Central Adiposity Is an Independent Risk Factor for Low Vitamin D Among Adults With Cerebral Palsy

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/146958/1/pmr2s149b.pd

Perioperative platelet rich plasma (PRP) in total hip arthroplasty through the Hardinge approach: protocol to study the effectiveness for gluteus medius healing

Peer reviewe

Perioperative platelet rich plasma (PRP) in total hip arthroplasty through the Hardinge approach : protocol to study the effectiveness for gluteus medius healing

Abstract Background Platelet-rich plasma (PRP) has been used to support tendon regeneration mainly in sports medicine. PRP is a concentrate of platelet-rich plasma proteins derived from whole blood by centrifugation to remove erythrocytes and leukocytes. PRP has high amounts of platelets which may promote healing tendons affected by degenerative conditions. These platelets contain growth factors and are known to facilitate the regeneration of injured tendon structures. Total hip arthroplasty (THA) through the Hardinge approach may leave the patient with impaired gait and poor regeneration of the gluteus medius tendon if the tendon is not reattached properly after closure of the surgical wound. Methods The study will be a multicenter, double-blinded and randomized study enrolling 90 patients based on power calculations. The efficacy of perioperative PRP treatment will be assessed by subjective and objective outcome variables. The participants will be randomized (sealed envelope) into either a placebo (saline) or a PRP group (1:1). For subjective outcomes, the Oxford Hip Score (OHS) will be collected before surgery and 3 and 12 months after surgery. The objective measures are findings at magnetic resonance imaging and plain radiographs and recorded values of measured strength. Discussion We present the perioperative use and the ways to measure the clinical efficacy of PRP. As PRP may have benefits regarding degenerative tendon regeneration, studies on the use of PRP in hip arthroplasty are warranted to facilitate postoperative recovery. Trial registration This study has been approved by the ethics committee of the Hospital District of Southwest Finland and approved by the local institutional research board. The study has been registered in ClinicalTrials.gov ( NCT02607462 )

Leg joint power output during progressive resistance FES-LCE cycling in SCI subjects: developing an index of fatigue

This is an Open Access article distributed under the terms of the Creative Commons Attribution Licens

Poster 213: Health and Function Data From an Adult Cerebral Palsy Clinic: Initial Report

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/146951/1/pmr2s196.pd

Shilla growth guidance compared with magnetically controlled growing rods in the treatment of neuromuscular and syndromic early-onset scoliosis

Peer reviewe

Chondroprotective Effect of Kartogenin on CD44-Mediated Functions in Articular Cartilage and Chondrocytes

OBJECTIVE: A recent report identified the small molecule kartogenin as a chondrogenic and chondroprotective agent. Since changes in hyaluronan metabolism occur during cartilage degeneration in osteoarthritis, we began studies to determine whether there was a connection between extracellular hyaluronan, CD44–hyaluronan interactions and the effects of kartogenin on articular chondrocytes. METHODS: Chondrocytes cultured in monolayers, bioengineered neocartilages, or cartilage explants were treated with kartogenin with or without stimulation by IL-1β. Accumulation of matrix was visualized by a particle exclusion assay or by safranin O staining and release of sulfated glycosaminoglycans was determined. Production of aggrecanases and aggrecan G1-ITEGE neoepitope, fragmentation of CD44 and the SMAD1/5/8 signaling pathway were evaluated by western blotting. RESULTS: Kartogenin treatment enhanced chondrocyte pericellular matrix assembly and retention in the presence of IL-1β. The chondroprotective effects of kartogenin on IL-1β-induced release of sulfated glycosaminoglycans from articular cartilage explants, reduction in safranin O staining of neocartilage discs as well as a reduction in aggrecan G1-ITEGE neoepitope in chondrocyte and explant cartilage cultures were observed. Kartogenin partially blocked the IL-1β-induced increased expression of ADAMTS-5. Additionally, kartogenin-treated articular chondrocytes exhibited a decrease in CD44 proteolytic fragmentation. However, kartogenin treatment did not enhance proteoglycan in control, non-IL-1β-treated cultures. Similarly, kartogenin enhanced the SMAD1 phosphorylation but only following pretreatment with IL-1β. CONCLUSION: These studies provide novel information on the chondroprotective function of kartogenin in adult articular cartilage. The effects of kartogenin are significant after activation of chondrocytic chondrolysis, which may occur following disruption of homeostasis maintained by hyaluronan–CD44 interactions

An enhanced sea-ice thermodynamic model applied to the Baltic sea

A refined Semtner 0-layer sea-ice model (ESIM1) is presented and applied to the Baltic landfast sea-ice. The physical model is capable of simulating seasonal changes of snow and ice thickness. Particular attention is paid to reproducing the snow-ice and the super-imposed-ice formation which play important roles in the total mass balance of the Baltic sea-ice. The model prognostic variables include all kinds of ice and snow layers that may be present during a Baltic landfast ice season and, in general, in every coastal area of an ice-covered ocean. The assessment of the model capabilities was done for 1979–1993 for four different stations in the Baltic Sea. A sensitivity test stresses the relevant role of some of the physical parameters, such as the oceanic heat flux, while a scenario analysis highlights the robustness of the model to perturbed physical forcing. Our results show that one of the key variables in modelling sea-ice thermodynamics is the snow layer and its metamorphism, and including the meteoric ice dynamics into a sea ice model is relevant to properly simulate any ice season, also in view of climate change scenario

Variability and changes of Arctic sea ice draft distribution - submarine sonar measurements revisited

Peer reviewe