Impact des gisements des phosphates sur la radioactivité dans les échantillons d’eau naturelle et d’air au Marocag

Impact of the phosphate layers on the radioactivity in the natural water samples and air in MoroccoIn this work, we present the results of radioactivity measurements in some samples of phosphate deposits and in samples in interaction with these  phosphate deposits such air and water. In phosphate samples, we have determined with gamma spectrometry using a well NaI(Tl) detector, concentrations of uranium in some samples of unrefined Moroccan phosphates. In air, we have measured, with nuclear solid track detector LR 115 type II,the volumic activity of 222Rn in some dwellings situated in phosphate areas. In water, we have measured activities of uranium and radium radio-isotopes (234U, 238U) with alpha spectrometry and those of radium ( 226Ra, 228Ra) with gamma spectrometry using a 220 cm3 low-background well type gamma ray detector in the aboratoire Souterrain de Modane (LSM-Centre National de la Recherche Scientifique (CNRS/CEA, France).The obtained results in Moroccan  phosphate samples and in samples in interaction with them are comparable to those habitually obtained in the same samples in the world and these activity do not present any risk for public health. Some harmful effects in the longterm could be avoided by simple precautions such ventilation of dwellings and localities of mining treatment

Comparaison des activités des isotopes de l'uranium et du radium dans quelques échantillons d'eau de puits et de sources thermales au Maroc

Les activités des isotopes de l'uranium et du radium (234U,238U,226Ra,228Ra) ainsi que les rapports d'activité (234U/238U,226Ra/238U,228 Ra/226Ra) ont été mesurés, pour la première fois au Maroc, dans 15 échantillons d'eau de puits et 12 échantillons d'eau de sources thermales. Les résultats obtenus montrent que, contrairement aux eaux de puits, les eaux des sources thermales présentent des activités de238U relativement faibles et des activités de226Ra et des rapports234U/238U élevés. Les activités de l'uranium et du radium mesurées sont comparables à celles que l'on trouve habituellement dans d'autres régions non polluées du monde, elles sont inférieures aux limites maximales admissibles ce qui ne pose aucun risque pour la santé publique au Maroc.Activities and activity ratios of uranium and radium isotopes (234U,238U,226Ra,228Ra,234U/238U,226Ra/238U,228Ra/226Ra) have been determined, for the first time in Morocco, for 15 well water samples and 12 spring water samples. The obtained results show that, unlike well waters, the thermal spring waters present relatively low 238U activities and elevated226Ra activities and 234U/238U activity ratios. Uranium and radium activities are similar to those published for other non polluting regions of the world, they are inferior to the Maximum Contaminant Levels and don't present any risk for public health in Morocco

Datation des carbonates impurs au Maroc à l’aide de la méthode de déséquilibre radioactif 230Th/234U

Au cours de ce travail, nous avons entrepris une série de mesures uranium, thorium sur des carbonates impurs en utilisant la méthode de dissolution totale (TSD). La correction des âges des dépôts, témoin d’une/des phase(s) humide(s) durant laquelle (lesquelles) la précipitation des carbonates a eu lieu, a été effectuée au moyen des techniques isochrones. Les résultats isotopiques obtenus montrent que: (1) le Plateau Central Marocain a connu au moins, deux phases humides, la première antérieure à 350 ka et la dernière récente au cours de l'épisode climatique Holocène, (2) la région d'Abda Doukalla a connu plusieurs épisodes de précipitations des carbonates qui datent respectivement de >350 ka, 229 ka, 140 ka, 98 ka, 42 ka et 20 ka.Mots-clés : dépôts quaternaires, déséquilibres radioactifs, spectrométrie alpha, carbonates impurs, travertin, plateau central marocain, Abda-Doukkala

Impact of Tube Voltage on Radiation Dose (CTDI) and Image Quality at Chest CT Examination

During Computed Tomography (CT) scan examinations, it is important to ensure a good diagnosis by providing the maximum information to detect pathologies and this can be done with a reduced dose. In this respect, several methods of dose reduction have been studied and evaluated. This work investigates the effect of tube voltage while varying the tube current on image quality and radiation dose at Chest CT examination. This study was conducted on HITACHI CT 16 slice Scanner using two phantoms for evaluating the dose and image quality; a PMMA phantom and a CATPHAN 500. Two tube voltages of 120 KVp and 100 KVp have been used for some variation of the tube currents (mAs) and recording the values of the measured quantities (CTDIv, spatial resolution, contrast to noise ratio CNR and noise). The scanning with 100 KVp at Chest CT examination led to a reduction in CTDIv until 45 %, an increase of noise from 17 % to 45 %, and the Spatial Resolution fell slightly (6 and 7 pl/cm) compared to the 120 KVp. The CNR shows a slight regression from 11 to 22 % for the 120 KVp and 100 KVp. This study has shown that despite the increase in the image noise at low tube voltage 100 KVp, it is possible to reduce the radiation dose by up to 45 % without degradation of image quality at Chest CT examination. Further works will evaluate the effect of acquisition parameters in other CT examinations

Gas Monetisation Intricacies: Evidence from Indonesia

Indonesia's geographical spread as an archipelago results in a unique and sophisticated electricity distribution. Consequently, PLN, Indonesia's state-owned electricity company, faces several challenges in implementing a robust gas monetisation scheme given these peculiar features of Indonesia's electricity sector. We identify and evaluate the risks and critical issues regarding Indonesia's gas monetisation policy formulation and implementation, particularly the changing regulation and reforms of the past three decades. We surmise that a sound energy policy of gas investment and utilisation by PLN and other energy stakeholders is fundamental. This will manifest in sound business strategies, especially in addressing contractual difficulties and infrastructural deficiencies in securing long-term gas supplies for gas power plants. Some positive approaches are already being adopted by the Indonesian electricity sector stakeholders to tackle the challenges in gas transportation like small scale LNG, marine LNG and CNG but these efforts need to be consistently pursued over the planning horizon. Keywords: gas monetisation; long-term gas supplies; gas transportation JEL Classifications: L95, N7, Q

