From Query-By-Keyword to Query-By-Example: LinkedIn Talent Search Approach

One key challenge in talent search is to translate complex criteria of a hiring position into a search query, while it is relatively easy for a searcher to list examples of suitable candidates for a given position. To improve search efficiency, we propose the next generation of talent search at LinkedIn, also referred to as Search By Ideal Candidates. In this system, a searcher provides one or several ideal candidates as the input to hire for a given position. The system then generates a query based on the ideal candidates and uses it to retrieve and rank results. Shifting from the traditional Query-By-Keyword to this new Query-By-Example system poses a number of challenges: How to generate a query that best describes the candidates? When moving to a completely different paradigm, how does one leverage previous product logs to learn ranking models and/or evaluate the new system with no existing usage logs? Finally, given the different nature between the two search paradigms, the ranking features typically used for Query-By-Keyword systems might not be optimal for Query-By-Example. This paper describes our approach to solving these challenges. We present experimental results confirming the effectiveness of the proposed solution, particularly on query building and search ranking tasks. As of writing this paper, the new system has been available to all LinkedIn members

Once Again, is Openness Good for Growth?

Rodriguez and Rodrik (2000) argue that the relation between openness and growth is still an open question. One of the main problems in the assessment of the effect is the endogeneity of the relation. In order to address this issue, this paper applies the identification through heteroskedasticity methodology to estimate the effect of openness on growth while properly controlling for the effect of growth on openness. The results suggest that openness would have a positive effect on growth, although small. This result stands, despite the equally robust effect from growth to openness.

Potential of mean force and the charge reversal of rodlike polyions

A simple model is presented to calculate the potential of mean force between a polyion and a multivalent counterion inside a polyelectrolite solution. We find that under certain conditions the electrostatic interactions can lead to a strong attraction between the polyions and the multivalent counterions, favoring formation of overcharged polyion-counterion complexes. It is found that small concentrations of salt enhance the overcharging, while an excessive amount of salt hinders the charge reversal. The kinetic limitations to overcharging are also examined.Comment: To be published in the special issue of Molecular Physics in honor of Prof. Ben Wido

A unique bleeding-related complication of sorafenib, a tyrosine kinase inhibitor, in advanced hepatocellular carcinoma: a case report

INTRODUCTION: Sorafenib, a multikinase inhibitor as a standard of care for advanced hepatocellular carcinoma, may lead endothelial cells to an unstable state by blocking the signaling pathway of vascular endothelial growth factor receptor, which may result in the disruption of the architecture and integrity of the microvasculature, and eventually increase the risk of hemorrhage. Hemobilia is a relatively uncommon condition as a consequence of hepatocellular carcinoma and its risk factors remain uncertain. CASE PRESENTATION: Here we report a unique case of hemobilia occurring in a 55-year-old Korean man with hepatitis B virus-related hepatocellular carcinoma on Barcelona Clinic Liver Cancer advanced stage after seven days of treatment with sorafenib. He had received prior radiation therapy. Endoscopy revealed bleeding from the major duodenal papilla and endoscopic retrograde cholangiography revealed an amorphous filling defect throughout the common bile duct. Blood clots were removed by balloon sweeping and a nasobiliary drainage tube was placed. No further bleeding has been detected as of eight months after discontinuation of sorafenib. CONCLUSION: Sorafenib may increase the risk of biliary bleeding in hepatocellular carcinoma patients who were primed with irradiation, by blocking the signaling pathway of the vascular endothelial growth factor receptor. Therefore, sorafenib should be used with caution in patients with advanced hepatocellular carcinoma, especially when combined with radiation therapy

