participant wearing a belt. Participants also self-reported the level of difficulty for each testing condition. Participants were fitted with the lumbopelvic belt according to manufacturer’s recommendation. The belt tension was standardized using a manometer set to 20mmHG placed between the belt\u27s anterior aspect and the participant\u27s lower abdomen. On-screen calipers identified the lateral and medial aspects of the bladder base. All images were saved for post hoc analysis to determine the magnitude and direction of BBD between both testing conditions. RESULTS: Descriptive statistics will be reported, and a repeated measures ANOVA will be completed to determine whether there is a statistically significant difference between the means with the level of significance set at p=.05. CONCLUSION: TB

The VLA Low-frequency Sky Survey

The Very Large Array (VLA) Low-frequency Sky Survey (VLSS) has imaged 95% of the 3*pi sr of sky north of declination = -30 degrees at a frequency of 74 MHz (4 meter wavelength). The resolution is 80" (FWHM) throughout, and the typical RMS noise level is ~0.1 Jy/beam. The typical point-source detection limit is 0.7 Jy/beam and so far nearly 70,000 sources have been catalogued. This survey used the 74 MHz system added to the VLA in 1998. It required new imaging algorithms to remove the large ionospheric distortions at this very low frequency throughout the entire ~11.9 degree field of view. This paper describes the observation and data reduction methods used for the VLSS and presents the survey images and source catalog. All of the calibrated images and the source catalog are available online (http://lwa.nrl.navy.mil/VLSS) for use by the astronomical community.Comment: 53 pages, including 3 tables and 15 figures. Has been accepted for publication in the Astronomical Journa

Radio Frequency Spectra of 388 Bright 74 MHz Sources

As a service to the community, we have compiled radio frequency spectra from the literature for all sources within the VLA Low Frequency Sky Survey (VLSS) that are brighter than 15 Jy at 74 MHz. Over 160 references were used to maximize the amount of spectral data used in the compilation of the spectra, while also taking care to determine the corrections needed to put the flux densities from all reference on the same absolute flux density scale. With the new VLSS data, we are able to vastly improve upon previous efforts to compile spectra of bright radio sources to frequencies below 100 MHz because (1) the VLSS flux densities are more reliable than those from some previous low frequency surveys and (2) the VLSS covers a much larger area of the sky (declination >-30 deg.) than many other low frequency surveys (e.g., the 8C survey). In this paper, we discuss how the spectra were constructed and how parameters quantifying the shapes of the spectra were derived. Both the spectra and the shape parameters are made available here to assist in the calibration of observations made with current and future low frequency radio facilities.Comment: Accepted to ApJ

Observing the Sun with Atacama Large Millimeter/submillimeter Array (ALMA): High Resolution Interferometric Imaging

Observations of the Sun at millimeter and submillimeter wavelengths offer a unique probe into the structure, dynamics, and heating of the chromosphere; the structure of sunspots; the formation and eruption of prominences and filaments; and energetic phenomena such as jets and flares. High-resolution observations of the Sun at millimeter and submillimeter wavelengths are challenging due to the intense, extended, low- contrast, and dynamic nature of emission from the quiet Sun, and the extremely intense and variable nature of emissions associated with energetic phenomena. The Atacama Large Millimeter/submillimeter Array (ALMA) was designed with solar observations in mind. The requirements for solar observations are significantly different from observations of sidereal sources and special measures are necessary to successfully carry out this type of observations. We describe the commissioning efforts that enable the use of two frequency bands, the 3 mm band (Band 3) and the 1.25 mm band (Band 6), for continuum interferometric-imaging observations of the Sun with ALMA. Examples of high-resolution synthesized images obtained using the newly commissioned modes during the solar commissioning campaign held in December 2015 are presented. Although only 30 of the eventual 66 ALMA antennas were used for the campaign, the solar images synthesized from the ALMA commissioning data reveal new features of the solar atmosphere that demonstrate the potential power of ALMA solar observations. The ongoing expansion of ALMA and solar-commissioning efforts will continue to enable new and unique solar observing capabilities.Comment: 22 pages, 12 figures, accepted for publication in Solar Physic