35 research outputs found
Haptography: Capturing and Recreating the Rich Feel of Real Surfaces
Haptic interfaces, which allow a user to touch virtual and remote environments through a hand-held tool, have opened up exciting new possibilities for applications such as computer-aided design and robot-assisted surgery. Unfortunately, the haptic renderings produced by these systems seldom feel like authentic re-creations of the richly varied surfaces one encounters in the real world. We have thus envisioned the new approach of haptography, or haptic photography, in which an individual quickly records a physical interaction with a real surface and then recreates that experience for a user at a different time and/or place. This paper presents an overview of the goals and methods of haptography, emphasizing the importance of accurately capturing and recreating the high frequency accelerations that occur during tool-mediated interactions. In the capturing domain, we introduce a new texture modeling and synthesis method based on linear prediction applied to acceleration signals recorded from real tool interactions. For recreating, we show a new haptography handle prototype that enables the user of a Phantom Omni to feel fine surface features and textures
Modelling of strain effects in manganite films
Thickness dependence and strain effects in films of
perovskites are analyzed in the colossal magnetoresistance regime. The
calculations are based on a generalization of a variational approach previously
proposed for the study of manganite bulk. It is found that a reduction in the
thickness of the film causes a decrease of critical temperature and
magnetization, and an increase of resistivity at low temperatures. The strain
is introduced through the modifications of in-plane and out-of-plane electron
hopping amplitudes due to substrate-induced distortions of the film unit cell.
The strain effects on the transition temperature and transport properties are
in good agreement with experimental data only if the dependence of the hopping
matrix elements on the bond angle is properly taken into account.
Finally variations of the electron-phonon coupling linked to the presence of
strain turn out important in influencing the balance of coexisting phases in
the filmComment: 7 figures. To be published on Physical Review
Efficacy and Safety of Nivolumab Plus Ipilimumab in Patients With Advanced Hepatocellular Carcinoma Previously Treated With Sorafenib The CheckMate 040 Randomized Clinical Trial
IMPORTANCE Most patients with hepatocellular carcinoma (HCC) are diagnosed with
advanced disease not eligible for potentially curative therapies; therefore, new treatment
options are needed. Combining nivolumab with ipilimumab may improve clinical outcomes
compared with nivolumab monotherapy.
OBJECTIVE To assess efficacy and safety of nivolumab plus ipilimumab in patients with
advanced HCC who were previously treated with sorafenib.
DESIGN, SETTING, AND PARTICIPANTS CheckMate 040 is a multicenter, open-label,
multicohort, phase 1/2 study. In the nivolumab plus ipilimumab cohort, patients were
randomized between January 4 and September 26, 2016. Treatment group information was
blinded after randomization. Median follow-up was 30.7 months. Data cutoff for this analysis
was January 2019. Patients were recruited at 31 centers in 10 countries/territories in Asia,
Europe, and North America. Eligible patients had advanced HCC (with/without hepatitis B or
C) previously treated with sorafenib. A total of 148 patients were randomized (50 to arm A
and 49 each to arms B and C).
INTERVENTIONS Patients were randomized 1:1:1 to either nivolumab 1 mg/kg plus ipilimumab 3
mg/kg, administered every 3 weeks (4 doses), followed by nivolumab 240 mg every 2 weeks
(arm A); nivolumab 3 mg/kg plus ipilimumab 1 mg/kg, administered every 3 weeks (4 doses),
followed by nivolumab 240 mg every 2 weeks (arm B); or nivolumab 3 mg/kg every 2 weeks
plus ipilimumab 1 mg/kg every 6 weeks (arm C).
MAIN OUTCOMES AND MEASURES Coprimary end points were safety, tolerability, and objective
response rate. Duration of response was also measured (investigator assessed with the
Response Evaluation Criteria in Solid Tumors v1.1).
RESULTS Of 148 total participants, 120 were male (81%). Median (IQR) age was 60
(52.5-66.5). At data cutoff (January 2019), the median follow-up was 30.7 months (IQR,
29.9-34.7). Investigator-assessed objective response rate was 32% (95% CI, 20%-47%) in
arm A, 27% (95% CI, 15%-41%) in arm B, and 29% (95% CI, 17%-43%) in arm C. Median
(range) duration of response was not reached (8.3-33.7+) in arm A and was 15.2 months
(4.2-29.9+) in arm B and 21.7 months (2.8-32.7+) in arm C. Any-grade treatment-related
adverse events were reported in 46 of 49 patients (94%) in arm A, 35 of 49 patients (71%) in
arm B, and 38 of 48 patients (79%) in arm C; there was 1 treatment-related death (arm A;
grade 5 pneumonitis).
CONCLUSIONS AND RELEVANCE In this randomized clinical trial, nivolumab plus ipilimumab
had manageable safety, promising objective response rate, and durable responses. The arm A
regimen (4 doses nivolumab 1 mg/kg plus ipilimumab 3 mg/kg every 3 weeks then nivolumab
240 mg every 2 weeks) received accelerated approval in the US based on the results of this
study.
TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0165887
Compatibility Study Examining the Physical and Chemical Stability of Calcipotriene Ointment 0.005% with Three Topical Corticosteroids: Clobetasol Ointment 0.05%, Desoximetasone Ointment 0.25%, and Desoximetasone Ointment 0.05%
The effect of loading on sintering and catalytic activity of Pt/SiO2 hybrid catalyst powders synthesized via spray pyrolysis
Platinum (Pt) is commonly used as a heterogeneous catalyst to effectively convert carbon monoxide (CO)
from automobile exhaust gas into carbon dioxide (CO2). Platinum/silica (Pt/SiO2) hybrid catalyst powders with varying
Pt content were synthesized via a spray pyrolysis process. The average particle size and specific surface area of the
Pt nanoparticles on the Pt/SiO2 hybrid catalyst powders were characterized as-prepared and after heat treatment. As
the Pt loading increased, the Pt nanoparticles grew on the surface of the SiO2 as a result of sintering, and the catalytic
efficiency decreased. This work demonstrates that the Pt/SiO2 (4 wt% Pt) hybrid catalyst powder is suitable as a hightemperature
automobile exhaust catalyst, compared with the Pt/SiO2 hybrid catalyst powder with high Pt loading (14 wt%
Pt), indicating that metal nanoparticle loading is a key factor for determining catalytic activity.1541sciescopuskc