24-hour sodium and potassium excretion in the Americas: a systematic review and meta-analysis.

OBJECTIVE: To determine the 24-hour urinary sodium and potassium excretions in the Americas. METHODS: A systematic review and meta-analysis were performed seeking for studies conducted between 1990 and 2021 in adults living in any sovereign state of the Americas in Medline, Embase, Scopus, SciELO, and Lilacs. The search was first run on October 26th, 2020 and was updated on December 15th, 2021. Of 3 941 abstracts reviewed, 74 studies were included from 14 countries, 72 studies reporting urinary sodium (27 387 adults), and 42 studies reporting urinary potassium (19 610 adults) carried out between 1990 and 2020. Data were pooled using a random-effects meta-analysis model. RESULTS: Mean excretion was 157.29 mmol/24h (95% CI, 151.42-163.16) for sodium and 57.69 mmol/24h (95% CI, 53.35-62.03) for potassium. When only women were considered, mean excretion was 135.81 mmol/24h (95% CI, 130.37-141.25) for sodium and 51.73 mmol/24h (95% CI, 48.77-54.70) for potassium. In men, mean excretion was 169.39 mmol/24h (95% CI, 162.14-176.64) for sodium and 62.67 mmol/24h (95% CI, 55.41-69.93) for potassium. Mean sodium excretion was 150.09 mmol/24h (95% CI, 137.87-162.30) in the 1990s and 159.79 mmol/24h (95% CI, 151.63-167.95) in the 2010s. Mean potassium excretion was 58.64 mmol/24h (95% CI, 52.73-64.55) in the 1990s and 56.33 mmol/24/h (95% CI, 48.65-64.00) in the 2010s. CONCLUSIONS: These findings suggest that sodium excretions are almost double the maximum level recommended by the World Health Organization and potassium excretions are 35% lower than the minimum requirement; therefore, major efforts to reduce sodium and to increase potassium intakes should be implemented

Top-quark couplings to TeV resonances at future lepton colliders

We study the processes $W_L W_L \to t \bar t$ and $W_L Z_L \to t\bar b (\bar t b)$ at future lepton colliders as probes of the couplings of the top quark to resonances at the TeV scale. We consider the cases in which the dominant low energy feature of a strongly interacting electroweak symmetry breaking sector is either a scalar or a vector resonance with mass near 1 TeV. We find that future lepton colliders with high energy and high luminosity have great potential to sensitively probe these physics scenarios. In particular, at a 1.5 TeV linear collider with an integrated luminosity of 200 fb$^{-1}$, we expect about 120 events for either a scalar or a vector to decay to $t\bar t, t \bar b$. Their leading partial decay widths, which characterize the coupling strengths, can be statistically determined to about 10% level.Comment: 33 pages, 9 ps figures, 1 tabl

Important discoveries from analysing bacterial phenotypes

The ability to test hundreds to thousands of cellular phenotypes in a single experiment has opened up new avenues of investigation and exploration and led to important discoveries in very diverse applications of microbiological research and development. The information provided by global phenotyping is complementary to, and often more easily interpretable than information provided by global molecular analytical methods such as gene chips and proteomics. This report summarizes advances presented by scientists brought together to share their experiences and knowledge gained with high-throughput phenotyping

LHC sensitivity to the resonance spectrum of a minimal strongly interacting electroweak symmetry breaking sector

We present a unified analysis of the two main production processes of vector boson pairs at the LHC, VV-fusion and qqbar annihilation, in a minimal strongly interacting electroweak symmetry breaking sector. Using a unitarized electroweak chiral Lagrangian formalism and modeling the final V_L V_L strong rescattering effects by a form factor, we describe qqbar annihilation processes in terms of the two chiral parameters that govern elastic V_L V_L scattering. Depending on the values of these two chiral parameters, the unitarized amplitudes may present resonant enhancements in different angular momentum-isospin channels. Scanning this two parameter space, we generate the general resonance spectrum of a minimal strongly interacting electroweak symmetry breaking sector and determine the regions that can be probed at the LHC.Comment: Final version to appear in Phys. Rev. D, including a more detailed exposition and a few more references. Conclusions and results unchanged. 14 pages, 5 figure

Radial Growth of Qilian Juniper on the Northeast Tibetan Plateau and Potential Climate Associations

There is controversy regarding the limiting climatic factor for tree radial growth at the alpine treeline on the northeastern Tibetan Plateau. In this study, we collected 594 increment cores from 331 trees, grouped within four altitude belts spanning the range 3550 to 4020 m.a.s.l. on a single hillside. We have developed four equivalent ring-width chronologies and shown that there are no significant differences in their growth-climate responses during 1956 to 2011 or in their longer-term growth patterns during the period AD 1110–2011. The main climate influence on radial growth is shown to be precipitation variability. Missing ring analysis shows that tree radial growth at the uppermost treeline location is more sensitive to climate variation than that at other elevations, and poor tree radial growth is particularly linked to the occurrence of serious drought events. Hence water limitation, rather than temperature stress, plays the pivotal role in controlling the radial growth of Sabina przewalskii Kom. at the treeline in this region. This finding contradicts any generalisation that tree-ring chronologies from high-elevation treeline environments are mostly indicators of temperature changes

GPIHBP1 expression in gliomas promotes utilization of lipoprotein-derived nutrients

GPIHBP1, a GPI-anchored protein of capillary endothelial cells, binds lipoprotein lipase (LPL) within the subendothelial spaces and shuttles it to the capillary lumen. The GPIHBP1-bound LPL is essential for the margination of triglyceride-rich lipoproteins (TRLs) along capillaries, allowing the lipolytic processing of TRLs to proceed. In peripheral tissues, the intravascular processing of TRLs by the GPIHBP1-LPL complex is crucial for generating lipid nutrients for adjacent parenchymal cells. GPIHBP1 is absent in capillaries of the brain, which uses glucose for fuel; however, GPIHBP1 is expressed in capillaries of mouse and human gliomas. Importantly, the GPIHBP1 in glioma capillaries captures locally produced LPL. We document, by NanoSIMS imaging, that TRLs marginate along glioma capillaries and that there is uptake of TRL-derived lipid nutrients by surrounding glioma cells. Thus, GPIHBP1 expression in gliomas facilitates TRL processing and provides a source of lipid nutrients for glioma cells