48 research outputs found

    Measurement of the CP-violating weak phase φs and the decay width difference δΓc using the Bs 0→J/ψφ(1020) decay channel in pp collisions at √ s=8 TeV

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    The CP-violating weak phase ϕsϕs of the View the MathML sourceBs0 meson and the decay width difference ΔΓsΔΓs of the View the MathML sourceBs0 light and heavy mass eigenstates are measured with the CMS detector at the LHC using a data sample of View the MathML sourceBs0→J/ψϕ(1020)→μ+μ−K+K− decays. The analysed data set corresponds to an integrated luminosity of View the MathML source19.7fb−1 collected in pp collisions at a centre-of-mass energy of View the MathML source8TeV. A total of 49 200 reconstructed View the MathML sourceBs0 decays are used to extract the values of ϕsϕs and ΔΓsΔΓs by performing a time-dependent and flavour-tagged angular analysis of the μ+μ−K+K−μ+μ−K+K− final state. The weak phase is measured to be View the MathML sourceϕs=−0.075±0.097(stat)±0.031(syst) rad, and the decay width difference is View the MathML sourceΔΓs=0.095±0.013(stat)±0.007(syst) ps−1

    Colorectal surveillance in Lynch syndrome families

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    Cellular mechanisms in basic and clinical gastroenterology and hepatolog

    Revised guidelines for the clinical management of Lynch syndrome (HNPCC):recommendations by a group of European experts

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    <p>Lynch syndrome (LS) is characterised by the development of colorectal cancer, endometrial cancer and various other cancers, and is caused by a mutation in one of the mismatch repair genes: MLH1, MSH2, MSH6 or PMS2. In 2007, a group of European experts (the Mallorca group) published guidelines for the clinical management of LS. Since then substantial new information has become available necessitating an update of the guidelines. In 2011 and 2012 workshops were organised in Palma de Mallorca. A total of 35 specialists from 13 countries participated in the meetings. The first step was to formulate important clinical questions. Then a systematic literature search was performed using the Pubmed database and manual searches of relevant articles. During the workshops the outcome of the literature search was discussed in detail. The guidelines described in this paper may be helpful for the appropriate management of families with LS. Prospective controlled studies should be undertaken to improve further the care of these families.</p>
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