Zooplankton-associated and free-living bacteria in the York River, Chesapeake Bay: comparison of seasonal variations and controlling factors

Trace caches deliver a high number of instructions per cycle to wide-issue superscalar processors. To overcome complex control flow, multiple branch predictors have to predict up to 3 conditional branches per cycle. These multiple branch predictors sometimes predict completely wrong paths of execution, degrading the average fetch bandwidth. This paper shows that such mispredictions can be detected by monitoring trace cache misses. Based on this observation, a new technique called trace substitution is introduced. On a trace cache miss, trace substitution overrides the predicted trace with a cached trace. If the substitution is correct, the fetch bandwidth increases. We show that trace substitution consistently improves the fetch bandwidth with 0.2 instructions per access. For inaccurate predictors, trace substitution can increase the fetch bandwidth with up to 2 instructions per access

Bio-responsive polymer hydrogels homeostatically regulate blood coagulation

Bio-responsive polymer architectures can empower medical therapies by engaging molecular feedback-response mechanisms resembling the homeostatic adaptation of living tissues to varying environmental constraints. Here we show that a blood coagulation-responsive hydrogel system can deliver heparin in amounts triggered by the environmental levels of thrombin, the key enzyme of the coagulation cascade, which—in turn—becomes inactivated due to released heparin. The bio-responsive hydrogel quantitatively quenches blood coagulation over several hours in the presence of pro-coagulant stimuli and during repeated incubation with fresh, non-anticoagulated blood. These features enable the introduced material to provide sustainable, autoregulated anticoagulation, addressing a key challenge of many medical therapies. Beyond that, the explored concept may facilitate the development of materials that allow the effective and controlled application of drugs and biomolecules