9 research outputs found
Randomizing world trade. II. A weighted network analysis
Based on the misleading expectation that weighted network properties always
offer a more complete description than purely topological ones, current
economic models of the International Trade Network (ITN) generally aim at
explaining local weighted properties, not local binary ones. Here we complement
our analysis of the binary projections of the ITN by considering its weighted
representations. We show that, unlike the binary case, all possible weighted
representations of the ITN (directed/undirected, aggregated/disaggregated)
cannot be traced back to local country-specific properties, which are therefore
of limited informativeness. Our two papers show that traditional macroeconomic
approaches systematically fail to capture the key properties of the ITN. In the
binary case, they do not focus on the degree sequence and hence cannot
characterize or replicate higher-order properties. In the weighted case, they
generally focus on the strength sequence, but the knowledge of the latter is
not enough in order to understand or reproduce indirect effects.Comment: See also the companion paper (Part I): arXiv:1103.1243
[physics.soc-ph], published as Phys. Rev. E 84, 046117 (2011
Alleles of the KIR2DL4 receptor and their lack of association with pre-eclampsia
A survey of KIR2DL4 polymorphism revealed seven common sequences in the Australian population. The seven sequences encode three different amino acid sequences of the immunoglobulin domains. Two of the sequences encoding different amino acid sequences in the immunoglobulin domains also occur on some chromosomes with a single nucleotide deletion at the end of exon 6, which encodes the transmembrane domain (ΔTM mutation), resulting in exon 6 skipping during mRNA production. Due to alternate splicing, a fraction of the mRNA produced by these alleles includes the transmembrane region but is missing the cytoplasmic region. The remaining two sequences differed only by synonymous substitutions. All of the exonic polymorphisms of KIR2DL4 could be detected by single-stranded conformational polymorphism of individually amplified exons. The ΔTM mutation is in linkage disequilibrium with the killer cell immunoglobulin-like receptor (KIR) A haplotype, and the wild-type sequence is in linkage disequilibrium with the B haplotype. The frequencies of alleles with the ΔTM mutation or Ig-domain polymorphisms did not differ between women who experienced pre-eclampsia and normotensive controls. Similarly there was no difference in the KIR gene repertoire in pre-eclampsia and normotensive controls