2,963 research outputs found
Actively Contracting Bundles of Polar Filaments
We introduce a phenomenological model to study the properties of bundles of
polar filaments which interact via active elements. The stability of the
homogeneous state, the attractors of the dynamics in the unstable regime and
the tensile stress generated in the bundle are discussed. We find that the
interaction of parallel filaments can induce unstable behavior and is
responsible for active contraction and tension in the bundle. Interaction
between antiparallel filaments leads to filament sorting. Our model could apply
to simple contractile structures in cells such as stress fibers.Comment: 4 pages, 4 figures, RevTex, to appear in Phys. Rev. Let
Propagation of tau pathology in Alzheimer’s disease: identification of novel therapeutic targets
Accumulation and aggregation of the microtubule-associated protein tau are a pathological hallmark of neurodegenerative disorders such as Alzheimer’s disease (AD). In AD, tau becomes abnormally phosphorylated and forms inclusions throughout the brain, starting in the entorhinal cortex and progressively affecting additional brain regions as the disease progresses. Formation of these inclusions is thought to lead to synapse loss and cell death. Tau is also found in the cerebrospinal fluid (CSF), and elevated levels are a biomarker for AD. Until recently, it was thought that the presence of tau in the CSF was due to the passive release of aggregated tau from dead or dying tangle-bearing neurons. However, accumulating evidence from different AD model systems suggests that tau is actively secreted and transferred between synaptically connected neurons. Transgenic mouse lines with localized expression of aggregating human tau in the entorhinal cortex have demonstrated that, as these animals age, tau becomes mislocalized from axons to cell bodies and dendrites and that human tau-positive aggregates form first in the entorhinal cortex and later in downstream projection targets. Numerous in vitro and in vivo studies have provided insight into the mechanisms by which tau may be released and internalized by neurons and have started to provide insight into how tau pathology may spread in AD. In this review, we discuss the evidence for regulated tau release and its specific uptake by neurons. Furthermore, we identify possible therapeutic targets for preventing the propagation of tau pathology, as inhibition of tau transfer may restrict development of tau tangles in a small subset of neurons affected in early stages of AD and therefore prevent widespread neuron loss and cognitive dysfunction associated with later stages of the disease
A powerful bursting radio source towards the Galactic Centre
Transient astronomical sources are typically powered by compact objects and
usually signify highly explosive or dynamic events. While radio astronomy has
an impressive record of obtaining high time resolution observations, usually it
is achieved in quite narrow fields-of-view. Consequently, the dynamic radio sky
is poorly sampled, in contrast to the situation in the X- and gamma-ray bands
in which wide-field instruments routinely detect transient sources. Here we
report a new transient source, GCRT J1745-3009, detected in 2002 during a
moderately wide-field radio transient monitoring program of the Galactic center
(GC) region at 0.33 GHz. The characteristics of its bursts are unlike those
known for any other class of radio transient. If located in or near the GC, its
brightness temperature (~10^16 K) and the implied energy density within GCRT
J1745-3009 vastly exceeds that observed in most other classes of radio
astronomical sources, and is consistent with coherent emission processes rarely
observed. We conclude that GCRT J1745-3009 is the first member of a new class
of radio transient sources, the first of possibly many new classes to be
identified through current and upcoming radio surveys.Comment: 16 pages including 3 figures. Appears in Nature, 3 March 200
Numerical renormalization-group study of spin correlations in one-dimensional random spin chains
We calculate the ground-state two-spin correlation functions of spin-1/2
quantum Heisenberg chains with random exchange couplings using the real-space
renormalization group scheme. We extend the conventional scheme to take account
of the contribution of local higher multiplet excitations in each decimation
step. This extended scheme can provide highly accurate numerical data for large
systems. The random average of staggered spin correlations of the chains with
random antiferromagnetic (AF) couplings shows algebraic decay like ,
which verifies the Fisher's analytic results. For chains with random
ferromagnetic (FM) and AF couplings, the random average of generalized
staggered correlations is found to decay more slowly than a power-law, in the
form close to . The difference between the distribution functions of
the spin correlations of the random AF chains and of the random FM-AF chains is
also discussed.Comment: 14 pages including 8 figures, REVTeX, submitted to Physical Review
Numerical studies of the 2 and 3D gauge glass at low temperature
We report results from Monte Carlo simulations of the two- and
three-dimensional gauge glass at low temperature using parallel tempering Monte
Carlo. In two dimensions, we find strong evidence for a zero-temperature
transition. By means of finite-size scaling, we determine the stiffness
exponent theta = -0.39 +/- 0.03. In three dimensions, where a
finite-temperature transition is well established, we find theta = 0.27 +/-
0.01, compatible with recent results from domain-wall renormalization group
studies.Comment: 3 pages, 3 figures. Proceedings of "2002 MMM Conference", Tampa, F
Beta-decay branching ratios of 62Ga
Beta-decay branching ratios of 62Ga have been measured at the IGISOL facility
of the Accelerator Laboratory of the University of Jyvaskyla. 62Ga is one of
the heavier Tz = 0, 0+ -> 0+ beta-emitting nuclides used to determine the
vector coupling constant of the weak interaction and the Vud quark-mixing
matrix element. For part of the experimental studies presented here, the
JYFLTRAP facility has been employed to prepare isotopically pure beams of 62Ga.
