Constructing near-horizon geometries in supergravities with hidden symmetry

We consider the classification of near-horizon geometries in a general two-derivative theory of gravity coupled to abelian gauge fields and uncharged scalars in four and five dimensions, with one and two commuting rotational symmetries respectively. Assuming that the theory of gravity reduces to a 3d non-linear sigma model (as is typically the case for ungauged supergravities), we show that the functional form of any such near-horizon geometry may be determined. As an example we apply this to five dimensional minimal supergravity. We also construct an example of a five parameter near-horizon geometry solution to this theory with S^1 X S^2 horizon topology. We discuss its relation to the near-horizon geometries of the yet to be constructed extremal black rings with both electric and dipole charges.Comment: Latex, 30 pages. v2: discussion in section 5 modified and improved, other minor changes, references adde

A general dissipativity constraint for feedback system design, with emphasis on MPC

A ‘General Dissipativity Constraint’ (GDC) is introduced to facilitate the design of stable feedback systems. A primary application is to MPC controllers when it is preferred to avoid the use of ‘stabilising ingredients’ such as terminal constraint sets or long prediction horizons. Some very general convergence results are proved under mild conditions. The use of quadratic functions, replacing GDC by ‘Quadratic Dissipation Constraint’ (QDC), is introduced to allow implementation using linear matrix inequalities. The use of QDC is illustrated for several scenarios: state feedback for a linear time-invariant system, MPC of a linear system, MPC of an input-affine system, and MPC with persistent disturbances. The stability that is guaranteed by GDC is weaker than Lyapunov stability, being ‘Lagrange stability plus convergence’. Input-to-state stability is obtained if the control law is continuous in the state. An example involving an open-loop unstable helicopter illustrates the efficacy of the approach in practice.National Research Foundation Singapor

Factors Affecting Retention of Undergraduate Students in Fisheries and Wildlife Programs

Undergraduate enrollment in agriculture and natural resources‐related programs has steadily declined for the past decade or more. College administrators and faculty struggle to separate the real causes of this decline from the superficial and often mythical factors. How programs should address this decline is of similar concern. Rather than speculate on why students do not pursue a degree in a natural resources field, specifically fisheries and wildlife (FW), we decided to investigate the question of FW student retention from the perspective of the students themselves. Specifically, we wanted to know: (a) Why do students say they chose to leave the FW program at MSU? (b) Why did students who persisted in program say they chose to stay? and (c) What reasons did transfer students give for choosing FW as a major? We conducted a series of face‐to‐face interviews with these three groups of students, and asked them a series of 10‐14 questions related to their experiences in the Department of Fisheries and Wildlife at Michigan State University in an effort to better understand student reasons for leaving, persisting, and immigrating into the program. Although our project is just beginning, preliminary results offer some interesting insights into the departure puzzle. Specific, but limited, findings from interviewees include: (a) the importance of job prospects and earnings potential, (b) a general reluctance to pursue postgraduate education, (c) a degree of disillusionment at the relative lack of outdoor experiences offered by the program in classroom and extracurricular activities, and (d) a desire for more active participation and field experiences in the undergraduate program. Several students in this study told us that they selected FW out of a desire to spend more time in the field, and were disappointed this was frequently not the case. Some students expressed a general feeling of deception at the realities of the departmental curriculum, although these were poorly defined and may be the product of other issues such as unrealistic program expectations. This ongoing study has the potential to inform natural resource programs on techniques to attract, retain, and educate undergraduate students

An international comparative study of blood pressure in populations of European vs. African descent

Background: The consistent finding of higher prevalence of hypertension in US blacks compared to whites has led to speculation that African-origin populations are particularly susceptible to this condition. Large surveys now provide new information on this issue. Methods: Using a standardized analysis strategy we examined prevalence estimates for 8 white and 3 black populations (N = 85,000 participants). Results: The range in hypertension prevalence was from 27 to 55% for whites and 14 to 44% for blacks. Conclusions: These data demonstrate that not only is there a wide variation in hypertension prevalence among both racial groups, the rates among blacks are not unusually high when viewed internationally. These data suggest that the impact of environmental factors among both populations may have been under-appreciated

Supersymmetric black hole non-uniqueness in five dimensions

We present a systematic study of the moduli space of asymptotically flat, supersymmetric and biaxisymmetric black hole solutions to five-dimensional minimal supergravity. Previously, it has been shown that such solutions must be multi-centred solutions with a Gibbons-Hawking base. In this paper we perform a full analysis of three-centred solutions with a single black hole, for which there are seven regular black hole solutions. We find that four of these can have the same conserved charges as the BMPV black hole. These consist of a black lens with L(3,1) horizon topology and three distinct families of spherical black holes with nontrivial topology outside the horizon. The former provides the first example of a nonspherical black hole with the same conserved charges as the BMPV black hole. Moreover, of these four solutions, three can have a greater entropy than the BMPV black hole near the BMPV upper spin bound. One of these is a previously known spherical black hole with nontrivial topology and the other two are new examples of a spherical black hole with nontrivial topology and an L(3,1) black lens.Comment: version 2: typos corrected, minor clarifications added; 26 pages, 10 figure

Characterization of renal cell carcinoma-associated constitutional chromosome abnormalities by genome sequencing.

