Innovative Family Therapy for Households in Global Complex Humanitarian Crises

The relief societies are diverse and consist of humanitarian organizations and humanitarian NGOs. They provide emergency aid interventions to victims of armed conflicts, protracted wars, famines, and natural disasters across the globe. The relief societies have witnessed multiple arrays of complex humanitarian catastrophes affecting families in varying degrees in a global dimension and impact. These societies have been providing lifesaving assistance and protection for victims of war, orphans, and vulnerable groups. They have been reducing the impact of humanitarian crises on families and communities, providing aid for recovery and improving preparedness for future emergencies for moral, altruistic, and emotional reasons. Crisis-impacted families may be located far from the fragile locale or in the eye of the storm. Their losses may be psychosocial, economic, or psychological distress or mental health issues. At the onset of the Russian–Ukrainian War, families across the global community are already counting their losses. These call for novel therapeutic interventions among clinicians and counseling psychotherapists. This chapter, therefore, highlights existing strategies for innovative therapeutic measures for families affected by complex humanitarian emergencies

A Scoping Analysis of the Psychosocial and Health Implications of COVID-19 Comorbidity-Related Complications in the African States: Recent Developments in Counseling and Therapeutic Options

Since the upsurge of Coronavirus in 2019, the WHO and the US CDC have been detecting and characterizing new variants and providing updates to healthcare workers, the public, and global partners on its spread and effects on patients with noncommunicable diseases and co-morbid ailments. Epidemiology and virologic evidence suggest that COVID-19 and its subsequent deadly variants have been associated with mental and neurological manifestations, including delirium or encephalopathy, agitation, acute cerebrovascular disease, meningoencephalitis, impaired sense of smell or taste, anxiety, depression, and sleep problems. While data on these complications may be available in the global north and south, there is a paucity of literature in most African States. Recent developments in COVID-19-related theories and concepts include ethical principles for clinical, counseling, psycho-therapeutic, and rehabilitation options for special and vulnerable populations, such as pediatric patients, pregnant women, mothers, older people, PLWDs, and other marginalized groups. However, there is no known coordinated and multidisciplinary continuum of clinical, counseling, and psychotherapy COVID-19 care pathways for symptomatic and asymptomatic patients and their families in the African States. Hence, the need for this scoping analysis of existing literature on the psycho-social and health implications of COVID-19 Comorbidity-Related Complications for vulnerable persons in developing societies

(E)-N'-(1-(3-oxo-3H-benzo[f]chromen-2-yl)ethylidene)benzohydrazide protecting rat heart tissues from isoproterenol toxicity: Evidence from in vitro and in vivo tests

International audienceThe current study was aimed to assess the protective effect of a new molecule (E)-N'-(1-(3-oxo-3H-benzo[f]chromen-2-yl)ethylidene)benzohydrazide, denoted 1c, against cardiac remodeling process in isoproterenol (Isop) induced myocardial infarction (MI) in rats. Male Wistar rats were randomly divided into four groups, control, Isop (85 mg/kg body weight was injected subcutaneously into rats at an interval of 24 h for 2 days (6 and 7 day) to induce MI and pretreated animals with acenocoumarol (Ace) (150 μg/kg bw) and 1c (150 μg/kg bw) by oral administration during 7 days and injected with isoproterenol (Isop + Ace) and (Isop + 1c) groups. Results in vitro showed that 1c is endowed with potent inhibition of angiotensin-converting enzyme (ACE) with an IC 39.12 μg/ml. The in vivo exploration evidenced alteration in the ECG pattern, notable cardiac hypertrophy and increase in plasma level of fibrinogen, troponin-T, CK-MB and LDH, AST and ALT by 171%, 300%, 50%, 64% and 75% respectively with histological myocardium necrosis and cells inflammatory infiltration. However, pre-treatment with 1c improved the ECG pattern reduced significantly the cardiac dysfunction markers and ameliorated the thrombolytic process by decreasing fibrinogen level as compared to untreated infracted rats. Overall, (E)-N'-(1-(3-oxo-3H-benzo[f]chromen-2-yl)ethylidene)benzohydrazide 1c could be used as anticoagulant agent to prevent thrombosis in acute myocardial infarction

