Effect of Long-Term Physical Exercise on Blood Pressure in African Americans

International Journal of Exercise Science 7(3) : 186-193, 2014. Long-term physical exercise has been shown to noticeably reduce blood pressure (BP) and remarkably attenuate symptoms of hypertension. It is believed that physical exercise induces these beneficial effects by increasing the blood supply to the brain, enhancing the release of growth factors from skeletal muscles into the bloodstream, facilitating neurogenesis, stimulating angiogenesis, and influencing endothelial cell proliferation and subsequent endothelial cell membrane permeability. Previous findings also revealed that physical exercise significantly elevates brain-derived neurotrophic factor (BDNF) concentrations which appear to increase dramatically in BP-sensing neurons during hypertension. Elevating BDNF levels is the proposed mechanism by which physical exercise reduces BP and lowers hypertension risk. Relatively effective measures exist today to prevent or delay much of the burden of hypertension and curtail or remediate the devastating consequences of chronic elevated BP over time. Nevertheless, this medical problem contributes to excess risk for morbidity and mortality and is a major public health concern, especially among minority populations. To date, however, it appears as though few studies have focused on the impact of non-pharmacological, behavioral interventions such as physical exercise on BP in minorities. Therefore, the purpose of the present study was to examine the effect of long-term exercise on BP in an African American sample. Specifically, the aim was to determine whether a 12-week moderate intensity physical exercise program would significantly decrease BP. Because data provided evidence to support the hypothesis tested, it was concluded that physical exercise resulted in a significant reduction in BP in the African Americans sampled

The influence of shade and organic fertilizer treatments on the physiology and establishment of Theobroma cacao clones

Aims: This experiment aimed to determine whether the soil application of organic fertilizers can help the establishment of cacao and whether shade alters its response to fertilizers. Study Design: The 1.6 ha experiment was conducted over a period of one crop year (between April 2007 and March 2008) at the Cocoa Research Institute of Ghana. It involved four cacao genotypes (T 79/501, PA 150, P 30 [POS] and SCA 6), three shade levels (‘light’, ‘medium’ and ‘heavy’) and two fertilizer treatments (‘no fertilizer’, and ‘140 kg/ha of cacao pod husk ash (CPHA) plus poultry manure at 1,800 kg/ha). The experiment was designed as a split-plot with the cacao genotypes as the main plot factor and shade x fertilizer combinations as the sub-plots. Methodology: Gliricidia sepium and plantains (Musa sapientum) were planted in different arrangements to create the three temporary shade regimes for the cacao. Data were collected on temperature and relative humidity of the shade environments, initial soil nutrients, soil moisture, leaf N, P and K+ contents, survival, photo synthesis and growth of test plants. Results: The genotypes P 30 [POS] and SCA 6 showed lower stomatal conductance under non-limiting conditions. In the rainy seasons, plants under light shade had the highest CO2 assimilation rates. However, in the dry season, plants under increased shade recorded greater photosynthetic rates (P = .03). A significant shade x fertilizer interaction (P = .001) on photosynthesis in the dry season showed that heavier shade increases the benefits that young cacao gets from fertilizer application in that season. Conversely, shade should be reduced during the wet seasons to minimize light limitation to assimilation. Conclusion: Under ideal weather conditions young cacao exhibits genetic variability on stomatal conductance. Also, to optimize plant response to fertilizer application shade must be adjusted taking the prevailing weather condition into account

Maximum tumor diameter is associated with event-free survival in PET-negative patients with stage I/IIA Hodgkin lymphoma.