Constitutional translocations, typically involving chromosome 3, have been recognized as a rare cause of inherited predisposition to renal cell carcinoma (RCC) for four decades. However, knowledge of the molecular basis of this association is limited. We have characterized the breakpoints by genome sequencing (GS) of constitutional chromosome abnormalities in five individuals who presented with RCC. In one individual with constitutional t(10;17)(q11.21;p11.2), the translocation breakpoint disrupted two genes: the known renal tumor suppressor gene (TSG) FLCN (and clinical features of Birt-Hogg-Dubé syndrome were detected) and RASGEF1A. In four cases, the rearrangement breakpoints did not disrupt known inherited RCC genes. In the second case without chromosome 3 involvement, the translocation breakpoint in an individual with a constitutional t(2;17)(q21.1;q11.2) mapped 12 Kb upstream of NLK. Interestingly, NLK has been reported to interact indirectly with FBXW7 and a previously reported RCC-associated translocation breakpoint disrupted FBXW7. In two cases of constitutional chromosome 3 translocations, no candidate TSGs were identified in the vicinity of the breakpoints. However, in an individual with a constitutional chromosome 3 inversion, the 3p breakpoint disrupted the FHIT TSG (which has been reported previously to be disrupted in two apparently unrelated families with an RCC-associated t(3;8)(p14.2;q24.1). These findings (a) expand the range of constitutional chromosome rearrangements that may be associated with predisposition to RCC, (b) confirm that chromosome rearrangements not involving chromosome 3 can predispose to RCC, (c) suggest that a variety of molecular mechanisms are involved the pathogenesis of translocation-associated RCC, and (d) demonstrate the utility of GS for investigating such cases

Simulations of extensional flow in microrheometric devices

We present a detailed numerical study of the flow of a Newtonian fluid through microrheometric devices featuring a sudden contraction–expansion. This flow configuration is typically used to generate extensional deformations and high strain rates. The excess pressure drop resulting from the converging and diverging flow is an important dynamic measure to quantify if the device is intended to be used as a microfluidic extensional rheometer. To explore this idea, we examine the effect of the contraction length, aspect ratio and Reynolds number on the flow kinematics and resulting pressure field. Analysis of the computed velocity and pressure fields show that, for typical experimental conditions used in microfluidic devices, the steady flow is highly three-dimensional with open spiraling vortical structures in the stagnant corner regions. The numerical simulations of the local kinematics and global pressure drop are in good agreement with experimental results. The device aspect ratio is shown to have a strong impact on the flow and consequently on the excess pressure drop, which is quantified in terms of the dimensionless Couette and Bagley correction factors. We suggest an approach for calculating the Bagley correction which may be especially appropriate for planar microchannels

A systematic review of strategies to recruit and retain primary care doctors

Background There is a workforce crisis in primary care. Previous research has looked at the reasons underlying recruitment and retention problems, but little research has looked at what works to improve recruitment and retention. The aim of this systematic review is to evaluate interventions and strategies used to recruit and retain primary care doctors internationally. Methods A systematic review was undertaken. MEDLINE, EMBASE, CENTRAL and grey literature were searched from inception to January 2015.Articles assessing interventions aimed at recruiting or retaining doctors in high income countries, applicable to primary care doctors were included. No restrictions on language or year of publication. The first author screened all titles and abstracts and a second author screened 20%. Data extraction was carried out by one author and checked by a second. Meta-analysis was not possible due to heterogeneity. Results 51 studies assessing 42 interventions were retrieved. Interventions were categorised into thirteen groups: financial incentives (n=11), recruiting rural students (n=6), international recruitment (n=4), rural or primary care focused undergraduate placements (n=3), rural or underserved postgraduate training (n=3), well-being or peer support initiatives (n=3), marketing (n=2), mixed interventions (n=5), support for professional development or research (n=5), retainer schemes (n=4), re-entry schemes (n=1), specialised recruiters or case managers (n=2) and delayed partnerships (n=2). Studies were of low methodological quality with no RCTs and only 15 studies with a comparison group. Weak evidence supported the use of postgraduate placements in underserved areas, undergraduate rural placements and recruiting students to medical school from rural areas. There was mixed evidence about financial incentives. A marketing campaign was associated with lower recruitment. Conclusions This is the first systematic review of interventions to improve recruitment and retention of primary care doctors. Although the evidence base for recruiting and care doctors is weak and more high quality research is needed, this review found evidence to support undergraduate and postgraduate placements in underserved areas, and selective recruitment of medical students. Other initiatives covered may have potential to improve recruitment and retention of primary care practitioners, but their effectiveness has not been established