Blood transcriptional biomarkers of acute viral infection for detection of pre-symptomatic SARS-CoV-2 infection: a nested, case-control diagnostic accuracy study

Background We hypothesised that host-response biomarkers of viral infections might contribute to early identification of individuals infected with SARS-CoV-2, which is critical to breaking the chains of transmission. We aimed to evaluate the diagnostic accuracy of existing candidate whole-blood transcriptomic signatures for viral infection to predict positivity of nasopharyngeal SARS-CoV-2 PCR testing.Methods We did a nested case-control diagnostic accuracy study among a prospective cohort of health-care workers (aged ≥18 years) at St Bartholomew’s Hospital (London, UK) undergoing weekly blood and nasopharyngeal swab sampling for whole-blood RNA sequencing and SARS-CoV-2 PCR testing, when fit to attend work. We identified candidate blood transcriptomic signatures for viral infection through a systematic literature search. We searched MEDLINE for articles published between database inception and Oct 12, 2020, using comprehensive MeSH and keyword terms for “viral infection”, “transcriptome”, “biomarker”, and “blood”. We reconstructed signature scores in blood RNA sequencing data and evaluated their diagnostic accuracy for contemporaneous SARS-CoV-2 infection, compared with the gold standard of SARS-CoV-2 PCR testing, by quantifying the area under the receiver operating characteristic curve (AUROC), sensitivities, and specificities at a standardised Z score of at least 2 based on the distribution of signature scores in test-negative controls. We used pairwise DeLong tests compared with the most discriminating signature to identify the subset of best performing biomarkers. We evaluated associations between signature expression, viral load (using PCR cycle thresholds), and symptom status visually and using Spearman rank correlation. The primary outcome was the AUROC for discriminating between samples from participants who tested negative throughout the study (test-negative controls) and samples from participants with PCR-confirmed SARS-CoV-2 infection (test-positive participants) during their first week of PCR positivity.Findings We identified 20 candidate blood transcriptomic signatures of viral infection from 18 studies and evaluated their accuracy among 169 blood RNA samples from 96 participants over 24 weeks. Participants were recruited between March 23 and March 31, 2020. 114 samples were from 41 participants with SARS-CoV-2 infection, and 55 samples were from 55 test-negative controls. The median age of participants was 36 years (IQR 27–47) and 69 (72%) of 96 were women. Signatures had little overlap of component genes, but were mostly correlated as components of type I interferon responses. A single blood transcript for IFI27 provided the highest accuracy for discriminating between test-negative controls and test-positive individuals at the time of their first positive SARS-CoV-2 PCR result, with AUROC of 0·95 (95% CI 0·91–0·99), sensitivity 0·84 (0·70–0·93), and specificity 0·95 (0·85–0·98) at a predefined threshold (Z score >2). The transcript performed equally well in individuals with and without symptoms. Three other candidate signatures (including two to 48 transcripts) had statistically equivalent discrimination to IFI27 (AUROCs 0·91–0·95).Interpretation Our findings support further urgent evaluation and development of blood IFI27 transcripts as a biomarker for early phase SARS-CoV-2 infection for screening individuals at high risk of infection, such as contacts of index cases, to facilitate early case isolation and early use of antiviral treatments as they emerge

Immune boosting by B.1.1.529 (Omicron) depends on previous SARS-CoV-2 exposure

The Omicron, or Pango lineage B.1.1.529, variant of SARS-CoV-2 carries multiple spike mutations with high transmissibility and partial neutralizing antibody (nAb) escape. Vaccinated individuals show protection from severe disease, often attributed to primed cellular immunity. We investigated T and B cell immunity against B.1.1.529 in triple mRNA vaccinated healthcare workers (HCW) with different SARS-CoV-2 infection histories. B and T cell immunity against previous variants of concern was enhanced in triple vaccinated individuals, but magnitude of T and B cell responses against B.1.1.529 spike protein was reduced. Immune imprinting by infection with the earlier B.1.1.7 (Alpha) variant resulted in less durable binding antibody against B.1.1.529. Previously infection-naïve HCW who became infected during the B.1.1.529 wave showed enhanced immunity against earlier variants, but reduced nAb potency and T cell responses against B.1.1.529 itself. Previous Wuhan Hu-1 infection abrogated T cell recognition and any enhanced cross-reactive neutralizing immunity on infection with B.1.1.529

Quantitative, multiplexed, targeted proteomics for ascertaining variant specific SARS-CoV-2 antibody response

Determining the protection an individual has to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants of concern (VoCs) is crucial for future immune surveillance, vaccine development, and understanding of the changing immune response. We devised an informative assay to current ELISA-based serology using multiplexed, baited, targeted proteomics for direct detection of multiple proteins in the SARS-CoV-2 anti-spike antibody immunocomplex. Serum from individuals collected after infection or first- and second-dose vaccination demonstrates this approach and shows concordance with existing serology and neutralization. Our assays show altered responses of both immunoglobulins and complement to the Alpha (B.1.1.7), Beta (B.1.351), and Delta (B.1.617.1) VoCs and a reduced response to Omicron (B1.1.1529). We were able to identify individuals who had prior infection, and observed that C1q is closely associated with IgG1 (r > 0.82) and may better reflect neutralization to VoCs. Analyzing additional immunoproteins beyond immunoglobulin (Ig) G, provides important information about our understanding of the response to infection and vaccination

Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19

IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19. Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19. DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022). INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days. MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes. RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively). CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes. TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570