Social Brain Development in Williams Syndrome: The Current Status and Directions for Future Research

Williams syndrome (WS) is a neurodevelopmental condition that occurs as a result of a contiguous deletion of ∼26–28 genes on chromosome 7q11.23. WS is often associated with a distinctive social phenotype characterized by an increased affinity toward processing faces, reduced sensitivity to fear related social stimuli and a reduced ability to form concrete social relationships. Understanding the biological mechanisms that underlie the social phenotype in WS may elucidate genetic and neural factors influencing the typical development of the social brain. In this article, we review available studies investigating the social phenotype of WS throughout development and neuroimaging studies investigating brain structure and function as related to social and emotional functioning in this condition. This review makes an important contribution by highlighting several neuro-behavioral mechanisms that may be a cause or a consequence of atypical social development in WS. In particular, we discuss how distinctive social behaviors in WS may be associated with alterations or delays in the cortical representation of faces, connectivity within the ventral stream, structure and function of the amygdala and how long- and short-range connections develop within the brain. We integrate research on typical brain development and from existing behavioral and neuroimaging research on WS. We conclude with a discussion of how genetic and environmental factors might interact to influence social brain development in WS and how future neuroimaging and behavioral research can further elucidate social brain development in WS. Lastly, we describe how ongoing studies may translate to improved social developmental outcomes for individuals with WS

Manufacturing checkout of orbital operational stages Midterm report, period ending 24 Feb. 1965

Manufacturing checkout of orbital operational Saturn S-IVB stage and instrument unit for parking orbit operation

Frobenius theorem and invariants for Hamiltonian systems

We apply Frobenius integrability theorem in the search of invariants for one-dimensional Hamiltonian systems with a time-dependent potential. We obtain several classes of potential functions for which Frobenius theorem assures the existence of a two-dimensional foliation to which the motion is constrained. In particular, we derive a new infinite class of potentials for which the motion is assurately restricted to a two-dimensional foliation. In some cases, Frobenius theorem allows the explicit construction of an associated invariant. It is proven the inverse result that, if an invariant is known, then it always can be furnished by Frobenius theorem

The uniting of Europe and the foundation of EU studies: revisiting the neofunctionalism of Ernst B. Haas

This article suggests that the neofunctionalist theoretical legacy left by Ernst B. Haas is somewhat richer and more prescient than many contemporary discussants allow. The article develops an argument for routine and detailed re-reading of the corpus of neofunctionalist work (and that of Haas in particular), not only to disabuse contemporary students and scholars of the normally static and stylized reading that discussion of the theory provokes, but also to suggest that the conceptual repertoire of neofunctionalism is able to speak directly to current EU studies and comparative regionalism. Neofunctionalism is situated in its social scientific context before the theory's supposed erroneous reliance on the concept of 'spillover' is discussed critically. A case is then made for viewing Haas's neofunctionalism as a dynamic theory that not only corresponded to established social scientific norms, but did so in ways that were consistent with disciplinary openness and pluralism

Nutrient limitation in the Chesapeake Bay : nutrient bioassays in the Virginia Bay system: final report

Nutrient enrichment bioassays were conducted on water samples collected from six stations in the Virginia portion of the Chesapeake Bay system on a monthly basis over a year. Two stations were located in the tidal freshwater portions of the Rappahannock and James Rivers, at the mouths of these rivers and in the mainstem of the Bay. The purpose of the experiments was to determine the spatial and temporal pattern of nutrient limitation of phytoplankton growth

Mode-sum regularization of the scalar self-force: Formulation in terms of a tetrad decomposition of the singular field

We examine the motion in Schwarzschild spacetime of a point particle endowed with a scalar charge. The particle produces a retarded scalar field which interacts with the particle and influences its motion via the action of a self-force. We exploit the spherical symmetry of the Schwarzschild spacetime and decompose the scalar field in spherical-harmonic modes. Although each mode is bounded at the position of the particle, a mode-sum evaluation of the self-force requires regularization because the sum does not converge: the retarded field is infinite at the position of the particle. The regularization procedure involves the computation of regularization parameters, which are obtained from a mode decomposition of the Detweiler-Whiting singular field; these are subtracted from the modes of the retarded field, and the result is a mode-sum that converges to the actual self-force. We present such a computation in this paper. There are two main aspects of our work that are new. First, we define the regularization parameters as scalar quantities by referring them to a tetrad decomposition of the singular field. Second, we calculate four sets of regularization parameters (denoted schematically by A, B, C, and D) instead of the usual three (A, B, and C). As proof of principle that our methods are reliable, we calculate the self-force acting on a scalar charge in circular motion around a Schwarzschild black hole, and compare our answers with those recorded in the literature.Comment: 38 pages, 2 figure

Interplay of size and Landau quantizations in the de Haas-van Alphen oscillations of metallic nanowires

We examine the interplay between size quantization and Landau quantization in the De Haas-Van Alphen oscillations of clean, metallic nanowires in a longitudinal magnetic field for `hard' boundary conditions, i.e. those of an infinite round well, as opposed to the `soft' parabolically confined boundary conditions previously treated in Alexandrov and Kabanov (Phys. Rev. Lett. {\bf 95}, 076601 (2005) (AK)). We find that there exist {\em two} fundamental frequencies as opposed to the one found in bulk systems and the three frequencies found by AK with soft boundary counditions. In addition, we find that the additional `magic resonances' of AK may be also observed in the infinite well case, though they are now damped. We also compare the numerically generated energy spectrum of the infinite well potential with that of our analytic approximation, and compare calculations of the oscillatory portions of the thermodynamic quantities for both models.Comment: Title changed, paper streamlined on suggestion of referrees, typos corrected, numerical error in figs 2 and 3 corrected and final result simplified -- two not three frequencies (as in the previous version) are observed. Abstract altered accordingly. Submitted to Physical Review