217 research outputs found
JCLAL: A Java framework for active learning
Active Learning has become an important area of research owing to the increasing number of real-world problems which contain labelled and unlabelled examples at the same time. JCLAL is a Java Class Library for Active Learning which has an architecture that follows strong principles of object-oriented design. It is easy to use, and it allows the developers to adapt, modify and extend the framework according to their needs. The library offers a variety of active learning methods that have been proposed in the literature. The software is available under the GPL license
Influence of Low-Degree High-Order p-Mode Splittings on the Solar Rotation Profile
The solar rotation profile is well constrained down to about 0.25 R thanks to
the study of acoustic modes. Since the radius of the inner turning point of a
resonant acoustic mode is inversely proportional to the ratio of its frequency
to its degree, only the low-degree p modes reach the core. The higher the order
of these modes, the deeper they penetrate into the Sun and thus they carry more
diagnostic information on the inner regions. Unfortunately, the estimates of
frequency splittings at high frequency from Sun-as-a-star measurements have
higher observational errors due to mode blending, resulting in weaker
constraints on the rotation profile in the inner core. Therefore inversions for
the solar internal rotation use only modes below 2.4 mHz for l < 4. In the work
presented here, we used an 11.5 year-long time series to compute the rotational
frequency splittings for modes l < 4 using velocities measured with the GOLF
instrument. We carried out a theoretical study of the influence of the
low-degree modes in the region 2 to 3.5 mHz on the inferred rotation profile as
a function of their error bars.Comment: Accepted for publication in Solar Physics. 17 Pages, 9 figure
Human antibody response to Zika targets type-specific quaternary structure epitopes
The recent Zika virus (ZIKV) epidemic in the Americas has revealed rare but serious manifestations of infection. ZIKV has emerged in regions endemic for dengue virus (DENV), a closely related mosquito-borne flavivirus. Cross-reactive antibodies confound studies of ZIKV epidemiology and pathogenesis. The immune responses to ZIKV may be different in people, depending on their DENV immune status. Here, we focus on the human B cell and antibody response to ZIKV as a primary flavivirus infection to define the properties of neutralizing and protective antibodies generated in the absence of preexisting immunity to DENV. The plasma antibody and memory B cell response is highly ZIKV type–specific, and ZIKV-neutralizing antibodies mainly target quaternary structure epitopes on the viral envelope. To map viral epitopes targeted by protective antibodies, we isolated 2 type-specific monoclonal antibodies (mAbs) from a ZIKV case. Both mAbs were strongly neutralizing in vitro and protective in vivo. The mAbs recognize distinct epitopes centered on domains I and II of the envelope protein. We also demonstrate that the epitopes of these mAbs define antigenic regions commonly targeted by plasma antibodies in individuals from endemic and nonendemic regions who have recovered from ZIKV infections
Towards a greater dialogue on disability between Muslims and Christians
Attitudes to disability and disabled people by Muslims – focusing on attitudes in the Middle East and North Africa - and Christians – focusing on the West (here taken to mean Europe, North America and Australasia) - were examined through a grounded theory literature search, with the study being divided into three phases of reading and analysis. The aims of study were to develop a dialogue on disability between the two cultures, to inform an understanding of the attitudes to disability in the two cultures, and to inform cultural practice in promoting support and equality in both cultures. The study finds that Islam and Christianity have much in common and are a force for good in promoting and developing disability equality in both Muslim and Christian cultures
Perspectives in Global Helioseismology, and the Road Ahead
We review the impact of global helioseismology on key questions concerning
the internal structure and dynamics of the Sun, and consider the exciting
challenges the field faces as it enters a fourth decade of science
exploitation. We do so with an eye on the past, looking at the perspectives
global helioseismology offered in its earlier phases, in particular the
mid-to-late 1970s and the 1980s. We look at how modern, higher-quality, longer
datasets coupled with new developments in analysis, have altered, refined, and
changed some of those perspectives, and opened others that were not previously
available for study. We finish by discussing outstanding challenges and
questions for the field.Comment: Invited review; to appear in Solar Physics (24 pages, 6 figures
Contemporary Clinical and Molecular Epidemiology of Vancomycin-Resistant Enterococcal Bacteremia: A Prospective Multicenter Cohort Study (VENOUS I)
Background: Vancomycin-resistant enterococci (VRE) are major therapeutic challenges. Prospective contemporary data characterizing the clinical and molecular epidemiology of VRE bloodstream infections (BSIs) are lacking. Methods: The Vancomycin-Resistant Enterococcal BSI Outcomes Study (VENOUS I) is a prospective observational cohort of adult patients with enterococcal BSI in 11 US hospitals. We included patients with Enterococcus faecalis or Enterococcus faecium BSI with ≥1 follow-up blood culture(s) within 7 days and availability of isolate(s) for further characterization. The primary study outcome was in-hospital mortality. Secondary outcomes were mortality at days 4, 7, 10, 12, and 15 after index blood culture. A desirability of outcome ranking was constructed to assess the association of vancomycin resistance with outcomes. All index isolates were subjected to whole genome sequencing. Results: Forty-two of 232 (18%) patients died in hospital and 39 (17%) exhibited microbiological failure (lack of clearance in the first 4 days). Neutropenia (hazard ratio [HR], 3.13), microbiological failure (HR, 2.4), VRE BSI (HR, 2.13), use of urinary catheter (HR, 1.85), and Pitt BSI score ≥2 (HR, 1.83) were significant predictors of in-hospital mortality. Microbiological failure was the strongest predictor of in-hospital mortality in patients with E faecium bacteremia (HR, 5.03). The impact of vancomycin resistance on mortality in our cohort changed throughout the course of hospitalization. Enterococcus faecalis sequence type 6 was a predominant multidrug-resistant lineage, whereas a heterogeneous genomic population of E faecium was identified. Conclusions: Failure of early eradication of VRE from the bloodstream is a major factor associated with poor outcomes
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The European Solar Telescope
The European Solar Telescope (EST) is a project aimed at studying the magnetic connectivity of the solar atmosphere, from the deep photosphere to the upper chromosphere. Its design combines the knowledge and expertise gathered by the European solar physics community during the construction and operation of state-of-the-art solar telescopes operating in visible and near-infrared wavelengths: the Swedish 1m Solar Telescope, the German Vacuum Tower Telescope and GREGOR, the French Télescope Héliographique pour l'Étude du Magnétisme et des Instabilités Solaires, and the Dutch Open Telescope. With its 4.2 m primary mirror and an open configuration, EST will become the most powerful European ground-based facility to study the Sun in the coming decades in the visible and near-infrared bands. EST uses the most innovative technological advances: the first adaptive secondary mirror ever used in a solar telescope, a complex multi-conjugate adaptive optics with deformable mirrors that form part of the optical design in a natural way, a polarimetrically compensated telescope design that eliminates the complex temporal variation and wavelength dependence of the telescope Mueller matrix, and an instrument suite containing several (etalon-based) tunable imaging spectropolarimeters and several integral field unit spectropolarimeters. This publication summarises some fundamental science questions that can be addressed with the telescope, together with a complete description of its major subsystems
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