67 research outputs found
No evidence of an association between mitochondrial DNA variants and osteoarthritis in 7393 cases and 5122 controls.
OBJECTIVES: Osteoarthritis (OA) has a complex aetiology with a strong genetic component. Genome-wide association studies implicate several nuclear genes in the aetiology, but a major component of the heritability has yet to be defined at the molecular level. Initial studies implicate maternally inherited variants of mitochondrial DNA (mtDNA) in subgroups of patients with OA based on gender and specific joint involvement, but these findings have not been replicated.
METHODS: The authors studied 138 maternally inherited mtDNA variants genotyped in a two cohort genetic association study across a total of 7393 OA cases from the arcOGEN consortium and 5122 controls genotyped in the Wellcome Trust Case Control consortium 2 study.
RESULTS: Following data quality control we examined 48 mtDNA variants that were common in cohort 1 and cohort 2, and found no association with OA. None of the phenotypic subgroups previously associated with mtDNA haplogroups were associated in this study.
CONCLUSIONS: We were not able to replicate previously published findings in the largest mtDNA association study to date. The evidence linking OA to mtDNA is not compelling at present
Perdas de solo e água em entressulcos em um Argissolo Vermelho-Amarelo submetido a quatro padrões de chuva
Padrões de precipitação e índices de erosividade para as chuvas de Seropédica e Nova Friburgo, RJ
Relações entre tamanho de sedimentos erodidos, velocidade da enxurrada, rugosidade superficial criada pelo preparo e tamanho de agregados em solo submetido a diferentes manejos
Importantes características de chuva para a conservação do solo e da água no município de São Manuel (SP)
Rainfall erosivity and rainfall return period in the experimental watershed of Aracruz, in the coastal plain of Espirito Santo, Brazil
Erosividade das chuvas e sua distribuição entre 1989 e 1998 no município de Lages (SC)
Redução da erosão hídrica em três sistemas de manejo do solo em um Cambissolo Húmico da região do Planalto Sul-Catarinense
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