The Effect of Substance P on Ovariectomy-Induced Memory Deficits in Rats

The present experiment was designed to test whether pretreatment with substance P would affect ovariectomy-induced memory deficits in rats for retention in the Morris water maze. Adult female Sprague-Dawley rats were divided to two groups: (1) control (received saline) and (2) experimental group (received substance P). All rats underwent an ovariectomy, as this has been shown to significantly impair spatial reference learning and memory (Monteiro, Matté, Bavaresco, Netto, & Wyse, 2005). Approximately 8 months after surgery, all rats were trained in the Morris water maze in order to evaluate both reference and working memory. Results showed that substance P did not significantly affect performance in any segment of the experiment, when compared with controls. The results of the present experiment do not support the hypothesis that pretreatment with substance P improves spatial and working memory of ovariectomized rats

Land use inventory through merging of LANDSAT (satellite), aerial photography and map sources

There are no author-identified significant results in this report

Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence

Viral immune evasion strategies target key aspects of the host antiviral response. Recently, it has been recognized that Toll-like receptors (TLRs) have a role in innate defense against viruses. Here, we define the function of the vaccinia virus (VV) protein A46R and show it inhibits intracellular signalling by a range of TLRs. TLR signalling is triggered by homotypic interactions between the Toll-like-interleukin-1 resistance (TIR) domains of the receptors and adaptor molecules. A46R contains a TIR domain and is the only viral TIR domain-containing protein identified to date. We demonstrate that A46R targets the host TIR adaptors myeloid differentiation factor 88 (MyD88), MyD88 adaptor-like, TIR domain-containing adaptor inducing IFN-beta (TRIF), and the TRIF-related adaptor molecule and thereby interferes with downstream activation of mitogen-activated protein kinases and nuclear factor kappaB. TRIF mediates activation of interferon (IFN) regulatory factor 3 (IRF3) and induction of IFN-beta by TLR3 and TLR4 and suppresses VV replication in macrophages. Here, A46R disrupted TRIF-induced IRF3 activation and induction of the TRIF-dependent gene regulated on activation, normal T cell expressed and secreted. Furthermore, we show that A46R is functionally distinct from another described VV TLR inhibitor, A52R. Importantly, VV lacking the A46R gene was attenuated in a murine intranasal model, demonstrating the importance of A46R for VV virulence

Unusual behaviours and Impurity Effects in the Noncentrosymmetric Superconductor CePt3Si

We report a study in which the effect of defects/impurities, growth process, off-stoichiometry, and presence of impurity phases on the superconducting properties of noncentrosymmetric CePt3Si is analysed by means of the temperature dependence of the magnetic penetration depth. We found that the linear low-temperature response of the penetration depth -indicative of line nodes in this material- is robust regarding sample quality, in contrast to what is observed in unconventional centrosymmetric superconductors with line nodes. We discuss evidence that the broadness of the superconducting transition may be intrinsic, though not implying the existence of a second superconducting transition. The superconducting transition temperature systematically occurs around 0.75 K in our measurements, in agreement with resistivity and ac magnetic susceptibility data but in conflict with specific heat, thermal conductivity and NMR data in which Tc is about 0.5 K. Random defects do not change the linear low-temperature dependence of the penetration depth in the heavy-fermion CePt3Si with line nodes, as they do in unconventional centrosymmetric superconductors with line nodes.Comment: To appear in New Journal of Physic

Synthesis and characterisation of ruthenium complexes containing a pendent catechol ring

A series of [Ru(bipy)₂L]⁺ and [Ru(phen)₂L]⁺ complexes where L is 2-[5-(3,4-dimethoxyphenyl)-4H-1,2,4-triazol-3-yl]pyridine (HL1) and 4-(5-pyridin-2-yl-4H-1,2,4-triazol-3-yl)benzene-1,2-diol (HL2) are reported. The compounds obtained have been characterised using X-ray crystallography, NMR, UV/Vis and emission spectroscopies. Partial deuteriation is used to determine the nature of the emitting state and to simplify the NMR spectra. The acid-base properties of the compounds are also investigated. The electronic structures of [Ru(bipy)₂L1]⁺ and Ru(bipy)₂HL1]²⁺ are examined using ZINDO. Electro and spectroelectrochemical studies on [Ru(bipy)₂(L2)]⁺ suggest that proton transfer between the catechol and triazole moieties on L2 takes place upon oxidation of the L2 ligand

Remark on Pauli-Villars Lagrangian on the Lattice

It is interesting to superimpose the Pauli-Villars regularization on the lattice regularization. We illustrate how this scheme works by evaluating the axial anomaly in a simple lattice fermion model, the Pauli-Villars Lagrangian with a gauge non-invariant Wilson term. The gauge non-invariance of the axial anomaly, caused by the Wilson term, is remedied by a compensation among Pauli-Villars regulators in the continuum limit. A subtlety in Frolov-Slavnov's scheme for an odd number of chiral fermions in an anomaly free complex gauge representation, which requires an infinite number of regulators, is briefly mentioned.Comment: 14 pages, Phyzzx. The final version to appear in Phys. Rev.

Extremely Large and Anisotropic Upper Critical Field and the Ferromagnetic Instability in UCoGe

Magnetoresistivity measurements with fine tuning of the field direction on high quality single crystals of the ferromagnetic superconductor UCoGe show anomalous anisotropy of the upper critical field H_c2. H_c2 for H // b-axis (H_c2^b) in the orthorhombic crystal structure is strongly enhanced with decreasing temperature with an S-shape and reaches nearly 20 T at 0 K. The temperature dependence of H_c2^a shows upward curvature with a low temperature value exceeding 30 T, while H_c2^c at 0 K is very small (~ 0.6 T). Contrary to conventional ferromagnets, the decrease of the Curie temperature with increasing field for H // b-axis marked by an enhancement of the effective mass of the conduction electrons appears to be the origin of the S-shaped H_c2^b curve. These results indicate that the field-induced ferromagnetic instability or magnetic quantum criticality reinforces superconductivity.Comment: 5 pages, 4 figures, accepted for publication in J. Phys. Soc. Jp