Genetic partitioning of interleukin-6 signalling in mice dissociates Stat3 from Smad3-mediated lung fibrosis

Idiopathic pulmonary fibrosis (IPF) is a fatal disease that is unresponsive to current therapies and characterized by excessive collagen deposition and subsequent fibrosis. While inflammatory cytokines, including interleukin (IL)-6, are elevated in IPF, the molecular mechanisms that underlie this disease are incompletely understood, although the development of fibrosis is believed to depend on canonical transforming growth factor (TGF)-β signalling. We examined bleomycin-induced inflammation and fibrosis in mice carrying a mutation in the shared IL-6 family receptor gp130. Using genetic complementation, we directly correlate the extent of IL-6-mediated, excessive Stat3 activity with inflammatory infiltrates in the lung and the severity of fibrosis in corresponding gp130757F mice. The extent of fibrosis was attenuated in B lymphocyte-deficient gp130757F;µMT−/− compound mutant mice, but fibrosis still occurred in their Smad3−/− counterparts consistent with the capacity of excessive Stat3 activity to induce collagen 1α1 gene transcription independently of canonical TGF-β/Smad3 signalling. These findings are of therapeutic relevance, since we confirmed abundant STAT3 activation in fibrotic lungs from IPF patients and showed that genetic reduction of Stat3 protected mice from bleomycin-induced lung fibrosis

The Inverse Scattering Method, Lie-Backlund Transformations and Solitons for Low-energy Effective Field Equations of 5D String Theory

In the framework of the 5D low-energy effective field theory of the heterotic string with no vector fields excited, we combine two non-linear methods in order to construct a solitonic field configuration. We first apply the inverse scattering method on a trivial vacuum solution and obtain an stationary axisymmetric two-soliton configuration consisting of a massless gravitational field coupled to a non-trivial chargeless dilaton and to an axion field endowed with charge. The implementation of this method was done following a scheme previously proposed by Yurova. We also show that within this scheme, is not possible to get massive gravitational solitons at all. We then apply a non-linear Lie-Backlund matrix transformation of Ehlers type on this massless solution and get a massive rotating axisymmetric gravitational soliton coupled to axion and dilaton fields endowed with charges. We study as well some physical properties of the constructed massless and massive solitons and discuss on the effect of the generalized solution generating technique on the seed solution and its further generalizations.Comment: 17 pages in latex, changed title, improved text, added reference

ULTRA HIGH FIELD MR CAROTID VESSEL WALL IMAGING: COMPARISON BETWEEN 7T AND 3T

Cardiovascular Aspects of Radiolog

Impacts of booming economic growth and urbanization on carbon dioxide emissions in Chinese megalopolises over 1985–2010: an index decomposition analysis

Given the booming economic growth and urbanization in China, cities have become crucial to sustaining this development and curbing national emissions. Understanding the key drivers underlying the rapid emissions growth is critical to providing local solutions for national climate targets. By using index decomposition analysis, we explore the factors contributing to the carbon dioxide (CO2) emissions in Chinese megalopolises from 1985 to 2010. An additional decomposition analysis of the industry sector is performed because of its dominant contribution to the total emissions. The booming economy and expanding urban areas are the major drivers to the increasing CO2 emissions in Chinese megalopolises over the examined period. The significant improvement in energy intensity is the primary factor for reducing CO2 emissions, the declining trend of which, however, has been suspended or reversed since 2000. The decoupling effect of the adjustments in the economic structure only occurred in three megalopolises, namely, the Yangtze River Delta (YRD), the Beijing-Tianjin-Heibei Megalopolis (BTJ), and the Pearl River Delta (PRD). In comparison, the impacts of urban density and carbon intensity are relatively marginal. The further disaggregated decomposition analysis in the industry sector shows that energy intensity improvements were widely achieved in 36 sub-industries in the PRD. The results also indicate the concentrations of energy-intensive industries in the PRD, posing a major challenge to local governments for a low-carbon economy. As economic growth and urbanization continue, reductions in energy intensity and clean energy therefore warrant much more policy attentions due to their crucial roles in reducing carbon emissions and satisfying the energy demand

Surface Kinetics and Generation of Different Terms in a Conservative Growth Equation