Introduction: the high cure rates achieved in early-stage (ES) Hodgkin lymphoma (HL) are one of the great successes of hemato-oncology, but late treatment-related toxicity undermines long-term survival. Improving overall survival and quality of life further will require maintaining disease control while potentially de-escalating chemotherapy and/or omitting radiotherapy to reduce late toxicity. Accurate stratification of patients is required to facilitate individualized treatment approaches. Response assessment using 18F-fluorodeoxyglucose positron emission tomography (PET) is a powerful predictor of outcome in HL,1,2 and has been used in multiple studies, including the United Kingdom National Cancer Research Institute Randomised Phase III Trial to Determine the Role of FDG–PET Imaging in Clinical Stages IA/IIA Hodgkin’s Disease (UK NCRI RAPID) trial, to investigate whether patients achieving complete metabolic remission (CMR) can be treated with chemotherapy alone.3-5 These PET-adapted trials have demonstrated that omitting radiotherapy results in higher relapse rates, but without compromising overall survival.3-5 For the 75% of patients who achieved CMR in RAPID, neither baseline clinical risk stratification (favorable/unfavorable) nor PET (Deauville score 1/2) predicted disease relapse; additional biomarkers are needed.1 Tumor bulk has long been recognized as prognostic in HL,1,6 but there remains uncertainty about the significance and definition of bulk in the era of PET-adapted treatment.7 We performed a subsidiary analysis of RAPID to assess the prognostic value of baseline maximum tumor dimension (MTD) in patients achieving CMR. Methods: ee have previously reported the RAPID trial design, primary results, and outcomes according to pretreatment risk stratification and PET score.1,3 Patients were aged 16 to 75 years with untreated ES-HL and without B-symptoms or mediastinal bulk (mass > 1/3 internal mediastinal diameter at T5/6).6 Metabolic response after 3 cycles of ABVD chemotherapy (doxorubicin, bleomycin, vinblastine, and dacarbazine) was centrally assessed using PET (N = 562). Patients with CMR (ie, Deauville score 1-2) were randomly assigned to receive involved field radiotherapy (IFRT; n = 208) or no further therapy (NFT; n = 211). PET-positive patients (score, 3-5; n = 143) received a fourth cycle of ABVD and IFRT. Baseline disease assessment was performed by computed tomography, and bidimensional target lesion measurements were reported by local radiologists in millimeters. The association of baseline MTD with HL-related event-free survival (EFS: progression or HL-related death) and progression-free survival (PFS) (progression or any-cause death) was assessed using Kaplan-Meier and Cox regression analyses. Non-HL deaths were either related to primary treatment toxicity or occurred in HL remission.1 United Kingdom ethical approval for the RAPID trial was via the UK Multicentre Research ethics committee. Results and discussion: baseline patient characteristics have been previously described.1 Median age was 34 years (range, 16-75 years); 184 (37.4%) of 492 patients had unfavorable risk by European Organisation for Research and Treatment of Cancer criteria, and 155 (32.3%) of 480 by German Hodgkin Study Groupcriteria. Median MTD for patients achieving CMR was 3.0 cm (interquartile range, 2.0-4.0 cm) and 3.0 cm (interquartile range, 1.8-4.5 cm) in the NFT and IFRT groups, respectively, whereas PET-positive patients had a median MTD of 3.9 cm (interquartile range, 2.8-5.1 cm). After a median follow-up of 61.6 m, 44 HL progression events occurred: 21 NFT, 9 IFRT and 14 PET-positive. No patient received salvage treatment without documented progression. Only 5 HL-related deaths occurred (1 IFRT, 4 PET-positive), and 12 non-HL deaths (4 NFT, 6 IFRT, 2 PET-positive).1 For patients with CMR (N = 419), there was a strong association between MTD and EFS (hazard ratio [HR], 1.19; 95% confidence interval [CI], 1.02-1.39; P = .02), adjusting for treatment group, with an approximate 19% increase in HL risk per centimeter increase in MTD. The association was similar in both treatment groups (NFT HR, 1.20 [95% CI, 0.99-1.44; P = .06]; IFRT HR, 1.19 [95% CI, 0.92-1.55; P = .19]). The observed effect sizes did not markedly change after adjusting for baseline clinical risk factors, and similar results were observed for PFS (supplemental Table 1). In contrast, for PET-positive patients, there was no association between MTD and EFS (HR, 0.88; 95% CI, 0.70-1.11; P = .29) or PFS (HR, 0.87; 95% CI, 0.70-1.08; P = .21). In an exploratory analysis within the NFT group, MTD was dichotomized using increasing 1-cm intervals to investigate the relationship between MTD thresholds and EFS. The largest effect size was observed with an MTD threshold of ≥5 cm (Table 1). Similar results were observed for PFS; this threshold also performed best in time-dependent receiver operating characteristic curve analyses. It was not possible to assess MTD thresholds in the IFRT group with only 9 events. Among all randomized patients, 79 (18.9%) had MTD of ≥5 cm, the majority with mediastinal (n = 43), supraclavicular (n = 17), or cervical (n = 16) locations. Five-year EFS for patients with MTD of ≥5 cm randomly assigned to NFT and IFRT was 79.3% (n = 39; 95% CI, 66.6%-92.0%) and 94.9% (n = 40; 95% CI, 88.0%-100%), respectively (P = .03; Figure 1)

Positron Emission Tomography Score Has Greater Prognostic Significance Than Pretreatment Risk Stratification in Early-Stage Hodgkin Lymphoma in the UK RAPID Study.

