Acceptance of Flu Vaccine among Parents of Diabetic Children in Jordan

Abstract: There is a critical need to understand vaccine decision-making in high-risk groups. This study explored flu vaccine acceptance among Jordanian parents of diabetic children. Employing a cross-sectional approach, 405 parents from multiple healthcare centers across Jordan were recruited through stratified sampling, ensuring a broad representation of socioeconomic backgrounds. A structured questionnaire, distributed both in-person and online, evaluated their knowledge, attitudes, and acceptance of the flu vaccine for their diabetic children. The results indicated that only 6.4% of the study sample reported vaccinating their children against the flu annually, and only 23% are planning to vaccinate their children this year. A multinomial logistic regression analysis revealed notable variability in responses. Specifically, parents with a positive attitude towards the flu vaccine and those with older children had less odds to reject the vaccine (OR = 0.589, 95% CI (0.518–0.670), p &lt; 0.001 and OR = 0.846, 95% CI (0.736–0.974), p = 0.02, respectively). Conversely, prevalent misconceptions regarding vaccine safety and efficacy emerged as significant barriers to acceptance.Our findings advocate for targeted educational programs that directly address and debunk these specific misconceptions. Additionally, strengthened healthcare communication to provide clear, consistent information about the flu vaccine’s safety and benefits is vital to help enhance vaccine uptake among this vulnerable population, emphasizing the need to address specific concerns and misinformation directly.</div

Predicting Fire Alarms in Smoke Detection using Neural Networks

Abstract: This research paper presents the development and evaluation of a neural network-based model for predicting fire alarms in smoke detection systems. Using a dataset from Kaggle containing 15 features and 3487 samples, we trained and validated a neural network with a three-layer architecture. The model achieved an accuracy of 100% and an average error of 0.0000003. Additionally, we identified the most influential features in predicting fire alarms

Marginal and Internal Crown Fit Evaluation of CAD/CAM versus Press-Laboratory Lithium Disilicate Crown

This study aims to evaluate the marginal gap and internal adaptation of lithium disilicate crowns fabricated by conventional press-dental laboratory and CAD/CAM systems. The size of the marginal and internal gaps of crowns is fabricated with the two techniques in the current study; the research will be performed in an effort to improve clinical outcomes. Tooth #14 was prepared per standard specification to receive the lithium disilicate crowns. Sixty Type IV gypsum dies tooth #14 were duplicated and divided into three groups (n=30). The lithium disilicate CAD/CAM system (Group 1) was fabricated with the E4D CAD/CAM system according to manufacturer's instructions. For press-dental laboratory made crowns, impressions were taken on the region area with two-step impression techniques with light and putty consistency VPS. Impressions were sent to two independent dental laboratories (Groups 2 and 3) for fabricating the monolithic press lithium disilicate crown. Tooth #14 was optically scanned and lithium disilicate blocks were used to fabricate crowns using CAD/CAM technique. Polyvinyl siloxane impressions of the prepared teeth were made and monolithic pressed lithium disilicate crowns were fabricated. The marginal gap was measured using optical microscope at 160× magnification (Keyence VHX-5000, Japan) and internal fit of the crowns was assessed by the silicone replica technique. Four sections of each replica were obtained, and each section was evaluated at four points: marginal gap (MG), axial wall (AW), axio-occlusal edge (AO) and Centro-occlusal wall (CO), using an image analyzing software. Statistical analysis was performed using ANOVA and chi-squared test. Study design: Experimental. Setting of study: University of Palestine and Laser Specialized center For Esthetic Dentistry

Otro título: [Testimonios sobre la colección de la Biblioteca Islámica]

Video promocional sobre la exposición conmemorativa del Premio Unesco-Sharjah 2015 y los Tesoros de la Biblioteca IslámicaPresentación: Luisa Mora Villarejo. Testimonios: Miguel Hernando de Larramendi, Rachid El Hour, Nuria Martínez de Castilla, Pablo García Suárez, Fajri Al-Wasif, Fernando de Ágreda, Nuria Torres Santo Domingo. Música con licencia Creative Commons: “Zeffa" by Alialujah Choir: Hicham ChahidiTipo de archivo: Imagen y sonidoMadrid, 21 de mayo de 2015 a las 11.30 en el Salón de Actos de la AECIDFormato mp4Premios: Premio UNESCO-Sharjah para la cultura árabe (2015

Combination of Carmustine and Selenite Inhibits EGFR Mediated Growth Signaling in Androgen-Independent Prostate Cancer Cells

Although aberrant androgen receptor (AR) signaling is a central mechanism for castration resistant prostate cancer (CRPC) progression, AR-independent growth signaling is also present in CRPC. The current therapeutic options for patients with CRPC are limited and new drugs are desperately needed to eliminate these crucial growth signaling pathways. We have previously shown that combination of carmustine and selenite effectively induces apoptosis and growth inhibition by targeting AR and AR-variants in CRPC cells. High levels of EGFR expression present in the CRPC cells mediates the cell proliferation via AR-independent growth signaling mechanisms. Therefore, in this study, we investigated whether the combination of carmustine and selenite could inhibit EGFR mediated growth signaling and induce apoptosis in androgen independent-AR negative prostate cancer cells. EGF exposure dose and time dependently increased phospho-EGFR (Tyr845, Tyr1068, and Tyr1045), pAkt (Ser473), and pERK1/2 (Thr204/Tyr202) protein expression levels in AIPC cells. Combination of carmustine and selenite treatment markedly suppressed EGF-stimulated proliferation and survival of AIPC cells and effectively induced apoptosis. The ROS generated by the combination of carmustine and selenite exhibited a strong inhibition on EGF stimulated EGFR and its downstream signaling molecules such as Akt, NF-kB, ERK1/2, and Cyclin D1. Individual agent treatment showed only partial effect. Overall, our findings demonstrated that the combination of carmustine and selenite treatment dramatically inhibits EGFR signaling, proliferation, and induces apoptosis in AIPC cells, suggesting a potential candidate for the treatment of CRPC. The results of the study further suggest that the combination of carmustine and selenite treatment can overcome EGFR mediated AR-independent growth response in CRPC during anti-androgen therapy. J. Cell. Biochem. 118: 4331-4340, 2017. © 2017 Wiley Periodicals, Inc