Theoretical study on the ionization of aniline in aqueous solutions

The ionization and excitation processes of aniline in aqueous solutions are investigated by the method of RISM-SCF-SEDD (reference interaction site model self-consistent field with the spatial electron density distribution). Four different models are employed to characterize the response of the solvation upon the ionization and excitation. A simple treatment for estimation of the spectral width is also proposed

Hunter-Gatherer Mortuary Variability in Vietnam

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<臨床>胃癌術後に肺転移巣を切除した2例

It is said that the prognosis is poor in cases with recurrent pulmonary metastasis after operation for gastric cancer. In this article, 2 cases with nodular type of pulmonary metastasis resected after operation for gastric cancer and surviving well are reported by the authors. Case 1: 57year-old female. The patient underwent a total gastrectomy for the 3'type of cardiac cancer. As the serum levels of tumor markers increased and the chest X-ray examination revealed a mass lesion in the right lung (S_10), the operation for the lesion under the diagnosis of metastatic lung cancer was performed 1 year and 2 months after gastrectomy. The patient died of pulmonal and pleural metastasis 4 years and 7 months after the first operation. Case 2: 65-year-old male. The patient underwent a subtotal gastrectomy for the 5'type of gastric cancer. Chest X-ray examination for follow-up study revealed a mass lesion in the left lung (S_5). The patient underwent a left pulmonary superior lobe resection 2 years and 9 months after gastrectomy. The patient is still alive 6 years after the first operation. Surgical treatment must be actively considered for nodular type of metastatic lung cancer after operation for gastric cancer.胃癌術後に肺転移をきたした症例の予後は不良とされている. 今回, 胃切除術後に結節型肺転移巣を切除し, 良好な結果を得た胃癌の2例を経験したので、報告する. 症例 1 は57歳, 女性. 噴門部 2'型胃癌の診断のもと, 胃全摘術を受けている. 腫瘍マーカーの上昇があり, 胸部X線写真で右肺 S_10 に腫瘤陰影を認めた. 胃癌術後1年2カ月目に肺部分切除術を施行した. 患者は胃癌切除後4年7カ月で肺転移および癌性胸膜炎のため死亡した. 症例2は65歳, 男性. 胃体部 5'型胃癌の診断のもと, 胃亜全摘を受けている. 術後経過観察中, 胸部X線写真で左肺 S_5 に腫瘤陰影を認め, 胃癌術後2年9カ月目に左肺上葉切除切除術を施行した. 患者は胃癌切除術後6年で健在である. 結節型の肺転移例に対しては積極的な外科手術を考慮すべきである

Differencial Diagnosis of an Abdominal Tumors of Uncertain Origin Using Fine Needle Aspiration Biopsy (FNAB)

FNAB under ultrasonic guidance was performed on 14 cases with abdomical tumors of uncertain origin. All of them could not be clarified their relationship with the liver, the biliary tract, the pancreas or the alimentary tract by routine clinical exams including diagnostic imaging such as CT and Ultrasonography. Preoperating histological diagnosis has been obtained for 12 of these by FNAB, thus diagnostic rate being 85.7%. The details of tumors identified by autopsy and operations were: 3 cases of lymphoma; 3 cases of leiomyosarcoma; 4 cases of adenocarcinoma; 2 cases of hematoma; and 1 case of inflammatory mass. Non-epithelial tumor was most frequently observed. FNAB is a simple diagnostic method with high cost-effectiveness for determining the therapeutical plan for an abdominal tumor of uncertain origin which is encounted in the daily treatment

Health and the Experience of Childhood in Late Neolithic Vietnam

The article aims to examine aspects of mortuary behavior in late Neolithic/early Bronze Age (Phung Nguyen phase) populations represented at the site of Man Bac in Viet Nam, specifically how mortuary behavior illuminates the role of children, and adult attitudes toward children. In addition, the authors discuss biological characteristics of the human sample, focusing particularly on the child burials, in order to explore aspects of childhood palaeohealth. The methodology includes combining various measures of health-including palaeodemography (childhood mortality), analysis of oral health (Early Childhood Caries or ECC), and analysis of physiological health (Cribra Orbitalia and LEH)-with studies of culturally defined mortuary practices to suggest that, while children clearly had significant health deficiencies and many suffered early deaths, their treatment in mortuary rites shows significant economic value and social esteem placed on children. KEYWORDS: Viet Nam, Neolithic, childhood, health, mortuary behavior, palaeodemography, bioarchaeology