Oleuropein protects against cerebral ischemia injury in rats : molecular docking, biochemical and histological findings

This study was designed to evaluate the underlying protective mechanisms of oleuropein involved in alleviating brain damage in a rat model of ischemic stroke. Male Wistar rats were divided into four groups; Control, stroke (MCAO), MCAO + clopidogrel (Clop) and MCAO + oleuropein (Ole). Results showed that the MCAO group evidenced significant brain edema (+ 9%) as well as increases of plasma cardiac markers such as lactate deshydrogenase (LDH), creatine kinase (CK-MB), fibrinogen and Trop-T by 11 %, 43%, 168 and 590%, respectively, as compared to the control group. Moreover, infarcted rats exhibited remarkable elevated levels of angiotensin converting enzyme (ACE), both in plasma and brain tissue, with astrocyte swelling and necrotic neurons in the infarct zone, hyponatremia, and increased rate of thiobarbituric acid-reactive substances (TBARS) by 89% associated with decreases in the activity of superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (Cat) by 51%, 44 and 42%, respectively, compared to normal control rats. However, MCAO rats treated with oleuropein underwent mitigation of cerebral edema, correction of hyponatremia, remarkable decrease of plasma fibrinogen and cardiac dysfunctional enzymes, inhibition of ACE activity and improvement of oxidative stress status in brain tissue. Furthermore, in silico analysis showed considerable inhibitions of ACE, protein disulfide isomerase (PDI) and TGF-β1, an indicative of potent anti-embolic properties. Overall, oleuropein offers a neuroprotective effect against ischemic stroke through its antioxidative and antithrombotic activities

Multi-Vortex Tornado Blueprint for Disruptive Global Co-Creation (Inspired by EUvsVirus): Hackathons vs Grand Challenges

Since its burst in early 2020, the Covid-19 pandemic has deeply affected every aspect of daily life, from international trade and travelling to restrictions on an individual level, becoming a complex multi-level and highly multi-faceted problem. Due to its overarching influence and deep impact, it can be seen as one of the most disruptive Grand Challenges of our time. Different from most other lasting Grand Challenges, such as Climate Change, the pandemic exerted its influence with little ramp-up, rapidly transforming health and health systems, human lives, goods and economic flows, decision-making mechanisms, research and innovation, and many other aspects of life in a very short span of time. Grand Challenges require extraordinary efforts from society as a whole since they need holistic, effective, collaborative endeavours to solve them. One such unique orchestrated effort can be observed in the subsequent series of virtual massive EUvsVirus (https://www.euvsvirus.org/ ) events and committed collaborations (‘hackathon’, ‘matchathon’, ‘launchathon’, ‘community’, ‘EIC Covid platform’, and the unparalleled ‘Academia Diffusion Experiment’ [ADE], analysed in chapter “Academia Diffusion Experiment: Trailblazing the Emergence from Co-Creation” of this book). While this chapter explains ‘what’ has been produced with the ADE, inspired by the EUvsVirus phenomenon, the ADE chapter describes ‘how’ it has been done. Both are extremely unique in terms of content, procedure, motivation, collaboration, effects—and they attempt to trailblaze at highest level co-creation, co-evolution, and co-dreaming. Hence, situated as the last chapters of this book. This chapter will shed light on the EUvsVirus events, where over 30,000 individuals from 40 countries came together and addressed the complexity of this massive challenge in a pioneering and groundbreaking way. The chapter is focused on analysing the EUvsVirus hackathon (alongside its mentioned unique spillovers) as a tool, method, and process capable of channelling and activating individuals’ and institutions’ concerns, wills, and commitments into a unique orchestrated open, collaborative response to an urgent Grand Challenge, the pandemic. We are producing a multi-vortex tornado model, resembling the EUvsVirus phenomenon, its components, mechanisms, behaviour and how to replicate it to achieve such disruptive, global organisational effort of co-creation. Especially, the emergence of such collaboration in the face of such urgency leads to the assumption that there are crucial lessons to be learned from this endeavour, quite fittingly encapsulated by these words: ‘We are learning That though we weren't ready for this, We have been readied by it’. Amanda Gorman’s New Year poem (https://amandagormanbooks.com/#the-hill-we-climb-and-other-poems or https://edition.cnn.com/videos/tv/2022/01/06/exp-amanda-gorman-nye-poem.cn

