Mass chemotherapy in Bilharzia in Northern Transvaal

No Abstract

Electron microscopic studies on corriparta virus

The articles have been scanned in colour with a HP Scanjet 5590; 300dpi. Adobe Acrobat XI Pro was used to OCR the text and also for the merging and conversion to the final presentation PDF-format

Electron microscopic studies on equine encephalosis virus

Electron microscopic studies carried out on thin sections of BHK 21 cells infected with equine encephalosis virus (EEV) have revealed a fine cytopathology closely resembling that shown by bluetongue and African horsesickness viruses. The characteristics include the presence of granular inclusion bodies from which mature virus particles appear to arise, swelling of the rough endoplasmic reticulum and the presence of inclusion bodies in the mitochondrial matrix. The diameter of the sectioned virus particle is approximately 73 nm, and 60 nm when negatively stained. The experimental observations suggest that the capsid is composed of 32 morphological subunits.The articles have been scanned in colour with a HP Scanjet 5590; 300dpi. Adobe Acrobat XI Pro was used to OCR the text and also for the merging and conversion to the final presentation PDF-format

Phenytoin as a last-resort treatment in SCN8A encephalopathy.

Contains fulltext : 175085.pdf (publisher's version ) (Open Access

Opera omnia Desiderii Erasmi Roterodami

The Apologia respondens ad ea quae Jacobus Lopis Stunica taxauerat in prima duntaxat Noui Testamenti aeditione is Erasmus' first apology against the Spaniard Stunica. Erasmus himself classed it under the eighth 'ordo' of his works, that is, the 'ordo' of his apologies; see Ep. I to Botzheim, 30 January 1523, p. 4 I, 1. 22, and cf. Ep. 2283 to Boece, 15 March 1530, 1. 189. Since the editors of BAS reserved the seventh 'ordo' ('tomus' in their terminology) for the Paraphrasis in Nouum Testamentum, in accordance with Erasmus' direction in the letter to Botzheim (Ep. I, p. 41, 1. 8), and the next 'ordo' for the translations from the Church Fathers, in accordance with the letter to Boece (Ep. 2283, 1. 155), the collected apologies eventually became the ninth 'ordo', not the eighth. In the present edition, the ~rst apology against Stunica is the second volume of the ninth 'ordo'. Four further apologies against Stunica and that against Carranza will form, or form part of, another volume. Interestingly enough, the first apology against Stunica is the first work of Erasmus whose final authentic redaction turns out not to be contained in an edition printed during Erasmus' lifetime, but in BAS. This remarkable fact as well as its consequences for the pres~nt edition will be discussed in detail in the Introduction, chapter VI. In addition to those who, at the request of the editorial board, took charge of the supervision of this volume and whose names are recorded on the verso of the title-page, M. de Jonge of Leiden has kindly read and criticized the typescript. The editorial board and the editor of the present volume thank all libraries who put books, photostats, microfilms and bibliographical material at theirdisposal. They would also like to thank Mrs Anna de Haas of the NorthHolland Publishing Company for the valuable assistance she has rendered in seeing this volume through the press

Merosin deficient congenital muscular dystrophy type 1A:An international workshop on the road to therapy 15-17 November 2019 Maastricht, the Netherlands

Item does not contain fulltex

Extreme Value Statistics in Semi-Supervised Models

We consider extreme value analysis in a semi-supervised setting, where we observe, next to the n data on the target variable, n + m data on one or more covariates. This is called the semi-supervised model with n labeled and m unlabeled data. By exploiting the tail dependence between the target variable and the covariates, we derive estimators for the extreme value index and extreme quantiles of the target variable in this setting and establish their asymptotic behavior. Our estimators substantially improve the univariate estimators, based on only the n target variable data, in terms of asymptotic variances whereas the asymptotic biases remain unchanged. A simulation study confirms the substantially improved behavior of both estimators. Finally the estimation method is applied to rainfall data in France. Supplementary materials for this article are available online, including a standardized description of the materials available for reproducing the work

Environmental and genetic trends in clean fleece mass, live mass and fiber diameter in selection and control flocks involving a selection experiment for increased clean fleece mass in South African Merino sheep

This study was undertaken to investigate the genetic stability of an unselected Conlrol Group of South African Merino sheep and genetic change in a flock selected for increased clean fleece mass (Selection Group) under the same environmental conditions. Data regarding 14-17 months clean fleece mass (CFM) and fibre diameter (FD) of 5867 progeny from these groups (3186 and 2681 individuals in the Selection and Conlrol Groups, respectively) were analysed to investigate genetic change over the period 1969-1989. A smaller data set, involving 5273 progeny (2782 and 2491 individuals in the respective groups) born in 1971-1989, was used to investigate change in 16-17 month live mass (LM). An animal model was used to obtain predicted breeding values (PBVs) for all individuals by mixed model analysis (MMA). Average PBVs of Selection and Conlrol group progeny within birth years were taken as a measure of genetic change, rendering genetic trends independent from environmental bias. Genetic change in the Selection Group was also obtained by deviating average PBVs from those obtained in the Control Group. This approach is analogous to the method of expressing genetic change as least squares deviations of Selection Group progeny from Control Group contemporaries, and will be affected by genetic change in the Control Group. Prior heritability estimates, derived for the MMA by paternal halfsib procedures, were within ranges reported in the literature. Year-to-year variation, as derived from environmental trends from the MMA, appeared to be less for FD when compared to LM and CFM. Average PBVs for Control Group progeny increased (