55 research outputs found
Management of multiple drug-resistant tuberculosis
AbstractThere has been a worldwide increase in multiple drug-resistant tuberculosis (MDR-TB) which has in the past been associated with a poor prognosis. In the U.K., about half of the cases live in the London area and we have set out to obtain further information on their treatment and outcome. We examined the risk factors, drug resistance, drug treatment, sputum conversion, and outcome in patients with MDR-TB at three hospitals in South London and diagnosed during the period June 1995–January 1999. Human Immunodeficiency Virus (HIV)-positive patients were excluded. There were 760 patients resident in Lambeth, Southwark and Lewisham Health Authority (LSLHA) who were notified as tuberculosis (TB) during the time period and who were of negative or unknown HIV status. (The population of LSLHA is approx. 750 000.) There was a total of 13 patients with MDR-TB, known or presumed to be HIV negative. Their median age was 28 years (range 15–53); nine (69%) were born outside the U.K. and 11 had pulmonary disease; they had organisms resistant to a median of two first-line drugs (range 2–4) and to a median of four of all drugs tested (range 2–10). They received treatment with a median of six drugs (range 3–9). Eight were followed up for at least 3 years (range 3–6) after the completion of treatment; at their last assessment none had features of active TB and all were sputum negative (smear and culture). Two returned to their countries of origin during treatment; they were sputum negative at that time. Two patients are well and continue on treatment in the U.K. One patient (known HIV negative) died following treatment failure. In conclusion, we obtained disease-free survival in eight cases of MDR-TB, known or presumed to be HIV negative and followed up for 3 years or more. The prognosis for patients treated at specialised centres is good (and better than is generally believed). We describe a new protocol for the detection and management of MDR-TB
All-optical versus electro-optical quantum-limited feedback
All-optical feedback can be effected by putting the output of a source cavity
through a Faraday isolator and into a second cavity which is coupled to the
source cavity by a nonlinear crystal. If the driven cavity is heavily damped,
then it can be adiabatically eliminated and a master equation or quantum
Langevin equation derived for the first cavity alone. This is done for an input
bath in an arbitrary state, and for an arbitrary nonlinear coupling. If the
intercavity coupling involves only the intensity (or one quadrature) of the
driven cavity, then the effect on the source cavity is identical to that which
can be obtained from electro-optical feedback using direct (or homodyne)
detection. If the coupling involves both quadratures, this equivalence no
longer holds, and a coupling linear in the source amplitude can produce a
nonclassical state in the source cavity. The analogous electro-optic scheme
using heterodyne detection introduces extra noise which prevents the production
of nonclassical light. Unlike the electro-optic case, the all-optical feedback
loop has an output beam (reflected from the second cavity). We show that this
may be squeezed, even if the source cavity remains in a classical state.Comment: 21 pages. This is an old (1994) paper, but one which I thought was
worth posting because in addition to what is described in abstract it has:
(1) the first formulation (to my knowledge) of quantum trajectories for an
arbitrary (i.e. squeezed, thermal etc.) broadband bath; (2) the prediction of
a periodic modification to the detuning and damping of an oscillator for the
simplest sort of all-optical feedback (i.e. a mirror) as seen in the recent
experiment "Forces between a Single Atom and Its Distant Mirror Image", P.
Bushev et al, Phys. Rev. Lett. 92, 223602 (2004
Creating number states in the micromaser using feedback
We use the quantum theory of feedback developed by Wiseman and Milburn [Phys. Rev. Lett. 70, 548 (1993)] and Wiseman [Phys. Rev. A 49, 2133 (1994)] to investigate the photon-number noise properties of the micromaser with direct detection feedback. We find that the feedback can significantly reduce the amount of noise in the photon number. Under the right conditions the feedback locks the systems onto a number state. As opposed to other schemes in the past [P. Meystre, Opt. Lett. 12, 669 (1987); J. Krause, M. O. Scully, and H. Walther, Phys. Rev. A 36, 4547 (1987)], we can fix the number states to which the system evolves. We also simulate the micromaser using the quantum-trajectories method and show that these results agree with the quantum theory of feedback. We show that the noise of quantum island states [P. Bogar, J. A. Bergou, and M. Hillary, Phys. Rev. A 50, 754 (1994)] can be significantly reduced by the feedback
Continuous Quantum Measurement and the Quantum to Classical Transition
While ultimately they are described by quantum mechanics, macroscopic
mechanical systems are nevertheless observed to follow the trajectories
predicted by classical mechanics. Hence, in the regime defining macroscopic
physics, the trajectories of the correct classical motion must emerge from
quantum mechanics, a process referred to as the quantum to classical
transition. Extending previous work [Bhattacharya, Habib, and Jacobs, Phys.
