New routes to CSO sustainability: the strategic shift to social enterprise and social investment

The issue of sustainability is becoming more important for civil society, as non-profits, NGOs, and other civil society organisations (CSOs) face a range of political, regulatory, organisational, and financial challenges. This article focuses on the crucial dimension of financial sustainability and the growing awareness of the importance of accessing alternative sources of funds and developing new funding models. These include accessing social investment, using subsidiary businesses to fund programme work, or developing new social enterprises. The article draws on analysis of the funding environment and specific examples to explore the different dimensions of sustainability, and assess why many CSOs are looking to new funding models and alternative routes to sustainability

Dynamics of Race, Culture and Key Indicators of Health in the Nation's 100 Largest Cities and Their Suburbs

Profiles the 2000 status of, and changes since 1990, in rates of health and health-related measures to identify patterns in race/ethnicity, foreign-born status, language use, poverty, income, low birth weight, teen births, prenatal care, and tuberculosis

An imaging gas scintillation proportional counter for the detection of subkiloelectron-volt X-rays

A large area imaging gas scintillation proportional counter (IGSPC) was constructed for use in X-ray astronomy. The IGSPC consists of a gas scintillation proportional counted (GSPC) with a micron polyprotylene window coupled to a multiwire proportional counter (MWPC) via a calcium fluoride window. Over a sensitive area of 21 cu cm the instrument has a measured energy resolution of 17.5% (FWHM) and 1.9 mm (FWHM) spatial resolution at 1.5 keV

Evidence for a Mid-Atomic-Number Atmosphere in the Neutron Star 1E1207.4-5209

Recently Sanwal et al. (2002) reported the first clear detection of absorption features in an isolated neutron star, 1E1207.4-5209. Remarkably their spectral modeling demonstrates that the atmosphere cannot be Hydrogen. They speculated that the neutron star atmosphere is indicative of ionized Helium in an ultra-strong (~1.5x10^{14} G) magnetic field. We have applied our recently developed atomic model (Mori & Hailey 2002) for strongly-magnetized neutron star atmospheres to this problem. We find that this model, along with some simp le atomic physics arguments, severely constrains the possible composition of the atmosphere. In particular we find that the absorption features are naturally associated with He-like Oxygen or Neon in a magnetic field of ~10^{12} G, comparable to the magnetic field derived from the spin parameters of the neutron star. This interpretation is consistent with the relative line strengths and widths and is robust. Our model predicts possible substructure in the spectral features, which has now been reported by XMM-Newton (Mereghetti et al. 2002). However we show the Mereghetti et al. claim that the atmosphere is Iron or some comparable high-Z element at ~ 10^{12} G is easily ruled out by the Chandra and XMM-Newton data.Comment: 5 pages, AASTeX, Revised version. Accepted for publication in ApJ Letter

The role of drug resistance in poor viral suppression in rural South Africa: findings from a population-based study.

BACKGROUND:Understanding factors driving virological failure, including the contribution of HIV drug resistance mutations (DRM), is critical to ensuring HIV treatment remains effective. We examine the contribution of drug resistance mutations for low viral suppression in HIV-positive participants in a population-based sero-prevalence survey in rural South Africa. METHODS:We conducted HIV drug resistance genotyping and ART analyte testing on dried blood spots (DBS) from HIV-positive adults participating in a 2014 survey in North West Province. Among those with virologic failure (> 5000 copies/mL), we describe frequency of DRM to protease inhibitors (PI), nucleoside reverse transcriptase inhibitors (NRTI), and non-nucleoside reverse transcriptase inhibitors (NNRTI), report association of resistance with antiretroviral therapy (ART) status, and assess resistance to first and second line therapy. Analyses are weighted to account for sampling design. RESULTS:Overall 170 DBS samples were assayed for viral load and ART analytes; 78.4% of men and 50.0% of women had evidence of virologic failure and were assessed for drug resistance, with successful sequencing of 76/107 samples. We found ≥1 DRM in 22% of participants; 47% were from samples with detectable analyte (efavirenz, nevirapine or lopinavir). Of those with DRM and detectable analyte, 60% showed high-level resistance and reduced predicted virologic response to ≥1 NRTI/NNRTI typically used in first and second-line regimens. CONCLUSIONS:DRM and predicted reduced susceptibility to first and second-line regimens were common among adults with ART exposure in a rural South African population-based sample. Results underscore the importance of ongoing virologic monitoring, regimen optimization and adherence counseling to optimize durable virologic suppression

A quasioptical steering system for the CCAT/XSPEC submillimeter multi-object spectrometer

A two arm, opto-mechanical positioner mechanism is presented in this proceedings as a candidate steering system for the millimeter-wave XSPEC spectrograph. The design is well matched to the expected target density on the sky, and meeting all requirements of the Cerro Chajnantor Atacama Telescope (CCAT), site environmental conditions (e.g., operating temperature and power dissipation), and the positioning requirements themselves for acquiring and tracking astronomical objects whose light is fed into the XSPEC spectrograph units. The prototype design has been fabricated and tested for basic operations

The Compton hump and variable blue wing in the extreme low-flux NuSTAR observations of 1H0707-495

The Narrow-line Seyfert I galaxy, 1H0707-495, has been well observed in the 0.3-10 keV band, revealing a dramatic drop in flux in the iron K alpha band, a strong soft excess, and short timescale reverberation lags associated with these spectral features. In this paper, we present the first results of a deep 250 ks NuSTAR observation of 1H0707-495, which includes the first sensitive observations above 10 keV. Even though the NuSTAR observations caught the source in an extreme low-flux state, the Compton hump is still significantly detected. NuSTAR, with its high effective area above 7 keV, clearly detects the drop in flux in the iron K alpha band, and by comparing these observations with archival XMM-Newton observations, we find that the energy of this drop increases with increasing flux. We discuss possible explanations for this, the most likely of which is that the drop in flux is the blue wing of the relativistically broadened iron K alpha emission line. When the flux is low, the coronal source height is low, thus enhancing the most gravitationally redshifted emission.Comment: Submitted to MNRAS, comments are welcome. 9 pages, 5 figure