Serotonin enhances the production of type IV collagen by human mesangial cells

Serotonin enhances the production of type IV collagen by human mesangial cells.BackgroundThe plasma concentration of 5-hydroxytryptamine (5-HT) in diabetic patients is higher than that in normal subjects. Since recent reports have demonstrated the presence of 5-HT2A receptor in glomerular mesangial cells, it is possible that 5-HT may be involved in the development of diabetic nephropathy through the 5-HT2A receptor in mesangial cells. Because expansion of the glomerular mesangial lesion is a characteristic feature of diabetic nephropathy, we examined the effect of 5-HT on the production of type IV collagen by human mesangial cells.MethodsHuman mesangial cells were incubated with 5-HT with or without 5-HT receptor antagonists, protein kinase C (PKC) inhibitor or transforming growth factor-β (TGF-β) antibody. Type IV collagen mRNA and protein concentration in medium were measured by Northern blot analysis and enzyme-linked immunosorbent assay (ELISA), respectively. TGF-β mRNA and bioactivity in the medium were measured by Northern blot analysis and bioassay using mink lung epithelial cells, respectively.Results5-HT stimulated the production of type IV collagen by human mesangial cells, which was inhibited by ketanserin and sarpogrelate hydrochloride, 5-HT2A receptor antagonists, but not by ondansetron, a 5-HT3 receptor antagonist. 5-HT increased the bioactivities of both active and total TGF-β. However, the 5-HT-enhanced production of type IV collagen was completely inhibited by an anti-TGF-β antibody. Furthermore, a PKC inhibitor, calphostin C, inhibited the 5-HT-induced increase in type IV collagen secretion, and the activity of membrane PKC was increased by 5-HT. Phorbol ester activated type IV collagen production as well as active and total TGF-β. Calphostin C completely inhibited the 5-HT-enhanced activity of active TGF-β, but did not inhibit exogenous TGF-β-induced increase in type IV collagen secretion.ConclusionsOur results suggest that 5-HT-enhanced production of type IV collagen by human mesangial cells is mediated by activation of PKC and subsequent increase in active TGF-β activity

Identity and community structure in Neolithic Man Bac, Northern Vietnam

FUNDING This research was supported by JSPS fund 16H02527 and Australian Research Council grant DP0774079. ACKNOWLEDGEMENTS Many people have been involved in the excavation and post-excavation work associated with Man Bac over the years. Here we wish to pay special thanks to Nguyen Kim Dung (then of the Institute of Archaeology, Hanoi) who co-directed the excavations in 2004/5 and 2007. The following were involved in either one or several ways between 2004/5 and 2007 (facilitation of land access, excavation, post-excavation analysis, and ublication): Nguyen Hann Khang and Nguyen Cao Tan (Ninh Binh Provincial Museum, Vietnam), the landowner of Man Bac Nguyen Van Sai, the Chung Village community, Peter Bellwood and Lorna Tilley (Australian National University), Nguyen Giang Hai (former Director, Institute of Archaeology, Hanoi), Nguyen Kim Thuy, Nguyen An Tuan, Vu The Long, Tran Thi Thuy Ha, Bui Thu Phuong, Ha Manh Thang, Nguyen Ngoc Quy, Vo Thanh Huong, Nguyen Chi Tan, Nguyen Thi Mai Huong (Institute of Archaeology, Hanoi), Mariko Yamagata (Okayama Science University, Japan), Ken-ichi Shidoda (National Museum of Nature and Science, Japan), Yukio Dodo (formerly of Tohoku University, Japan), Takeji Toizumi (Meiji University, Japan), Junmei Sawada (Nigata University of Health and Welfare, Japan), Mark Lipson (Harvard Medical School, USA), Anna Willis (James Cook University, Australia). Many thanks to Jeff Oliver for reading and commenting on an earlier draft.Peer reviewedPostprin

Paleoepidemiology of cribra orbitalia : Insights from early seventh millennium BP Con Co Ngua, Vietnam

Funding Information: Grant sponsors: Australian Research Council DP110101097, FT120100299. Publisher Copyright: © 2023 The Authors. American Journal of Biological Anthropology published by Wiley Periodicals LLC.Peer reviewedPublisher PD

Domestication and large animal interactions : Skeletal trauma in northern Vietnam during the hunter-gatherer Da but period

Funding: Grant sponsors were: Australian Research Council DP110101097; FT 120100299 awarded to MO; Institute of Advanced Study (IAS), Durham University and the COFUND 'Durham International Fellowships for Research and Enterprise' scheme. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Peer reviewedPublisher PD