PURPOSE: Accurate stratification of patients is an important goal in Hodgkin lymphoma (HL), but the role of pretreatment clinical risk stratification in the context of positron emission tomography (PET) -adapted treatment is unclear. We performed a subsidiary analysis of the RAPID trial to assess the prognostic value of pretreatment risk factors and PET score in determining outcomes. PATIENTS AND METHODS: Patients with stage IA to IIA HL and no mediastinal bulk underwent PET assessment after three cycles of doxorubicin, bleomycin, vinblastine, and dacarbazine; 143 PET-positive patients (PET score, 3 to 5) received a fourth doxorubicin, bleomycin, vinblastine, and dacarbazine cycle and involved-field radiotherapy, and 419 patients in complete metabolic remission were randomly assigned to receive involved-field radiotherapy (n = 208) or no additional treatment (n = 211). Cox regression was used to investigate the association between PET score and pretreatment risk factors with HL-specific event-free survival (EFS). RESULTS: High PET score was associated with inferior EFS, before (P .4). CONCLUSION: In RAPID, a positive PET scan did not carry uniform prognostic weight; only a PET score of 5 was associated with inferior outcomes. This suggests that in future trials involving patients without B symptoms or mediastinal bulk, a score of 5 rather than a positive PET result should be used to guide treatment escalation in early-stage HL

Functional green roofs: Importance of plant choice in maximising summertime environmental cooling and substrate insulation potential

Green roof plants can reduce local air temperatures and heat load to a building in the summer, improving thermal comfort of residents. Little is known, however, about how different plants compare in their potential to provide these two ecosystem services. Consequently, this study investigated whether some plants can offer more potential summertime environmental cooling and substrate insulation than others. Over two summers (2012/2013), canopies of two succulent and four broad-leaved plant genotypes, with contrasting plant traits, were monitored alongside bare substrate in Reading, UK. Plants were studied outdoors within small plots (1.5 × 1.5 × 0.1 m). Continuous monitoring took place during warm days and nights and included variables (leaf surface temperatures) and fluxes (long-wave radiation, sensible heat flux and transpiration) that are indicative of cooling potential. The strength of substrate insulation was estimated by comparing the ground heat flux below the canopies to that of the bare substrate. Plant traits (leaf colour or thickness), structural parameters (height and leaf area index, LAI), radiative properties (albedo and emissivity), and stomatal conductance were also measured to help explain the differences in cooling potential among the species. Non-succulent canopies, in particular light-coloured ones, with high leaf stomatal conductance and high LAI provided maximum potential for substrate insulation and environmental cooling in hot periods, particularly compared to bare substrate and thick-leaved succulents. These results suggest that succulent plants are not best suited to provide significant summertime environmental cooling and substrate insulation and that others (e.g. Salvia and Stachys) might be preferable where the delivery of these benefits is a priority. Our findings highlight that, in addition to survival, aesthetics and cost, the plants’ ability to deliver a range of ecosystem services should be considered in the plant selection/green roof planning process

Dynamics of Coupling Functions in Globally Coupled Maps: Size, Periodicity and Stability of Clusters

It is shown how different globally coupled map systems can be analyzed under a common framework by focusing on the dynamics of their respective global coupling functions. We investigate how the functional form of the coupling determines the formation of clusters in a globally coupled map system and the resulting periodicity of the global interaction. The allowed distributions of elements among periodic clusters is also found to depend on the functional form of the coupling. Through the analogy between globally coupled maps and a single driven map, the clustering behavior of the former systems can be characterized. By using this analogy, the dynamics of periodic clusters in systems displaying a constant global coupling are predicted; and for a particular family of coupling functions, it is shown that the stability condition of these clustered states can straightforwardly be derived.Comment: 12 pp, 5 figs, to appear in PR

Swift heavy ion irradiation of GaSb: from ion tracks to nano-porous networks

Ion track formation, amorphisation, and the formation of porosity in crystalline GaSb induced by 185 MeV $^{197}$Au swift heavy ion irradiation is investigated as a function of fluence and irradiation angle relative to the surface normal. RBS/C and SAXS reveal an ion track radius between 3 nm and 5 nm. The observed pore morphology and saturation swelling of GaSb films shows a strong irradiation angle dependence. Raman spectroscopy and scanning electron microscopy show that the ion tracks act as a source of strain in the material leading to macroscopic plastic flow at high fluences and off normal irradiation. The results are consistent with the ion hammering model for glasses. Furthermore, wide angle X-ray scattering reveals the formation of nano crystallites inside otherwise amorphous GaSb after the onset of porosity

Effects of Adding Sodium and Fluoride Ions to Glass Ionomer on its Interactions with Sodium Fluoride Solution

