Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors

Background Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic etiology, which is partially shared and partially distinct from that of related psychiatric disorders. Methods We conducted a genome-wide association study (GWAS) of 29,782 suicide attempt (SA) cases and 519,961 controls in the International Suicide Genetics Consortium (ISGC). The GWAS of SA was conditioned on psychiatric disorders using GWAS summary statistics via multitrait-based conditional and joint analysis, to remove genetic effects on SA mediated by psychiatric disorders. We investigated the shared and divergent genetic architectures of SA, psychiatric disorders, and other known risk factors. Results Two loci reached genome-wide significance for SA: the major histocompatibility complex and an intergenic locus on chromosome 7, the latter of which remained associated with SA after conditioning on psychiatric disorders and replicated in an independent cohort from the Million Veteran Program. This locus has been implicated in risk-taking behavior, smoking, and insomnia. SA showed strong genetic correlation with psychiatric disorders, particularly major depression, and also with smoking, pain, risk-taking behavior, sleep disturbances, lower educational attainment, reproductive traits, lower socioeconomic status, and poorer general health. After conditioning on psychiatric disorders, the genetic correlations between SA and psychiatric disorders decreased, whereas those with nonpsychiatric traits remained largely unchanged. Conclusions Our results identify a risk locus that contributes more strongly to SA than other phenotypes and suggest a shared underlying biology between SA and known risk factors that is not mediated by psychiatric disorders.Peer reviewe

A cultural history of Western music

"Music has been significant in social, religious, and political ritual, and in education, art, and entertainment in all human cultures from antiquity to today. The Cultural History of Western Music presents the first study of music in all its forms - ritual, classical, popular and commercial - from antiquity to today. The work is divided into 6 volumes, with each volume covering the same topics, so readers can either study a period/volume or follow a topic across history. The volumes are: 1. A Cultural History of Western Music in Antiquity 2. A Cultural History of Western Music in the Middle Ages 3. A Cultural History of Western Music in the Renaissance 4. A Cultural History of Western Music in the Age of Enlightenment 5. A Cultural History of Western Music in the Industrial Age 6. A Cultural History of Western Music in the Modern Age. The topics are identity, communities and society; changing philosophies and ideas about music; politics and power; musical exchange and knowledge transfer between the West and the non-West; musical education; popular culture and musical entertainment; the places, practices, and experiences of performance; and the development of music technologies and media. The page extent for the pack is approximately 1536 pp. Each volume opens with Notes on Contributors and an Introduction and concludes with Notes, Bibliography, and an Index"-- Includes bibliographical references and inde