Inhibition of pancreatic cholesterol esterase reduces cholesterol absorption in the hamster

BACKGROUND: Pancreatic cholesterol esterase has three proposed functions in the intestine: 1) to control the bioavailability of cholesterol from dietary cholesterol esters; 2) to contribute to incorporation of cholesterol into mixed micelles; and 3) to aid in transport of free cholesterol to the enterocyte. Inhibitors of cholesterol esterase are anticipated to limit the absorption of dietary cholesterol. RESULTS: The selective and potent cholesterol esterase inhibitor 6-chloro-3-(1-ethyl-2-cyclohexyl)-2-pyrone (figure 1, structure 1) was administered to hamsters fed a high cholesterol diet supplemented with radiolabeled cholesterol ester. Hamsters were gavage fed (3)H-labeled cholesteryl oleate along with inhibitor 1, 0–200 micromoles. Twenty-four hours later, hepatic and serum radioactive cholesterol levels were determined. The ED(50 )of inhibitor 1 for prevention of the uptake of labeled cholesterol derived from hydrolysis of labeled cholesteryl oleate was 100 micromoles. The toxicity of inhibitor 1 was investigated in a 30 day feeding trial. Inhibitor 1, 100 micromoles or 200 micromoles per day, was added to chow supplemented with 1% cholesterol and 0.5% cholic acid. Clinical chemistry urinalysis and tissue histopathology were obtained. No toxicity differences were noted between control and inhibitor supplemented groups. CONCLUSIONS: Inhibitors of cholesterol esterase may be useful therapeutics for limiting cholesterol absorption

Magnon Heat Transport in doped La2CuO4\rm La_2CuO_4

We present results of the thermal conductivity of $\rm La_2CuO_4$ and $\rm La_{1.8}Eu_{0.2}CuO_4$ single-crystals which represent model systems for the two-dimensional spin-1/2 Heisenberg antiferromagnet on a square lattice. We find large anisotropies of the thermal conductivity, which are explained in terms of two-dimensional heat conduction by magnons within the CuO$_2$ planes. Non-magnetic Zn substituted for Cu gradually suppresses this magnon thermal conductivity $\kappa_{\mathrm{mag}}$. A semiclassical analysis of $\kappa_{\mathrm{mag}}$ is shown to yield a magnon mean free path which scales linearly with the reciprocal concentration of Zn-ions.Comment: 4 pages, 3 figure

Expansion velocity of a one-dimensional, two-component Fermi gas during the sudden expansion in the ballistic regime

We show that in the sudden expansion of a spin-balanced two-component Fermi gas into an empty optical lattice induced by releasing particles from a trap, over a wide parameter regime, the radius $R_n$ of the particle cloud grows linearly in time. This allow us to define the expansion velocity $V_{ex}$ from $R_n=V_{ex}t$. The goal of this work is to clarify the dependence of the expansion velocity on the initial conditions which we establish from time-dependent density matrix renormalization group simulations, both for a box trap and a harmonic trap. As a prominent result, the presence of a Mott-insulating region leaves clear fingerprints in the expansion velocity. Our predictions can be verified in experiments with ultra-cold atoms.Comment: 8 pages 10 figures, version as published with minor stylistic change

Long-time behavior of the momentum distribution during the sudden expansion of a spin-imbalanced Fermi gas in one dimension

We study the sudden expansion of spin-imbalanced ultracold lattice fermions with attractive interactions in one dimension after turning off the longitudinal confining potential. We show that the momentum distribution functions of majority and minority fermions approach stationary values quickly due to a quantum distillation mechanism that results in a spatial separation of pairs and majority fermions. As a consequence, Fulde-Ferrell-Larkin-Ovchinnikov (FFLO) correlations are lost during the expansion. Furthermore, we argue that the shape of the stationary momentum distribution functions can be understood by relating them to the integrals of motion in this integrable quantum system. We discuss our results in the context of proposals to observe FFLO correlations, related to recent experiments by Liao et al., Nature 467, 567 (2010).Comment: 8 pages including supplementary material, 9 eps figures, revised version as published, some text moved to the supplemental materia

Thermomagnetic Power and Figure of Merit for Spin-1/2 Heisenberg Chain

Transport properties in the presence of magnetic fields are numerically studied for the spin-1/2 Heisenberg XXZ chain. The breakdown of the spin-reversal symmetry due to the magnetic field induces the magnetothermal effect. In analogy with the thermoelectric effect in electron systems, the thermomagnetic power (magnetic Seebeck coefficient) is provided, and is numerically evaluated by the exact diagonalization for wide ranges of temperatures and various magnetic fields. For the antiferromagnetic regime, we find the magnetic Seebeck coefficient changes sign at certain temperatures, which is interpreted as an effect of strong correlations. We also compute the thermomagnetic figure of merit determining the efficiency of the thermomagnetic devices for cooling or power generation.Comment: 8 page