A method based on the kinetics of adatoms on a growing surface under epitaxial growth at low temperature in (1+1) dimensions is proposed to obtain a closed form of local growth equation. It can be generalized to any growth problem as long as diffusion of adatoms govern the surface morphology. The method can be easily extended to higher dimensions. The kinetic processes contributing to various terms in the growth equation (GE) are identified from the analysis of in-plane and downward hops. In particular, processes corresponding to the (h -> -h) symmetry breaking term and curvature dependent term are discussed. Consequence of these terms on the stable and unstable transition in (1+1) dimensions is analyzed. In (2+1) dimensions it is shown that an additional (h -> -h) symmetry breaking term is generated due to the in-plane curvature associated with the mound like structures. This term is independent of any diffusion barrier differences between in-plane and out of-plane migration. It is argued that terms generated in the presence of downward hops are the relevant terms in a GE. Growth equation in the closed form is obtained for various growth models introduced to capture most of the processes in experimental Molecular Beam Epitaxial growth. Effect of dissociation is also considered and is seen to have stabilizing effect on the growth. It is shown that for uphill current the GE approach fails to describe the growth since a given GE is not valid over the entire substrate.Comment: 14 pages, 7 figure

Losses of chromosomes 1p and 3q are early genetic events in the development of sporadic pheochromocytomas

Despite several loss of heterozygosity studies, a comprehensive genomic survey of pheochromocytomas is still lacking. To identify DNA copy number changes which might be important in tumor development and progression and which may have diagnostic utility, we evaluated genetic aberrations in 29 sporadic adrenal and extra-adrenal pheochromocytomas (19 clinically benign tumors and 10 malignant lesions). Comparative genomic hybridization was performed using directly fluorochrome-conjugated DNA extracted from frozen (16) and paraffin-embedded (13) tumor tissues. The most frequently observed changes were losses of chromosomes 1p11-p32 (86%), 3q (52%), 6q (34%), 3p, 17p (31% each), 11q (28%), and gains of chromosomes 9q (38%) and 17q (31%). No amplification was identified and no difference between adrenal and extra-adrenal tumors was detected. Progression to malignant tumors was strongly associated with deletions of chromosome 6q (60% versus 21% in clinically benign lesions, P = 0.0368) and 17p (50% versus 21%). Fluorescence in situ hybridization confirmed the comparative genomic hybridization data of chromosomes 1p, 3q, and 6q, and revealed aneuploidy in some tumors. Our results suggest that the development of pheochromocytomas is associated with specific genomic aberrations, such as losses of 1p, 3q, and 6q and gains of 9q and 17q. In particular, tumor suppressor genes on chromosomes 1p and 3q may be involved in early tumorigenesis, and deletions of chromosomes 6q and 17p in progression to malignancy

Forward K+ production in subthreshold pA collisions at 1.0 GeV

K+ meson production in pA (A = C, Cu, Au) collisions has been studied using the ANKE spectrometer at an internal target position of the COSY-Juelich accelerator. The complete momentum spectrum of kaons emitted at forward angles, theta < 12 degrees, has been measured for a beam energy of T(p)=1.0 GeV, far below the free NN threshold of 1.58 GeV. The spectrum does not follow a thermal distribution at low kaon momenta and the larger momenta reflect a high degree of collectivity in the target nucleus.Comment: 4 pages, 3 figure

Quark Imaging in the Proton Via Quantum Phase-Space Distributions

We develop the concept of quantum phase-space (Wigner) distributions for quarks and gluons in the proton. To appreciate their physical content, we analyze the contraints from special relativity on the interpretation of elastic form factors, and examine the physics of the Feynman parton distributions in the proton's rest frame. We relate the quark Wigner functions to the transverse-momentum dependent parton distributions and generalized parton distributions, emphasizing the physical role of the skewness parameter. We show that the Wigner functions allow to visualize quantum quarks and gluons using the language of the classical phase space. We present two examples of the quark Wigner distributions and point out some model-independent features.Comment: 20 pages with 3 fiture

The role of myocardial innervation imaging in different clinical scenarios: an expert document of the European Association of Cardiovascular Imaging and Cardiovascular Committee of the European Association of Nuclear Medicine

Cardiac sympathetic activity plays a key role in supporting cardiac function in both health and disease conditions, and nuclear cardiac imaging has always represented the only way for the non-invasive evaluation of the functional integrity of cardiac sympathetic terminals, mainly through the use of radiopharmaceuticals that are analogues of norepinephrine and, in particular, with the use of I-123-mIBG imaging. This technique demonstrates the presence of cardiac sympathetic dysfunction in different cardiac pathologies, linking the severity of sympathetic nervous system impairment to adverse patient's prognosis. This article will outline the state-of-the-art of cardiac I-123-mIBG imaging and define the value and clinical applications in the different fields of cardiovascular diseases.Cardiolog