GE Jet Engine Bracket Challenge: A Case Study in Sustainable Design

Open crowdsourcing competitions can provide a large repository of data which can be used to achieve more sustainable product designs. This study looks at the recent General Electric challenge, a competition to minimize the mass of a titanium jet engine lifting bracket, to illustrate the benefits that can be accrued. In the light of current literature the benefits and challenges of crowdsourcing have been considered. Samples of the entrants to the challenge have been compared to identify critical characteristics for interpreting sustainable designs for additive manufacture. Focusing initially on topological optimisation and orientation of the additive manufacture build, critical features have been highlighted. The availability of many CAD designs has been most useful and has potential for future developments. Crowdsourcing as an innovation approach can also be beneficial for both companies and individuals particularly if the entries are open source

Ammonia scavenging agents for people with cirrhosis and hepatic encephalopathy

This is the protocol for a review and there is no abstract. The objectives are as follows: To evaluate the benefits and harms of ammonia scavenging agents versus placebo, no intervention, or other active interventions for people with cirrhosis and hepatic encephalopathy

GE Jet Engine Bracket Challenge: A Case Study in Sustainable Design

Open crowdsourcing competitions can provide a large repository of data which can be used to achieve more sustainable product designs. This study looks at the recent General Electric challenge, a competition to minimize the mass of a titanium jet engine lifting bracket, to illustrate the benefits that can be accrued. In the light of current literature the benefits and challenges of crowdsourcing have been considered. Samples of the entrants to the challenge have been compared to identify critical characteristics for interpreting sustainable designs for additive manufacture. Focusing initially on topological optimisation and orientation of the additive manufacture build, critical features have been highlighted. The availability of many CAD designs has been most useful and has potential for future developments. Crowdsourcing as an innovation approach can also be beneficial for both companies and individuals particularly if the entries are open sourc

Computational Methodology for Optimal Design of Additive Layer Manufactured Turbine Bracket

The design of critical components for aircrafts, cars or any other kind of machinery today is typically subject to two conflicting objectives, namely the maximisation of strength and the minimisation of weight. The conflicting nature of these two objectives makes it impossible to obtain a design that is optimal for both. The most common approach aiming for a single objective optimisation problem in aerospace is to maintain the weight minimisation as the objective, whilst setting strength requirements as constraints to be satisfied. However, manufacturing methods incorporate additional restrictions for an optimal design to be considered feasible, even when satisfying all constraints in the formulation of the optimisation problem. In this context, Additive Layer Manufacturing adds remarkably higher flexibility to the manufacturability of shape designs when compared with traditional processes. It is fair to note, however, that there are still some restrictions such as the infeasibility of building unsupported layers forming angles smaller than 45 degrees with respect to the underlying one. Nowadays, it is common practice to use a set of software tools to deal with these kinds of problems, namely Computer Aided Design (CAD), Finite Element Analysis (FEA), and optimisation packages. The adequate use of these tools results in an increase in efficiency and quality of the final product. In this paper, a case study was undertaken consisting of a turbine bracket from a General Electric challenge. A computational methodology is used, which consists of a topology optimisation considering an isotropic material at first instance, followed by the manual refinement of the resulting shape taking into account the manufacturability requirements. To this end, we used SolidWorks®2013 for the CAD, Ansys Workbench®14.0 for the FEA, and HyperWorks®11 for the topology optimisation. A future methodology will incorporate the automation of the shape optimisation stage, and perhaps the inclusion of the manufacturability restriction within the optimisation formulation

The Summer 2019-2020 Wildfires in East Coast Australia and Their Impacts on Air Quality and Health in New South Wales, Australia.