Rev. Lett. {\bf 85}, 4852 (2000)], here we elucidate this transition in some
detail, showing that once the measurement processes which affect all
macroscopic systems are taken into account, quantum mechanics indeed predicts
the emergence of classical motion. We derive inequalities that describe the
parameter regime in which classical motion is obtained, and provide numerical
examples. We also demonstrate two further important properties of the classical
limit. First, that multiple observers all agree on the motion of an object, and
second, that classical statistical inference may be used to correctly track the
classical motion.Comment: 12 pages, 4 figures, Revtex
Feedback-control of quantum systems using continuous state-estimation
We present a formulation of feedback in quantum systems in which the best
estimates of the dynamical variables are obtained continuously from the
measurement record, and fed back to control the system. We apply this method to
the problem of cooling and confining a single quantum degree of freedom, and
compare it to current schemes in which the measurement signal is fed back
directly in the manner usually considered in existing treatments of quantum
feedback. Direct feedback may be combined with feedback by estimation, and the
resulting combination, performed on a linear system, is closely analogous to
classical LQG control theory with residual feedback.Comment: 12 pages, multicol revtex, revised and extende
Sensitivity to measurement perturbation of single atom dynamics in cavity QED
We consider continuous observation of the nonlinear dynamics of single atom
trapped in an optical cavity by a standing wave with intensity modulation. The
motion of the atom changes the phase of the field which is then monitored by
homodyne detection of the output field. We show that the conditional Hilbert
space dynamics of this system, subject to measurement induced perturbations,
depends strongly on whether the corresponding classical dynamics is regular or
chaotic. If the classical dynamics is chaotic the distribution of conditional
Hilbert space vectors corresponding to different observation records tends to
be orthogonal. This is a characteristic feature of hypersensitivity to
perturbation for quantum chaotic systems.Comment: 11 pages, 6 figure
Multipartite Entanglement and Quantum State Exchange
We investigate multipartite entanglement in relation to the theoretical
process of quantum state exchange. In particular, we consider such entanglement
for a certain pure state involving two groups of N trapped atoms. The state,
which can be produced via quantum state exchange, is analogous to the
steady-state intracavity state of the subthreshold optical nondegenerate
parametric amplifier. We show that, first, it possesses some 2N-way
entanglement. Second, we place a lower bound on the amount of such entanglement
in the state using a novel measure called the entanglement of minimum bipartite
entropy.Comment: 12 pages, 4 figure
Effect of dissipation and measurement on a tunneling system
We consider a parametrically driven Kerr medium in which the pumping may be sinusoidally varied. It has been previously found that this system exhibits coherent tunneling between two fixed points which can be either enhanced or suppressed by altering the driving frequency and strength. We numerically investigate the dynamics when damping is included. This is done both by solving a master equation and using the quantum-trajectory method. In the latter case it is also possible to model the result of a continuous heterodyne measurement of the cavity output. The dissipation destroys the coherences which give rise to the tunneling, causing the sinusoidal oscillation of the mean to give way to a stochastic jumping between the fixed points, manifested as a random telegraph signal. In the quantum-trajectory picture we show that the coherences responsible for tunneling are an exponentially decreasing function of the signal-to-noise ratio for heterodyne measurements. However, evidence of both the bare tunneling rate and the driving modified tunneling rate are still apparent in the random telegraph signal
Classical dynamics of a two-species Bose-Einstein condensate in the presence of nonlinear maser processes
The stability analysis of a generalized Dicke model, in the semi-classical
limit, describing the interaction of a two-species Bose-Einstein condensate
driven by a quantized field in the presence of Kerr and spontaneous parametric
processes is presented. The transitions from Rabi to Josephson dynamics are
identified depending on the relative value of the involved parameters.
Symmetry-breaking dynamics are shown for both types of coherent oscillations
due to the quantized field and nonlinear optical processes.Comment: 12 pages, 5 figures. Accepted for publication as chapter in
"Spontaneous Symmetry Breaking, Self-Trapping, and Josephson Oscillations in
Nonlinear Systems
Interpretation of quantum jump and diffusion-processes illustrated on the Bloch sphere
It is shown that the evolution of an open quantum system whose density operator obeys a Markovian master equation can in some cases be meaningfully described in terms of stochastic Schrödinger equations (SSE’s) for its state vector. A necessary condition for this is that the information carried away from the system by the bath (source of the irreversibility) be recoverable. The primary field of application is quantum optics, where the bath consists of the continuum of electromagnetic modes. The information lost from the system can be recovered using a perfect photodetector. The state of the system conditioned on the photodetections undergoes stochastic quantum jumps. Alternative measurement schemes on the outgoing light (homodyne and heterodyne detection) are shown to give rise to SSE’s with diffusive terms. These three detection schemes are illustrated on a simple quantum system, the two-level atom, giving new perspectives on the interpretation of measurement results. The reality of these and other stochastic processes for state vectors is discussed
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