The Ursinus Weekly, January 17, 1944

Students hear Senator Ball speak at forum • War loan campaign to be sponsored by Student Council and Weekly: $15,000 goal will permit Ursinus to buy plane • A. J. Cronin\u27s drama Jupiter Laughs marks new undertaking for club • Y handbooks distributed • Churchmen to speak at Y conferences • Hobson girls take amateur night prize • Dr. C. G. Haines addresses students at open meeting • Cabinet room of Y open to faculty members • Y\u27s to stage country fair • Women students see movies about Navy WAVE training • Pastor urges happy spirit in Sunday vespers talk • Daughter born to athlete • Club holds vocabulary bee • Tau Sigs to hold treasure hunt • Physical Education Club hears Tadley • Thespians learn make-up • Russia and Poland • Support bond drive • The judges write • Protect east campus • Wake up and live! • Among our alumni • Girls meet Garnet sextette in first clash of season • Bears drop games to Owls and F. & M. • Wrestlers stop F. & M. streak with hard earned 19-13 win • Marines stopped by Bears, 43-37 • Civilians, Carney pace intra basketball league • Shope leads volleyballhttps://digitalcommons.ursinus.edu/weekly/3107/thumbnail.jp

Decoupled freshwater transport and meridional overturning in the South Atlantic

Freshwater transports (F_ov) by the Atlantic Meridional Overturning Circulation (AMOC) are sensitive to salinity distributions and may determine AMOC stability. However, climate models show large salinity biases, distorting the relation between F_ov and the AMOC. Using free-running models and ocean reanalyses with realistic salinities but quite different AMOCs, we show that the fresh Antarctic Intermediate Water (AAIW) layer eliminates salinity differences across the AMOC branches at ~1200 m, ∆S_1200m, which decouples F_ov from the AMOC south of ~10˚N. As AAIW disappears north of ~10˚N, a large ∆S_1200m allows the AMOC to drive substantial southward F_ov in the North Atlantic. In the South Atlantic the 0-300 m zonal salinity contrasts control the gyre freshwater transports F_gyre, which also determine the total freshwater transports. This decoupling makes the southern F_ov unlikely to play any role in AMOC stability, leaving indirect F_gyre feedbacks or F_ov in the north, as more relevant factors

Assessment of the dimensionality of the Wijma delivery expectancy/experience questionnaire using factor analysis and Rasch analysis

Background: Fear of childbirth has negative consequences for a woman's physical and emotional wellbeing. The most commonly used measurement tool for childbirth fear is the Wijma Delivery Expectancy Questionnaire (WDEQ-A). Although originally conceptualized as unidimensional, subsequent investigations have suggested it is multidimensional. This study aimed to undertake a detailed psychometric assessment of the WDEQ-A; exploring the dimensionality and identifying possible subscales that may have clinical and research utility. Methods: WDEQ-A was administered to a sample of 1410 Australian women in mid-pregnancy. The dimensionality of WDEQ-A was explored using exploratory (EFA) and confirmatory factor analysis (CFA), and Rasch analysis. Results: EFA identified a four factor solution. CFA failed to support the unidimensional structure of the original WDEQ-A, but confirmed the four factor solution identified by EFA. Rasch analysis was used to refine the four subscales (Negative emotions: five items; Lack of positive emotions: five items; Social isolation: four items; Moment of birth: three items). Each WDEQ-A Revised subscale showed good fit to the Rasch model and adequate internal consistency reliability. The correlation between Negative emotions and Lack of positive emotions was strong, however Moment of birth and Social isolation showed much lower intercorrelations, suggesting they should not be added to create a total score. Conclusion: This study supports the findings of other investigations that suggest the WDEQ-A is multidimensional and should not be used in its original form. The WDEQ-A Revised may provide researchers with a more refined, psychometrically sound tool to explore the differential impact of aspects of childbirth fear.Full Tex

Embedding the concept of ecosystems services:The utilisation of ecological knowledge in different policy venues