The 2019–2020 summer wildfire event on the east coast of Australia was a series of major wildfires occurring from November 2019 to end of January 2020 across the states of Queensland, New South Wales (NSW), Victoria and South Australia. The wildfires were unprecedent in scope and the extensive character of the wildfires caused smoke pollutants to be transported not only to New Zealand, but also across the Pacific Ocean to South America. At the peak of the wildfires, smoke plumes were injected into the stratosphere at a height of up to 25 km and hence transported across the globe. The meteorological and air quality Weather Research and Forecasting with Chemistry (WRF-Chem) model is used together with the air quality monitoring data collected during the bushfire period and remote sensing data from the Moderate Resolution Imaging Spectroradiometer (MODIS) and Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observation (CALIPSO) satellites to determine the extent of the wildfires, the pollutant transport and their impacts on air quality and health of the exposed population in NSW. The results showed that the WRF-Chem model using Fire Emission Inventory (FINN) from National Center for Atmospheric Research (NCAR) to simulate the dispersion and transport of pollutants from wildfires predicted the daily concentration of PM2.5 having the correlation (R2) and index of agreement (IOA) from 0.6 to 0.75 and 0.61 to 0.86, respectively, when compared with the ground-based data. The impact on health endpoints such as mortality and respiratory and cardiovascular diseases hospitalizations across the modelling domain was then estimated. The estimated health impact on each of the Australian Bureau of Statistics (ABS) census districts (SA4) of New South Wales was calculated based on epidemiological assumptions of the impact function and incidence rate data from the 2016 ABS and NSW Department of Health statistical health records. Summing up all SA4 census district results over NSW, we estimated that there were 247 (CI: 89, 409) premature deaths, 437 (CI: 81, 984) cardiovascular diseases hospitalizations and 1535 (CI: 493, 2087) respiratory diseases hospitalizations in NSW over the period from 1 November 2019 to 8 January 2020. The results are comparable with a previous study based only on observation data, but the results in this study provide much more spatially and temporally detailed data with regard to the health impact from the summer 2019–2020 wildfire

Extensive sequence-influenced DNA methylation polymorphism in the human genome

Background: Epigenetic polymorphisms are a potential source of human diversity, but their frequency and relationship to genetic polymorphisms are unclear. DNA methylation, an epigenetic mark that is a covalent modification of the DNA itself, plays an important role in the regulation of gene expression. Most studies of DNA methylation in mammalian cells have focused on CpG methylation present in CpG islands (areas of concentrated CpGs often found near promoters), but there are also interesting patterns of CpG methylation found outside of CpG islands. Results: We compared DNA methylation patterns on both alleles between many pairs (and larger groups) of related and unrelated individuals. Direct observation and simulation experiments revealed that around 10% of common single nucleotide polymorphisms (SNPs) reside in regions with differences in the propensity for local DNA methylation between the two alleles. We further showed that for the most common form of SNP, a polymorphism at a CpG dinucleotide, the presence of the CpG at the SNP positively affected local DNA methylation in cis. Conclusions: Taken together with the known effect of DNA methylation on mutation rate, our results suggest an interesting interdependence between genetics and epigenetics underlying diversity in the human genome

Maternal nutrition at conception modulates DNA methylation of human metastable epialleles.

In experimental animals, maternal diet during the periconceptional period influences the establishment of DNA methylation at metastable epialleles in the offspring, with permanent phenotypic consequences. Pronounced naturally occurring seasonal differences in the diet of rural Gambian women allowed us to test this in humans. We show that significant seasonal variations in methyl-donor nutrient intake of mothers around the time of conception influence 13 relevant plasma biomarkers. The level of several of these maternal biomarkers predicts increased/decreased methylation at metastable epialleles in DNA extracted from lymphocytes and hair follicles in infants postnatally. Our results demonstrate that maternal nutritional status during early pregnancy causes persistent and systemic epigenetic changes at human metastable epialleles

A novel isolator-based system promotes viability of human embryos during laboratory processing

In vitro fertilisation (IVF) and related technologies are arguably the most challenging of all cell culture applications. The starting material is a single cell from which one aims to produce an embryo capable of establishing a pregnancy eventually leading to a live birth. Laboratory processing during IVF treatment requires open manipulations of gametes and embryos, which typically involves exposure to ambient conditions. To reduce the risk of cellular stress, we have developed a totally enclosed system of interlinked isolator-based workstations designed to maintain oocytes and embryos in a physiological environment throughout the IVF process. Comparison of clinical and laboratory data before and after the introduction of the new system revealed that significantly more embryos developed to the blastocyst stage in the enclosed isolator-based system compared with conventional open-fronted laminar flow hoods. Moreover, blastocysts produced in the isolator-based system contained significantly more cells and their development was accelerated. Consistent with this, the introduction of the enclosed system was accompanied by a significant increase in the clinical pregnancy rate and in the proportion of embryos implanting following transfer to the uterus. The data indicate that protection from ambient conditions promotes improved development of human embryos. Importantly, we found that it was entirely feasible to conduct all IVF-related procedures in the isolator-based workstations