The branching ratio obtained, BR= 99.893(24)%, for the super-allowed branch is
in agreement with previous measurements and allows to determine the ft value
and the universal Ft value for the super-allowed beta decay of 62Ga
Correlated Gravitational Wave and Neutrino Signals from General-Relativistic Rapidly Rotating Iron Core Collapse
We present results from a new set of 3D general-relativistic hydrodynamic
simulations of rotating iron core collapse. We assume octant symmetry and focus
on axisymmetric collapse, bounce, the early postbounce evolution, and the
associated gravitational wave (GW) and neutrino signals. We employ a
finite-temperature nuclear equation of state, parameterized electron capture in
the collapse phase, and a multi-species neutrino leakage scheme after bounce.
The latter captures the important effects of deleptonization, neutrino cooling
and heating and enables approximate predictions for the neutrino luminosities
in the early evolution after core bounce. We consider 12-solar-mass and
40-solar-mass presupernova models and systematically study the effects of (i)
rotation, (ii) progenitor structure, and (iii) postbounce neutrino leakage on
dynamics, GW, and, neutrino signals. We demonstrate, that the GW signal of
rapidly rotating core collapse is practically independent of progenitor mass
and precollapse structure. Moreover, we show that the effects of neutrino
leakage on the GW signal are strong only in nonrotating or slowly rotating
models in which GW emission is not dominated by inner core dynamics. In rapidly
rotating cores, core bounce of the centrifugally-deformed inner core excites
the fundamental quadrupole pulsation mode of the nascent protoneutron star. The
ensuing global oscillations (f~700-800 Hz) lead to pronounced oscillations in
the GW signal and correlated strong variations in the rising luminosities of
antineutrino and heavy-lepton neutrinos. We find these features in cores that
collapse to protoneutron stars with spin periods <~ 2.5 ms and rotational
energies sufficient to drive hyper-energetic core-collapse supernova
explosions. Hence, joint GW + neutrino observations of a core collapse event
could deliver strong evidence for or against rapid core rotation. [abridged]Comment: 29 pages, 14 figures. Replaced with version matching published
versio
Islands Containing Slowly Hydrolyzable GTP Analogs Promote Microtubule Rescues
Microtubules are dynamic polymers of GTP- and GDP-tubulin that undergo stochastic transitions between growing and shrinking phases. Rescues, the conversion from shrinking to growing, have recently been proposed to be to the result of regrowth at GTP-tubulin islands within the lattice of growing microtubules. By introducing mixed GTP/GDP/GMPCPP (GXP) regions within the lattice of dynamic microtubules, we reconstituted GXP islands in vitro (GMPCPP is the slowly hydrolyzable GTP analog guanosine-5′-[(α,β)-methyleno]triphosphate). We found that such islands could reproducibly induce rescues and that the probability of rescue correlated with both the size of the island and the percentage of GMPCPP-tubulin within the island. The islands slowed the depolymerization rate of shortening microtubules and promoted regrowth more readily than GMPCPP seeds. Together, these findings provide new mechanistic insights supporting the possibility that rescues could be triggered by enriched GTP-tubulin regions and present a new tool for studying such rescue events in vitro
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