Academia diffusion experiment : trailblazing the emergence from co-creation : open innovation and open collaboration towards ecosystem building

Inspired by EUvsVirus, this chapter focuses on the Academia Diffusion Experiment (ADE) with more than 40 scholars and practitioners around the globe, who transform practice into science through co-creating, co-evolving, and co-dreaming. The chapter first introduces EUvsVirus as the context of the ADE and then uncovers the Denica 2.0 managerial method deployed to facilitate it, its primary constituents, governing principles, participants, information, and risk management. Finally, the chapter reflects the learnings from the ADE by discussing its potentials, problems, and challenges

Academia Diffusion Experiment: Trailblazing the Emergence from Co-Creation : Open Innovation and Open Collaboration Towards Ecosystem Building

Inspired by EUvsVirus, this chapter focuses on the Academia Diffusion Experiment (ADE) with more than 40 scholars and practitioners around the globe, who transform practice into science through co-creating, co-evolving, and co-dreaming. The chapter first introduces EUvsVirus as the context of the ADE and then uncovers the Denica 2.0 managerial method deployed to facilitate it, its primary constituents, governing principles, participants, information, and risk management. Finally, the chapter reflects the learnings from the ADE by discussing its potentials, problems, and challenges

Multi-vortex tornado blueprint for disruptive global co-creation (inspired by EUvsVirus) : hackathons vs grand challenges

Since its burst in early 2020, the Covid-19 pandemic has deeply affected every aspect of daily life, from international trade and travelling to restrictions on an individual level, becoming a complex multi-level and highly multi-faceted problem. Due to its overarching influence and deep impact, it can be seen as one of the most disruptive Grand Challenges of our time. Different from most other lasting Grand Challenges, such as Climate Change, the pandemic exerted its influence with little ramp-up, rapidly transforming health and health systems, human lives, goods and economic flows, decision-making mechanisms, research and innovation, and many other aspects of life in a very short span of time. Grand Challenges require extraordinary efforts from society as a whole since they need holistic, effective, collaborative endeavours to solve them. One such unique orchestrated effort can be observed in the subsequent series of virtual massive EUvsVirus (https://www.euvsvirus.org/) events and committed collaborations (‘hackathon’, ‘matchathon’, ‘launchathon’, ‘community’, ‘EIC Covid platform’, and the unparalleled ‘Academia Diffusion Experiment’ [ADE], analysed in chapter “Academia Diffusion Experiment: Trailblazing the Emergence from Co-Creation” of this book). While this chapter explains ‘what’ has been produced with the ADE, inspired by the EUvsVirus phenomenon, the ADE chapter describes ‘how’ it has been done. Both are extremely unique in terms of content, procedure, motivation, collaboration, effects—and they attempt to trailblaze at highest level co-creation, co-evolution, and co-dreaming. Hence, situated as the last chapters of this book. This chapter will shed light on the EUvsVirus events, where over 30,000 individuals from 40 countries came together and addressed the complexity of this massive challenge in a pioneering and groundbreaking way. The chapter is focused on analysing the EUvsVirus hackathon (alongside its mentioned unique spillovers) as a tool, method, and process capable of channelling and activating individuals’ and institutions’ concerns, wills, and commitments into a unique orchestrated open, collaborative response to an urgent Grand Challenge, the pandemic. We are producing a multi-vortex tornado model, resembling the EUvsVirus phenomenon, its components, mechanisms, behaviour and how to replicate it to achieve such disruptive, global organisational effort of co-creation. Especially, the emergence of such collaboration in the face of such urgency leads to the assumption that there are crucial lessons to be learned from this endeavour, quite fittingly encapsulated by these words: ‘We are learning That though we weren't ready for this, We have been readied by it’. Amanda Gorman’s New Year poem (https://amandagormanbooks.com/#the-hill-we-climb-and-other-poems or https://edition.cnn.com/videos/tv/2022/01/06/exp-amanda-gorman-nye-poem.cnn