The concept of ecosystem services is increasingly being promoted by academics and policy makers as a means to protect ecological systems through more informed decision making. A basic premise of this approach is that strengthening the ecological knowledge base will significantly enhance ecosystem health through more sensitive decision making. However, the existing literature on knowledge utilisation, and many previous attempts to improve decision making through better knowledge integration, suggest that producing ‘more knowledge’ is only ever a necessary but insufficient condition for greater policy success. We begin this paper by reviewing what is already known about the relationship between ecological knowledge development and utilisation, before introducing a set of theme issue papers that examine—for the very first time—how this politically and scientifically salient relationship plays out across a number of vital policy venues such as land-use planning, policy-level impact assessment, and cost–benefit analysis. Following a detailed synthesis of the key findings of all the papers, this paper identifies and explores new research and policy challenges in this important and dynamic area of environmental governance

Critical Role of FLRT1 Phosphorylation in the Interdependent Regulation of FLRT1 Function and FGF Receptor Signalling

Background Fibronectin leucine rich transmembrane (FLRT) proteins have dual properties as regulators of cell adhesion and potentiators of fibroblast growth factor (FGF) mediated signalling. The mechanism by which the latter is achieved is still unknown and is the subject of this investigation. Principal Findings Here we show that FLRT1 is a target for tyrosine phosphorylation mediated by FGFR1 and implicate a non-receptor Src family kinase (SFK). We identify the target tyrosine residues in the cytoplasmic domain of FLRT1 and show that these are not direct substrates for Src kinase suggesting that the SFK may exert effects via potentiation of FGFR1 kinase activity. We show that whilst FLRT1 expression results in a ligand-dependent elevation of MAP kinase activity, a mutant version of FLRT1, defective as an FGFR1 kinase substrate (Y3F-FLRT1), has the property of eliciting ligand-independent chronic activation of the MAP kinase pathway which is suppressed by pharmacological inhibition of either FGFR1 or Src kinase. Functional investigation of FGFR1 and FLRT1 signalling in SH-SY5Y neuroblastoma cells reveals that FLRT1 alone acts to induce a multi-polar phenotype whereas the combination of FLRT1 and FGFR activation, or expression of Y3F-FLRT1, acts to induce neurite outgrowth via MAPK activation. Similar results were obtained in a dendrite outgrowth assay in primary hippocampal neurons. We also show that FGFR1, FLRT1 and activated Src are co-localized and this complex is trafficked toward the soma of the cell. The presence of Y3F-FLRT1 rather than FLRT1 resulted in prolonged localization of this complex within the neuritic arbour. Conclusions This study shows that the phosphorylation state of FLRT1, which is itself FGFR1 dependent, may play a critical role in the potentiation of FGFR1 signalling and may also depend on a SFK-dependent phosphorylation mechanism acting via the FGFR. This is consistent with an ‘in vivo’ role for FLRT1 regulation of FGF signalling via SFKs. Furthermore, the phosphorylation-dependent futile cycle mechanism controlling FGFR1 signalling is concurrently crucial for regulation of FLRT1-mediated neurite outgrowth

The Ursinus Weekly, January 22, 1945

Y weekend closes with vespers talk by Dr. A. N. Sayres • Cast of drama is new to Ursinus audience but has experience • Sailors lured to destruction by Lorelei; Ursinus version to have canteen theme • Tickets to be out for Navy ball soon • V-12 men give Johnson transfusions at hospital • Curtain Club lists intra-club groups • Ahoy attends party as pre-meds celebrate • Final intramural contests held by men\u27s, women\u27s debate clubs • Canterbury Club elects Delheim as president; draws up board • Dr. Lentz represents reformed at Cleveland peace conference • Y discussion group is cancelled • Lutherans to organize Thursday • In lab for one day, or why profs get gray • Bears are Madding crowd • Wrestlers drop first meet, 28-10, to Swarthmore • Ursinus narrows margin to six points but falls before Albright team, 65-50 • Twelve girls receive varsity basketball suits as season approacheshttps://digitalcommons.ursinus.edu/weekly/1696/thumbnail.jp