The Equivalence of Convergence Results of Modified Mann and Ishikawa Iterations with Errors without Bounded Range Assumption

Let E be an arbitrary uniformly smooth real Banach space, let D be a nonempty closed convex subset of E, and let T:D→D be a uniformly generalized Lipschitz generalized asymptotically Φ-strongly pseudocontractive mapping with q∈F(T)≠∅. Let {an},{bn},{cn},{dn} be four real sequences in [0,1] and satisfy the conditions: (i) an+cn≤1, bn+dn≤1; (ii) an,bn,dn→0 as n→∞ and cn=o(an); (iii) Σn=0∞an=∞. For some x0,z0∈D, let {un},{vn},{wn} be any bounded sequences in D, and let {xn},{zn} be the modified Ishikawa and Mann iterative sequences with errors, respectively. Then the convergence of {xn} is equivalent to that of {zn}

On the Convergence of Multistep Iteration for Uniformly Continuous Φ

It is shown that the convergence of the multistep iterative process with errors is obtained for uniformly continuous Φ-hemicontractive mappings in real Banach spaces. We also revise the problems of C. E. Chidume and C. O. Chidume (2005)

Nitroxoline suppresses metastasis in bladder cancer via EGR1/circNDRG1/miR-520h/smad7/EMT signaling pathway

Bladder cancer is one of the most common and deadly cancer worldwide. Current chemotherapy has shown limited efficacy in improving outcomes for patients. Nitroxoline, an old and widely used oral antibiotic, which was known to treat for urinary tract infection for decades. Recent studies suggested that nitroxoline suppressed the tumor progression and metastasis, especially in bladder cancer. However, the underlying mechanism for anti-tumor activity of nitroxoline remains unclear. Methods: CircRNA microarray was used to explore the nitroxoline-mediated circRNA expression profile of bladder cancer lines. Transwell and wound-healing assay were applied to evaluate the capacity of metastasis. ChIP assay was chosen to prove the binding of promotor and transcription factor. RNA-pulldown assay was performed to explore the sponge of circRNA and microRNA. Results: We first identified the circNDRG1 (has_circ_0085656) as a novel candidate circRNA. Transwell and wound-healing assay demonstrated that circNDRG1 inhibited the metastasis of bladder cancer. ChIP assay showed that circNDRG1 was regulated by the transcription factor EGR1 by binding the promotor of host gene NDRG1. RNA-pulldown assay proved that circNDRG1 sponged miR-520h leading to the overexpression of smad7, which was a negative regulatory protein of EMT. Conclusions: Our research revealed that nitroxoline may suppress metastasis in bladder cancer via EGR1/circNDRG1/miR-520h/smad7/EMT signaling pathway

Applications of 2D-layered palladium diselenide and its van der Waals heterostructures in electronics and optoelectronics

The rapid development of two-dimensional (2D) transition-metal dichalcogenides has been possible owing to their special structures and remarkable properties. In particular, palladium diselenide (PdSe2) with a novel pentagonal structure and unique physical characteristics have recently attracted extensive research interest. Consequently, tremendous research progress has been achieved regarding the physics, chemistry, and electronics of PdSe2. Accordingly, in this review, we recapitulate and summarize the most recent research on PdSe2, including its structure, properties, synthesis, and applications. First, a mechanical exfoliation method to obtain PdSe2 nanosheets is introduced, and large-area synthesis strategies are explained with respect to chemical vapor deposition and metal selenization. Next, the electronic and optoelectronic properties of PdSe2 and related heterostructures, such as field-effect transistors, photodetectors, sensors, and thermoelectric devices, are discussed. Subsequently, the integration of systems into infrared image sensors on the basis of PdSe2 van der Waals heterostructures is explored. Finally, future opportunities are highlighted to serve as a general guide for physicists, chemists, materials scientists, and engineers. Therefore, this comprehensive review may shed light on the research conducted by the 2D material community.Web of Science131art. no. 14

Sustained knock down of PPARγ and bFGF presentation in collagen hydrogels promote MSC osteogenesis

Collagen hydrogels were considered as favourable scaffolding for tissue engineering. It was demonstrated that cytokines and siRNAs could be efficiently retained by collagen hydrogels for controlled release thereby enhancing their bioactivities. Basic fibroblast growth factor (bFGF) was a stimulator for osteogenic differentiation of mesenchymal stem cells (MSC), and PPARγ was a key regulator in MSC osteogenic differentiation. However, whether bFGF and PPARγ could play synergetic roles within a 3D matrix to promote MSC osteogenic differentiation was unknown. In the study, bFGF and PPARγ targeting siRNAs were incorporated into collagen hydrogels for MSC cultivation. Their optimal concentrations in collagen hydrogels were determined. The capacity of bFGF/siRNA-carrying hydrogels in supporting osteogenic differentiation of MSCs was systematically evaluated with multimodality of methods, including flow cytometry, quantitative real-time PCR, Western Blotting, as well as ALP activity and calcium content determination. We demonstrated in 3D collagen hydrogel that both bFGF and siRNA molecules were efficiently retained, strengthening their effects on the incorporated MSCs. Osteogenic analysis demonstrated that the in-situ forming hydrogels carrying bFGF and siRNAs potently promoted osteogenic differentiation of incorporated MSCs, significantly superior to pure collagen and bFGF-carrying collagen. Thus, collagen hydrogels functionalized with bFGF and PPARγ targeting siRNAs may be promising in bone tissue engineering

Fabrication of Adhesive Resistance Surface with Low Wettability on Ti6Al4V Alloys by Electro-Brush Plating

Anti-adhesive Ni coatings with low wettability were successfully fabricated on Ti6Al4V substrates via an electro-brush plating method, and subsequently modified with a fluoroalkylsilane (FAS) film. The surface morphology, chemical compositions, and wettability of the as-prepared coatings were measured using scanning electron microscopy (SEM), X-ray diffractometer (XRD), Fourier transform infrared spectrophotometry (FTIR), and contact angle measurements. The results showed that the surface of Ti6Al4V substrate was endowed with flower-like structures. Each flower-like cluster was constituted by a large number of Ni ions. After surface modification of FAS, the as-prepared Ti6Al4V surface had a water contact angle as high as 151.5°, a sliding angle close to 2.1°, and a solid surface energy as low as 0.97 mJ/m2. Potentiodynamic polarization tests showed that the Ni coating could provide a stable corrosion protection. In addition, the effects of processing conditions, such as working voltage, relative velocity, electrolyte concentration, and processing time, were investigated. The mechanism of the adhesive resistance was proposed, and the low wettability of Ti6Al4V surfaces was explained by Cassie–Baxter model. As a result, it was necessary to reduce the fraction of the solid–liquid interface in order to achieve anti-adhesive surface