This investigates the effects of the addition of Na and F ions to a glass ionomer cement in which those ions are not inherently present on its interactions with dilute (0.2%) NaF solution. Both the effect of the solution on the cement\u27s surface morphology and the effect of the cement on the solution in terms of take up of Na+ and F- and of change in pH are to be investigated. These results are to be compared to previous results obtained with glasses which contained both, one, or neither of the ions as components of their glasses. NaF (1.3% by weight in the mixed cement) was added to the powder components of a glass ionomer based on LG30 glass (which contains Al, Si, Ca, P, and O only). Discs of cement were set in moulds at 37°C for 1h then stored in water at 37°C for 3 days. Each test disc was then immersed in 10ml 0.2% NaF solution whereas controls remained immersed in water (N=3 for test and control). Test and control disc surfaces were assessed both qualitatively by electron microscopy and quantitatively by linear profilometry (R(a) values). Potentiometry was used to measure solution pH and Na and F concentrations using a pH electrode and suitable ion selective electrodes both before and after cement immersion. The surface of test specimens was subject considerable disruption with the polysalt cement matrix being removed and residual glass particles being disclosed. The controls showed no such disruption. This effect was reflected in a significant difference of R(a). Such an effect was not shown by test and control surfaces of LG30 but a similar effect was to that shown by LG26 (which contains F as a glass component). Solution pH changed by 1 unit which was much more than the change shown by LG30 or LG26 but is similar to that of AH2 and MP4 cements which both contain Na. The Na and F uptake was much lower than for LG30 whereas that of LG26 was higher than LG30. The Na:F ratio was 0.29:1 compared to 1.26:1 for LG30 (LG26=1.01:1, AH2=1.02:1, MP4=1.04:1). Fluoride addition to a F-free glass ionomer renders it vulnerable to surface disruption by NaF solution showing that fluoride complexes produced in glass dissolution are not necessarily involved in this process. Sodium addition to a Na-free glass ionomer confirms the role of this cement in enhancing pH change in NaF solution. The level of uptake of F- from a NaF solution in much lower than that for the F-free glass ionomer which shows there is no direct relationship between F- uptake and surface disruption. The ratio of Na:F uptake is below 0.3:1, but the pH change is similar to cements where the ratio is close to unity which indicates that F-/OH- interchange is not a significant mechanism even when anion/cation uptake is not balanced. Copyright (C) 2000

Controls on the width of tropical precipitation and its contraction under global warming

AD and ARA were funded by the National Science Foundation Paleo Perspective on Climate Change (P2C2) Grant number AGS-1702827.Climate models robustly and unanimously simulate narrowing of the intense tropical precipitation under greenhouse gas forcing. We argue that the meridional width of tropical precipitation is controlled by the seasonal meridional range of the intertropical convergence zone (ITCZ). The contraction of tropical precipitation under greenhouse forcing results from a reduced seasonal range of ITCZ migration. An energetic theory -- similar to the energetic theory for ITCZ shifts based on the hemispheric contrast of energy input to the atmosphere-- is developed. The meridional width of tropical precipitation is proportional to the seasonal range of the inter-hemispheric contrast in atmospheric heating divided by the efficiency of atmospheric cross-equatorial heat transport. Climate models are biased toward overly expansive tropical precipitation resulting from an exaggerated seasonal atmospheric heating. The robust contraction of tropical precipitation under global warming results from increased efficiency of inter-hemispheric energy transport consistent with enhanced gross moist stability of the tropical atmosphere.Publisher PDFPeer reviewe

Arrays of Cooper Pair Boxes Coupled to a Superconducting Reservoir: `Superradiance' and `Revival.'

We consider an array of Cooper Pair Boxes, each of which is coupled to a superconducting reservoir by a capacitive tunnel junction. We discuss two effects that probe not just the quantum nature of the islands, but also of the superconducting reservoir coupled to them. These are analogues to the well-known quantum optical effects `superradiance,' and `revival.' When revival is extended to multiple systems, we find that `entanglement revival' can also be observed. In order to study the above effects, we utilise a highly simplified model for these systems in which all the single-electron energy eigenvalues are set to be the same (the strong coupling limit), as are the charging energies of the Cooper Pair Boxes, allowing the whole system to be represented by two large coupled quantum spins. Although this simplification is drastic, the model retains the main features necessary to capture the phenomena of interest. Given the progress in superconducting box experiments over recent years, it is possible that experiments to investigate both of these interesting quantum coherent phenomena could be performed in the forseeable future.Comment: 23 pages, 5 figures Clarifications made as recommended by refere