Curvature-bias corrections using a pseudomass method

Momentum measurements for very high momentum charged particles, such as muons from electroweak vector boson decays, are particularly susceptible to charge-dependent curvature biases that arise from misalignments of tracking detectors. Low momentum charged particles used in alignment procedures have limited sensitivity to coherent displacements of such detectors, and therefore are unable to fully constrain these misalignments to the precision necessary for studies of electroweak physics. Additional approaches are therefore required to understand and correct for these effects. In this paper the curvature biases present at the LHCb detector are studied using the pseudomass method in proton-proton collision data recorded at centre of mass energy √(s)=13 TeV during 2016, 2017 and 2018. The biases are determined using Z→μ + μ - decays in intervals defined by the data-taking period, magnet polarity and muon direction. Correcting for these biases, which are typically at the 10-4 GeV-1 level, improves the Z→μ + μ - mass resolution by roughly 18% and eliminates several pathological trends in the kinematic-dependence of the mean dimuon invariant mass

Single-cell RNA sequencing reveals profibrotic roles of distinct epithelial and mesenchymal lineages in pulmonary fibrosis

Pulmonary fibrosis (PF) is a form of chronic lung disease characterized by pathologic epithelial remodeling and accumulation of extracellular matrix (ECM). To comprehensively define the cell types, mechanisms, and mediators driving fibrotic remodeling in lungs with PF, we performed single-cell RNA sequencing of single-cell suspensions from 10 nonfibrotic control and 20 PF lungs. Analysis of 114,396 cells identified 31 distinct cell subsets/states. We report that a remarkable shift in epithelial cell phenotypes occurs in the peripheral lung in PF and identify several previously unrecognized epithelial cell phenotypes, including a KRT5−/KRT17+ pathologic, ECM-producing epithelial cell population that was highly enriched in PF lungs. Multiple fibroblast subtypes were observed to contribute to ECM expansion in a spatially discrete manner. Together, these data provide high-resolution insights into the complexity and plasticity of the distal lung epithelium in human disease and indicate a diversity of epithelial and mesenchymal cells contribute to pathologic lung fibrosis

Translocação orgânica, produtividade e rendimento de óleo essencial de Mentha piperita L. cultivada em solução nutritiva com variação dos níveis de N, P, K e Mg Organic translocation, productivity and essential oil yield of Mentha piperita L. cultivated in nutrient solution with varying N, P, K and Mg levels

O estudo objetivou avaliar translocação orgânica, índices fisiológicos da análise de crescimento e rendimento do óleo essencial de Mentha piperita L. cultivada em solução nutritiva com variação dos níveis de N, P, K e Mg. Assim, foram avaliados os quatro tratamentos contendo 50% N, P, K, 25% Mg; 50% N, P, K, Mg; 65%N, 50%P, 25%K, 100% Mg e 100% N, P, K, Mg. A translocação orgânica foi avaliada por meio da determinação da razão de massa foliar (RMF) e da distribuição de massa seca para os diferentes órgãos. Os índices fisiológicos razão de área foliar (RAF), área foliar específica (AFE), taxa assimilatória líquida (TAL) e taxa de crescimento relativo (TCR) derivadas que compõem a análise de crescimento foram estimados pelo programa ANACRES, após ajuste exponencial quadrático da área foliar e massa seca de lâminas foliares e total da planta em relação ao tempo. O rendimento do óleo essencial, em porcentagem, foi calculado após extração da parte aérea por hidrodestilação. As plantas submetidas ao tratamento com nível completo de nutrientes (100%N/P/K/Mg) exportaram com menor eficiência o material orgânico a partir da folha e a RMF mostrou queda mais lenta, devido à retenção desse material por mais tempo no local de sua produção. Além disso, não apresentaram melhor produtividade e as curvas da TAL e TCR mostraram quedas mais lentas. As plantas submetidas ao tratamento com 65%N/50%P/25%K/100%Mg revelaram adequada exportação de matéria orgânica da folha para caule e pecíolos, conforme demonstra a RMF e a distribuição de massa seca para esses órgãos. Revelaram ainda a RAF mais elevada no inicio do desenvolvimento e mais baixa aos 94 DAT, indicando sombreamento das folhas como resultado de seu crescimento. A AFE dessas plantas mostrou menor variação durante o ciclo, refletindo espessura mais constante de suas folhas. A TAL e a TCR apresentaram curvas decrescentes, com quedas bem acentuadas em relação às demais plantas. Todos esses índices indicam melhor produtividade das plantas submetidas ao tratamento 65%N/50%P/25%K/100%Mg, que também apresentaram rendimento de óleo essencial, em média, maior durante o ciclo. Conclui-se que a redução de 35% de N, 50% de P, 75% de K (65%N/50%P/25%K/100%Mg) é indicada para o cultivo e extração de óleo essencial de M. piperita.<br>This study aimed to evaluate organic translocation, physiologic indexes of growth analysis and essential oil yield of Mentha piperita L. cultivated in nutrient solution with varying levels of N, P, K and Mg. Thus, four treatments were evaluated: 50% N, P, K, 25% Mg; 50% N, P, K, Mg; 65% N, 50% P, 25% K, 100% Mg; and 100% N, P, K, Mg. Organic translocation was assessed through leaf mass ratio (LMR) and dry matter distribution to the different organs. The physiologic indexes leaf area ratio (LAR), specific leaf area (SLA), net assimilation rate (NAR) and relative growth rate (RGR), derived from growth analysis, were estimated using the software ANACRES, following the quadratic exponential fitting of leaf area and dry mass of leaves and total plant, relative to time. Essential oil yield was calculated as percentage after extraction from shoot using hydrodistillation. Plants subjected to the treatment with complete level of nutrients (100%N/P/K/Mg) less efficiently exported organic material from the leaf and LMR showed slower decrease due to the longer retention of such material in its production site. Besides, those plants did not present higher productivity and NAR and RGR curves showed slower decrease. Plants subjected to the treatment with 65%N/50%P/25%K/100%Mg had adequate organic matter exportation from the leaves to the stem and petioles, as demonstrated by LMR and dry matter distribution to these organs. Also in these plants, LAR was higher at the initial development and lower at 94 DAT, indicating leaf shading as a result of growth, and SLA showed less variation during the cycle, reflecting more homogeneous leaf thickness. NAR and RGR had decreasing curves, with marked falls relative to the remaining plants. All these indexes indicate higher productivity of plants subjected to the treatment with 65%N/50%P/25%K/100%Mg, which also had higher essential oil yield, on average, during the cycle. In conclusion, 35% reduction for N, 50% for P, 75% for K (65%N/50%P/25%K/100%Mg) is recommended for cultivation and essential oil extraction of M. piperita