Estrategias de comercialización y su incidencia en los niveles de ventas en la compañía MAX´S Wáter, en el cantón Portoviejo – provincia de Manabí

Marketing strategies have a relevant role within a company, because they consist of structured and planned actions, whose purpose is to achieve the objectives set by the company. The objective of this research article was to analyze the marketing strategies and their impact on sales levels in the company MAX'S Wáter, in the canton of Portoviejo - province of Manabí; According to the diagnosis, deficiencies were found in marketing procedures at almost all levels, its sales income has not grown significantly, since it has had stagnation in recent years, thereby reducing its profitability and business growth.  To do this, information was collected, a research methodology was used that made use of a mixed approach, quantitative-qualitative, based on the use of bibliographic analysis, the review of official documents, the identification of interests and opinions through surveys. aimed at the clients/consumers of their products, whose research results, when tabulated, are essential for taking corrective measures and/or continuous improvement procedures by their managers, which will contribute to the presentation of future proposals with innovative strategies. marketing for institutional strengthening and/or business of the companyLas estrategias de comercialización tienen un rol relevante dentro de una empresa, porque consisten en acciones estructuradas y planificadas, cuyo fin es alcanzar los objetivos trazados por la misma. El objetivo del presente artículo de investigación fue analizar las estrategias de comercialización y su incidencia en los niveles de ventas en la compañía MAX´S Wáter, en el cantón Portoviejo – provincia de Manabí; de acuerdo con el diagnóstico, se hallaron deficiencias en los procedimientos de comercialización casi en todos sus niveles, sus ingresos por ventas no han crecido significativamente, ya que ha tenido un estancamiento durante los últimos años, mermando con ello su rentabilidad y su crecimiento empresarial.  Para ello, se recopiló información, se utilizó una metodología investigativa que hizo uso de un enfoque mixto, de carácter cuantitativo-cualitativo, basado en el empleo del análisis bibliográfico, la revisión de documentos oficiales, la identificación de intereses y opiniones a través de encuestas dirigidas a los clientes/consumidores de sus productos, cuyos resultados de la investigación al ser tabulados, son trascendentales para tomar medidas correctivas y/o procedimientos de mejora continua, por parte de sus directivos, que coadyuvarán a la presentación de futuras propuestas con novedosas estrategias de comercialización  para el fortalecimiento institucional y/o giro de negocio de la empresa

Análisis de indicadores de desempeño financiero de la empresa ecuatoriana de balanceados Coprobalan S. A.

Companies must constantly evaluate their activities to establish strategies that allow their development. The objective of this investigation was to analyze the performance in the Ecuadorian company of balanced Coprobalan S. A.; The methodology used was descriptive, with a quantitative approach. Indicators of liquidity, solvency, management and profitability were applied in accordance with policies and public information exposed by the Superintendency of Companies, Securities and Insurance of Ecuador. As a result, it was evidenced that the company of balanced products Coprobalan S.A. complies with its short-term obligations, has a growth projection evidenced in the investments in which it used its own capital and that of third parties, has implemented strategies aimed at improving portfolio rotation, fixed assets and sales, also presenting good management of its expenses, but to achieve greater growth and business development, you must opt for strategies that allow you to increase profitability without compromising relationships with suppliers and the quality of your products.Las empresas deben evaluar constantemente sus actividades para establecer estrategias que permitan su desarrollo.  El objetivo de esta investigación fue analizar el desempeño en la empresa ecuatoriana de balanceados Coprobalan S. A. La metodología empleada fue de carácter descriptivo, con un enfoque cuantitativo. Se aplicó indicadores de liquidez, solvencia, gestión y rentabilidad de acuerdo con políticas e información pública expuesta por la Superintendencia de Compañías, Valores y Seguros del Ecuador. Como resultado se evidenció que la empresa de productos balanceados Coprobalan S.A. cumple con sus obligaciones a corto plazo, tiene proyección de crecimiento evidenciado en las inversiones en las cuales utilizó capital propio y de terceros, ha implementado estrategias orientadas a mejorar la rotación de cartera, activo fijo y ventas, presentando además, una buena gestión de sus gastos, pero para lograr un mayor crecimiento y desarrollo empresarial debe optar por estrategias que permitan aumentar la rentabilidad sin comprometer las relaciones con los proveedores y la calidad de sus productos

Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans

Genome-wide association studies (GWAS) have identified numerous common prostate cancer (PrCa) susceptibility loci. We have fine-mapped 64 GWAS regions known at the conclusion of the iCOGS study using large-scale genotyping and imputation in 25 723 PrCa cases and 26 274 controls of European ancestry. We detected evidence for multiple independent signals at 16 regions, 12 of which contained additional newly identified significant associations. A single signal comprising a spectrum of correlated variation was observed at 39 regions; 35 of which are now described by a novel more significantly associated lead SNP, while the originally reported variant remained as the lead SNP only in 4 regions. We also confirmed two association signals in Europeans that had been previously reported only in East-Asian GWAS. Based on statistical evidence and linkage disequilibrium (LD) structure, we have curated and narrowed down the list of the most likely candidate causal variants for each region. Functional annotation using data from ENCODE filtered for PrCa cell lines and eQTL analysis demonstrated significant enrichment for overlap with bio-features within this set. By incorporating the novel risk variants identified here alongside the refined data for existing association signals, we estimate that these loci now explain ∼38.9% of the familial relative risk of PrCa, an 8.9% improvement over the previously reported GWAS tag SNPs. This suggests that a significant fraction of the heritability of PrCa may have been hidden during the discovery phase of GWAS, in particular due to the presence of multiple independent signals within the same regio

Global disparities in surgeons’ workloads, academic engagement and rest periods: the on-calL shIft fOr geNEral SurgeonS (LIONESS) study

: The workload of general surgeons is multifaceted, encompassing not only surgical procedures but also a myriad of other responsibilities. From April to May 2023, we conducted a CHERRIES-compliant internet-based survey analyzing clinical practice, academic engagement, and post-on-call rest. The questionnaire featured six sections with 35 questions. Statistical analysis used Chi-square tests, ANOVA, and logistic regression (SPSS® v. 28). The survey received a total of 1.046 responses (65.4%). Over 78.0% of responders came from Europe, 65.1% came from a general surgery unit; 92.8% of European and 87.5% of North American respondents were involved in research, compared to 71.7% in Africa. Europe led in publishing research studies (6.6 ± 8.6 yearly). Teaching involvement was high in North America (100%) and Africa (91.7%). Surgeons reported an average of 6.7 ± 4.9 on-call shifts per month, with European and North American surgeons experiencing 6.5 ± 4.9 and 7.8 ± 4.1 on-calls monthly, respectively. African surgeons had the highest on-call frequency (8.7 ± 6.1). Post-on-call, only 35.1% of respondents received a day off. Europeans were most likely (40%) to have a day off, while African surgeons were least likely (6.7%). On the adjusted multivariable analysis HDI (Human Development Index) (aOR 1.993) hospital capacity > 400 beds (aOR 2.423), working in a specialty surgery unit (aOR 2.087), and making the on-call in-house (aOR 5.446), significantly predicted the likelihood of having a day off after an on-call shift. Our study revealed critical insights into the disparities in workload, access to research, and professional opportunities for surgeons across different continents, underscored by the HDI

Media and the Coverage of Psychiatry

Background and aim: Psychiatric issues have often been a focus for the media. Studies have differed in their findings about how the subject matter is portrayed in newspapers.We compared tone and content of Irish print with the British, broadsheets and tabloids, and the coverage of physical and mental illness. Methods: A selection of Irish and British broadsheet and tabloid newspapers were examined page by page by researchers for period of 6 months. Various parameters investigated including who the authors were, commenting on the tone, focus and topic of the articles. A comparison of the parameters between the two countries was made. Results: The total numbers of newspapers studied in six months were 579. In comparison the tone of heading and article was neutral for both Irish and English articles. The tone was more negative (and sensationlist) on tabloids compared to dailies and Sunday newpapers. Predominantly for articles related to mental and physical illnesses tone of headline and article itself was neutral in daily and Sunday broadsheets and dramatic in daily tabloids. Conclusions: To ensure accuracy of information and a more balanced article, we feel more articles should be written by health care professionals themselves, especially for tabloids. Databases now exist where journalists can contact the health care professionals for various illnesses

Peer reviewing made easy

Peer review in scientific journals has existed for over 200 years. This process is currently the accepted way of assessing scientific manuscripts prior to publication for most journals. Despite this, little has been written about the process of peer reviewing, with hardly anything specific to psychiatric journals. This article answers fundamental questions related to peer reviewing and includes practical tips to writing reviews. It will be helpful for those keen on improving their knowledge about the peer-review process. It will not only benefit those who are reviewers or thinking about becoming reviewers, but also authors, who can use the information to improve their chances of publication.