Sudden expansion of Mott insulators in one dimension

We investigate the expansion of bosons and fermions in a homogeneous lattice after a sudden removal of the trapping potential using exact numerical methods. As a main result, we show that in one dimension, both bosonic and fermionic Mott insulators expand with the same velocity, irrespective of the interaction strength, provided the expansion starts from the ground state of the trapped gas. Furthermore, their density profiles become identical during the expansion; the asymptotic density dynamics is identical to that of initially localized, noninteracting particles, and the asymptotic velocity distribution is flat. The expansion velocity for initial correlated Mott insulating states is therefore independent of the interaction strength and particle statistics. Interestingly, this nonequilibrium dynamics is sensitive to the interaction driven quantum phase transition in the Bose-Hubbard model; while being constant in the Mott phase, the expansion velocity decreases in the superfluid phase and vanishes for large systems in the noninteracting limit. These results are compared to the setup of a recent experiment [Ronzheimer et al., Phys. Rev. Lett. 110, 205301 (2013)], where the trap opening was combined with an interaction quench from infinitely strong interactions to finite values. In the latter case, the interaction quench breaks the universal dynamics in the asymptotic regime and the expansion depends on the interaction strength. We carry out an analogous analysis for a two-component Fermi gas, with similar observations. In addition, we study the effect of breaking the integrability of hard-core bosons in different ways; while the fast ballistic expansion from the ground state of Mott insulators in one dimension remains unchanged for finite interactions, we observe strong deviations from this behavior on a two-leg ladder even in the hard-core case. This change in dynamics bares similarities with the dynamics in the dimensional crossover from one to two dimensions observed in the aformentioned experimental study

On calculation of vector spin chirality for zigzag spin chains

We calculate the vector spin chirality for $S=1/2$ zigzag spin chains having U(1) symmetry, using the density matrix renormalization group combined with unitary transformation. We then demonstrate the occurrence of the chiral order for the zigzag XY chain and discuss the associated phase transition. The results are consistent with the analysis based on the bosonization and the long distance behaviour of the chirality correlation function. For the $S=1/2$ zigzag Heisenberg chain in a magnetic field, we also verify the chiral order that is predicted by the effective field theory and the chirality correlation function, and then determine its magnetic phase diagram.Comment: 7 pages, 9 figures, accepted for publication in J. Phys. Soc. Jp

Asymmetric Heat Flow in Mesoscopic Magnetic System

The characteristics of heat flow in a coupled magnetic system are studied. The coupled system is composed of a gapped chain and a gapless chain. The system size is assumed to be quite small so that the mean free path is comparable to it. When the parameter set of the temperatures of reservoirs is exchanged, the characteristics of heat flow are studied with the Keldysh Green function technique. The asymmetry of current is found in the presence of a local equilibrium process at the contact between the magnetic systems. The present setup is realistic and such an effect will be observed in real experiments. We also discuss the simple phenomenological explanation to obtain the asymmetry.Comment: 13 pages, 3 figure

Time evolution of 1D gapless models from a domain-wall initial state: SLE continued?

We study the time evolution of quantum one-dimensional gapless systems evolving from initial states with a domain-wall. We generalize the path-integral imaginary time approach that together with boundary conformal field theory allows to derive the time and space dependence of general correlation functions. The latter are explicitly obtained for the Ising universality class, and the typical behavior of one- and two-point functions is derived for the general case. Possible connections with the stochastic Loewner evolution are discussed and explicit results for one-point time dependent averages are obtained for generic \kappa for boundary conditions corresponding to SLE. We use this set of results to predict the time evolution of the entanglement entropy and obtain the universal constant shift due to the presence of a domain wall in the initial state.Comment: 27 pages, 10 figure

The embedding method beyond the single-channel case: Two-mode and Hubbard chains

We investigate the relationship between persistent currents in multi-channel rings containing an embedded scatterer and the conductance through the same scatterer attached to leads. The case of two uncoupled channels corresponds to a Hubbard chain, for which the one-dimensional embedding method is readily generalized. Various tests are carried out to validate this new procedure, and the conductance of short one-dimensional Hubbard chains attached to perfect leads is computed for different system sizes and interaction strengths. In the case of two coupled channels the conductance can be obtained from a statistical analysis of the persistent current or by reducing the multi-channel scattering problem to several single-channel setups.Comment: 14 pages, 13 figures, submitted for publicatio