High-Performance Multi-Mode Ptychography Reconstruction on Distributed GPUs

Ptychography is an emerging imaging technique that is able to provide wavelength-limited spatial resolution from specimen with extended lateral dimensions. As a scanning microscopy method, a typical two-dimensional image requires a number of data frames. As a diffraction-based imaging technique, the real-space image has to be recovered through iterative reconstruction algorithms. Due to these two inherent aspects, a ptychographic reconstruction is generally a computation-intensive and time-consuming process, which limits the throughput of this method. We report an accelerated version of the multi-mode difference map algorithm for ptychography reconstruction using multiple distributed GPUs. This approach leverages available scientific computing packages in Python, including mpi4py and PyCUDA, with the core computation functions implemented in CUDA C. We find that interestingly even with MPI collective communications, the weak scaling in the number of GPU nodes can still remain nearly constant. Most importantly, for realistic diffraction measurements, we observe a speedup ranging from a factor of $10$ to $10^3$ depending on the data size, which reduces the reconstruction time remarkably from hours to typically about 1 minute and is thus critical for real-time data processing and visualization.Comment: work presented in NYSDS 201

Correlations for the Dyson Brownian motion model with Poisson initial conditions

The circular Dyson Brownian motion model refers to the stochastic dynamics of the log-gas on a circle. It also specifies the eigenvalues of certain parameter-dependent ensembles of unitary random matrices. This model is considered with the initial condition that the particles are non-interacting (Poisson statistics). Jack polynomial theory is used to derive a simple exact expression for the density-density correlation with the position of one particle specified in the initial state, and the position of one particle specified at time $\tau$, valid for all $\beta > 0$. The same correlation with two particles specified in the initial state is also derived exactly, and some special cases of the theoretical correlations are illustrated by comparison with the empirical correlations calculated from the eigenvalues of certain parameter-dependent Gaussian random matrices. Application to fluctuation formulas for time displaced linear statistics in made.Comment: 17 pgs., 2 postscript fig

Does epigenetic polymorphism contribute to phenotypic variances in Jatropha curcas L.?

<p>Abstract</p> <p>Background</p> <p>There is a growing interest in <it>Jatropha curcas </it>L. (jatropha) as a biodiesel feedstock plant. Variations in its morphology and seed productivity have been well documented. However, there is the lack of systematic comparative evaluation of distinct collections under same climate and agronomic practices. With the several reports on low genetic diversity in jatropha collections, there is uncertainty on genetic contribution to jatropha morphology.</p> <p>Result</p> <p>In this study, five populations of jatropha plants collected from China (CN), Indonesia (MD), Suriname (SU), Tanzania (AF) and India (TN) were planted in one farm under the same agronomic practices. Their agronomic traits (branching pattern, height, diameter of canopy, time to first flowering, dormancy, accumulated seed yield and oil content) were observed and tracked for two years. Significant variations were found for all the agronomic traits studied. Genetic diversity and epigenetic diversity were evaluated using florescence Amplified Fragment Length Polymorphism (fAFLP) and methylation sensitive florescence AFLP (MfAFLP) methods. Very low level of genetic diversity was detected (polymorphic band <0.1%) within and among populations. In contrast, intermediate but significant epigenetic diversity was detected (25.3% of bands were polymorphic) within and among populations. More than half of CCGG sites surveyed by MfAFLP were methylated with significant difference in inner cytosine and double cytosine methylation among populations. Principal coordinates analysis (PCoA) based on Nei's epigenetic distance showed Tanzania/India group distinct from China/Indonesia/Suriname group. Inheritance of epigenetic markers was assessed in one F1 hybrid population between two morphologically distinct parent plants and one selfed population. 30 out of 39 polymorphic markers (77%) were found heritable and followed Mendelian segregation. One epiallele was further confirmed by bisulphite sequencing of its corresponding genomic region.</p> <p>Conclusion</p> <p>Our study confirmed climate and practice independent differences in agronomic performance among jatropha collections. Such agronomic trait variations, however, were matched by very low genetic diversity and medium level but significant epigenetic diversity. Significant difference in inner cytosine and double cytosine methylation at CCGG sites was also found among populations. Most epigenetic differential markers can be inherited as epialleles following Mendelian segregation. These results suggest possible involvement of epigenetics in jatropha development.</p