1,307 research outputs found
KMT-2016-BLG-1107: A New Hollywood-Planet Close/Wide Degeneracy
We show that microlensing event KMT-2016-BLG-1107 displays a new type of
degeneracy between wide-binary and close-binary Hollywood events in which a
giant-star source envelops the planetary caustic. The planetary anomaly takes
the form of a smooth, two-day "bump" far out on the falling wing of the light
curve, which can be interpreted either as the source completely enveloping a
minor-image caustic due to a close companion with mass ratio , or
partially enveloping a major-image caustic due to a wide companion with
. The best estimates of the companion masses are both in the planetary
regime ( and ) but differ by an even larger factor than the mass ratios due to
different inferred host masses. We show that the two solutions can be
distinguished by high-resolution imaging at first light on next-generation
("30m") telescopes. We provide analytic guidance to understand the conditions
under which this new type of degeneracy can appear.Comment: 23 pages, 7 figures, accepted for publication in A
KMT-2018-BLG-1292: A Super-Jovian Microlens Planet in the Galactic Plane
We report the discovery of KMT-2018-BLG-1292Lb, a super-Jovian planet orbiting an F or G dwarf , which lies physically within {\cal O}(10\,\pc) of the
Galactic plane. The source star is a heavily extincted luminous
giant that has the lowest Galactic latitude, , of any planetary
microlensing event. The relatively blue blended light is almost certainly
either the host or its binary companion, with the first explanation being
substantially more likely. This blend dominates the light at band and
completely dominates at and bands. Hence, the lens system can be probed
by follow-up observations immediately, i.e., long before the lens system and
the source separate due to their relative proper motion. The system is well
characterized despite the low cadence -- of
observations and short viewing windows near the end of the bulge season. This
suggests that optical microlensing planet searches can be extended to the
Galactic plane at relatively modest cost.Comment: 35 pages, 3 Tables, 8 figure
Clinical Outcome of Magnetic Resonance Imaging-Detected Additional Lesions in Breast Cancer Patients
Purpose: The aim of this study was to investigate the clinical outcome of additional breast lesions identified with breast magnetic resonance imaging (MRI) in breast cancer patients. Methods: A total of 153 patients who underwent breast MRI between July 2006 and March 2008 were retrospectively reviewed. Thirty-three patients (21.6%) were recommended for second-look ultrasound (US) for further characterization of additional lesions detected on breast MRI and these patients constituted our study population. Results: Assessment for lesions detected on breast MRI consisted of the following: 25 benign lesions (73.5%), two indeterminate (5.9%), and seven malignant (20.6%) in 33 patients. Second-look US identified 12 additional lesions in 34 lesions (35.3%) and these lesions were confirmed by histological examination. Of the 12 lesions found in the 11 patients, six (50.0%) including one contralateral breast cancer were malignant. The surgical plan was altered in 18.2 % (six of 33) of the patients. The use of breast MRI justified a change in treatment for four patients (66.7%) and caused two patients (33.3%) to undergo unwarranted additional surgical procedures. Conclusion: Breast MRI identified additional multifocal or contralateral cancer which was not detected initially on conventional imaging in breast cancer patients. Breast MRI has become an indispensable modality in conjunction with conventional modalities for preoperative evaluation of patients with operable breast cancer
Characterization of diverse natural variants of CYP102A1 found within a species of Bacillus megaterium
An extreme diversity of substrates and catalytic reactions of cytochrome P450 (P450) enzymes is considered to be the consequence of evolutionary adaptation driven by different metabolic or environmental demands. Here we report the presence of numerous natural variants of P450 BM3 (CYP102A1) within a species of Bacillus megaterium. Extensive amino acid substitutions (up to 5% of the total 1049 amino acid residues) were identified from the variants. Phylogenetic analyses suggest that this P450 gene evolve more rapidly than the rRNA gene locus. It was found that key catalytic residues in the substrate channel and active site are retained. Although there were no apparent variations in hydroxylation activity towards myristic acid (C14) and palmitic acid (C16), the hydroxylation rates of lauric acid (C12) by the variants varied in the range of >25-fold. Interestingly, catalytic activities of the variants are promiscuous towards non-natural substrates including human P450 substrates. It can be suggested that CYP102A1 variants can acquire new catalytic activities through site-specific mutations distal to the active site
The Comparison of Central and Mean True-Net Power (Pentacam) in Calculating IOL-Power After Refractive Surgery
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