1,377 research outputs found
Critical Micronutrients in Pregnancy, Lactation, and Infancy: Considerations on Vitamin D, Folic Acid, and Iron, and Priorities for Future Research
The Early Nutrition Academy and the European Commission-funded EURRECA Network of Excellence jointly sponsored a scientific workshop on critical micronutrients in pregnancy, lactation, and infancy. Current knowledge and unresolved questions on the supply of vitamin D, folic acid, and iron for pregnant women, lactating women, and infants, and their health effects were discussed. The question was addressed of whether, and under which circumstances, supplementation with these micronutrients in addition to usual dietary intakes is advisable. The workshop participants concluded that public health strategies for improving supplementation with these micronutrients in pregnancy, lactation, and infancy are required. Further research priorities should focus on adequately powered human intervention trials to obtain a stronger evidence base for the amounts of vitamin D, folic acid, and iron that have optimal effects on health. The conclusions of the workshop should help to inform the scientific community as well as public health policy strategies. Copyright (C) 2011 S. Karger AG, Base
New generalized nonspherical black hole solutions
We present numerical evidence for the existence of several types of static
black hole solutions with a nonspherical event horizon topology in
spacetime dimensions. These asymptotically flat configurations are found for a
specific metric ansatz and can be viewed as higher dimensional counterparts of
the static black rings, dirings and black Saturn. Similar to that case,
they are supported against collapse by conical singularities. The issue of
rotating generalizations of these solutions is also considered.Comment: 47 pages, 11 figures, some comments adde
Evaluation of the influence of kyphosis and scoliosis on intervertebral disc extrusion in French bulldogs
Although thoracic vertebral malformations with kyphosis and scoliosis are often considered incidental findings on diagnostic imaging studies of screw-tailed brachycephalic breeds, they have been suggested to interfere with spinal biomechanics and intervertebral disc degeneration. It is however unknown if an abnormal spinal curvature also predisposes dogs to develop clinically relevant intervertebral disc herniations. The aim of this study was to evaluate if the occurrence of thoracic vertebral malformations, kyphosis or scoliosis would be associated with a higher prevalence of cervical or thoracolumbar intervertebral disc extrusion in French bulldogs
Three-year efficacy, safety, and survival findings from COMFORT-II, a phase 3 study comparing ruxolitinib with best available therapy for myelofibrosis.
Loss of Developmental Diapause as Prerequisite for Social Evolution in Bees
Diapause is a physiological arrest of development ahead of adverse environmental conditions and is a critical phase of the life cycle of many insects. In bees, diapause has been reported in species from all seven taxonomic families. However, they exhibit a variety of diapause strategies. These different strategies are of particular interest since shifts in the phase of the insect life cycle in which diapause occurs have been hypothesized to promote the evolution of sociality. Here we provide a comprehensive evaluation of this hypothesis with phylogenetic analysis and ancestral state reconstruction (ASR) of the ecological and evolutionary factors associated with diapause phase. We find that social lifestyle, latitude and voltinism are significant predictors of the life stage in which diapause occurs. ASR revealed that the most recent common ancestor of all bees likely exhibited developmental diapause and shifts to adult, reproductive, or no diapause have occurred in the ancestors of lineages in which social behaviour has evolved. These results provide fresh insight regarding the role of diapause as a prerequisite for the evolution of sociality in bees
In silico analysis of candidate genes associated with humoral innate immune response in chicken
"Mushroom cloud": a giant left ventricular pseudoaneurysm after a myocardial infarction due to myocardial bridging – a case report
Left ventricular pseudoaneurysm is an uncommon complication after transmural myocardial infarction, occurring when a free wall rupture is contained by adhesions of the overlying pericardium preventing acute tamponade. In this report, an unusual case of a 61 year-old male with a giant apical left ventricular pseudoaneurysm after an unnoticed myocardial infarction is presented. On coronary angiogram myocardial bridging of the distal left anterior descending artery was judged to be the infarct related lesion. The echocardiographic diagnosis allowed for a timely surgical intervention which resulted in the patient's full recovery
«O que é, bebé?», ou o que a Mãe diz ao Recém-nascido no Contacto Precoce
Com o presente estudo, que se insere numa investigação
mais lata sobre padrões de comunicação precoce
mãe-criança, pretende-se descrever algumas das
características da linguagem verbal que as mães dirigem
aos seus filhos, durante o contacto-precoce e da
forma como o bebé real é, nesse momento, percepcionado
e investido pela mãe.
Para tal realizou-se o registo auditivo do contacto
precoce de 30 pares de mães-bebés. Posteriormente
analisou-se o discurso materno que foi classificado em
diversas categorias relacionadas com aspectos da estrutura
sintáctica e com análise de conteúdo.
Constatou-se que as mães recorrem pouco a expressao
verbal, no primeiro contacto com os seus filhos.
Quando o fazem utilizam uma linguagem que tem características
da «fala de bebé)) e é constituída, sobretudo,
por interjeições, exclamações, frases com duas a
três palavras e palavras isoladas. O discurso emitido
centra-se em torno da realidade vivida no momento.
O bebé que a mãe descreve é um ser pequenino e
frágil, que chora e tem fome, pouco individualizado e
pouco «humano», a quem atribui essencialmente, necessidades
fisiológicas.In the present study, part of a broader research on
mother-child early communication patterns, we
describe some of the verbal language characteristics of
mothers speaking to their children in early interactions,
and we discuss the way in wich the real baby
is, at that stage, perceived and elaborated by the mother.
The early contacts of 30 pairs mother-child were
recorded. The speech of these mothers was classified
in severa1 categories according to syntax structure and
also through content analysis. ment.
In these initial contacts, mothers don’t use much
verbal language. When they do, they use «baby talk»
expressions and emit mostly exclamations and
interjections, two or three-word sentences and isolated
words. The speech is centered in the reality of the mo-
The baby described by the mother is a small and
fragile being, who cries and feels hunger, not very
individualized and not very «human», and in whom
she recognizes, essentially, psysiological needs.info:eu-repo/semantics/publishedVersio
Loss of p53 Ser18 and Atm Results in Embryonic Lethality without Cooperation in Tumorigenesis
Phosphorylation at murine Serine 18 (human Serine 15) is a critical regulatory process for the tumor suppressor function of p53. p53Ser18 residue is a substrate for ataxia-telangiectasia mutated (ATM) and ATM-related (ATR) protein kinases. Studies of mice with a germ-line mutation that replaces Ser18 with Ala (p53S18A mice) have demonstrated that loss of phosphorylation of p53Ser18 leads to the development of tumors, including lymphomas, fibrosarcomas, leukemia and leiomyosarcomas. The predominant lymphoma is B-cell lymphoma, which is in contrast to the lymphomas observed in Atm−/− animals. This observation and the fact that multiple kinases phosphorylate p53Ser18 suggest Atm-independent tumor suppressive functions of p53Ser18. Therefore, in order to examine p53Ser18 function in relationship to ATM, we analyzed the lifespan and tumorigenesis of mice with combined mutations in p53Ser18 and Atm. Surprisingly, we observed no cooperation in survival and tumorigenesis in compound p53S18A and Atm−/− animals. However, we observed embryonic lethality in the compound mutant animals. In addition, the homozygous p53Ser18 mutant allele impacted the weight of Atm−/− animals. These studies examine the genetic interaction of p53Ser18 and Atm in vivo. Furthermore, these studies demonstrate a role of p53Ser18 in regulating embryonic survival and motor coordination
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