89 research outputs found
The proportion of postmenopausal breast cancer cases in the Netherlands attributable to lifestyle-related risk factors
We aimed to estimate the proportion of Dutch postmenopausal breast cancer cases in 2010 that is attributable to lifestyle-related risk factors. We calculated population attributable fractions (PAFs) of potentially modifiable risk factors for postmenopausal breast cancer in Dutch women aged >50 in 2010. First, age-specific PAFs were calculated for each risk factor, based on their relative risks for postmenopausal breast cancer (from meta-analyses) and age-specific prevalence in the population (from national surveys) around the year 2000, assuming a latency period of 10 years. To obtain the overall PAF, age-specific PAFs were summed in a weighted manner, using the age-specific breast cancer incidence rates (2010) as weights. 95 % confidence intervals for PAF estimates were derived by Monte Carlo simulations. Of Dutch women >40 years, in 2000, 51 % were overweight/obese, 55 % physically inactive (<5 days/week 30 min activity), 75 % regularly consumed alcohol, 42 % ever smoked cigarettes and 79 % had a low-fibre intake (<3.4 g/1000 kJ/day). These factors combined had a PAF of 25.7 % (95 % CI 24.2–27.2), corresponding to 2,665 Dutch postmenopausal breast cancer cases in 2010. PAFs were 8.8 % (95 % CI 6.3–11.3) for overweight/obesity, 6.6 % (95 % CI 5.2–8.0) for alcohol consumption, 5.5 % (95 % CI 4.0–7.0) for physical inactivity, 4.6 % (95 % CI 3.3–6.0) for smoking and 3.2 % (95 % CI 1.6–4.8) for low-fibre intake. Our findings imply that modifiable risk factors are jointly responsible for approximately one out of four Dutch postmenopausal breast cancer cases. This suggests that incidence rates can be lowered substantially by living a more healthy lifestyle
Decay constants, light quark masses and quark mass bounds from light quark pseudoscalar sum rules
The flavor and pseudoscalar correlators are investigated using
families of finite energy sum rules (FESR's) known to be very accurately
satisfied in the isovector vector channel. It is shown that the combination of
constraints provided by the full set of these sum rules is sufficiently strong
to allow determination of both the light quark mass combinations ,
and the decay constants of the first excited pseudoscalar mesons in
these channels. The resulting masses and decay constants are also shown to
produce well-satisfied Borel transformed sum rules, thus providing non-trivial
constraints on the treatment of direct instanton effects in the FESR analysis.
The values of and obtained are in good agreement with the
values implied by recent hadronic decay analyses and the ratios obtained
from ChPT. New light quark mass bounds based on FESR's involving weight
functions which strongly suppress spectral contributions from the excited
resonance region are also presented.Comment: 28 pages, 10 figure
Towards resolution of the enigmas of P-wave meson spectroscopy
The mass spectrum of P-wave mesons is considered in a nonrelativistic
constituent quark model. The results show the common mass degeneracy of the
isovector and isodoublet states of the scalar and tensor meson nonets, and do
not exclude the possibility of a similar degeneracy of the same states of the
axial-vector and pseudovector nonets. Current experimental hadronic and \tau
-decay data suggest, however, a different scenario leading to the a_1 meson
mass \simeq 1190 MeV and the K_{1A}-K_{1B} mixing angle \simeq (37\pm 3)^o.
Possible s\bar{s} states of the four nonets are also discussed.Comment: 22 pages, LaTe
Efeito de Estratégia de Suplementação com Concentrado no Desempenho de Cabras Mestiças Saanen, em Dois Sistemas de Produção
Correlação entre crescimento e produtividade de cultivares de café em diferentes regiões de Minas Gerais, Brasil
Anticorpo monoclonal contra uma proteína macho-específica de 19 kDa em espermatozóides bovinos: uma metodologia promissora para imunosexagem
Rectal Organoids Enable Personalized Treatment of Cystic Fibrosis
In vitro drug tests using patient-derived stem cell
cultures offer opportunities to individually select
efficacious treatments. Here, we provide a study
that demonstrates that in vitro drug responses in
rectal organoids from individual patients with cystic
fibrosis (CF) correlate with changes in two in vivo
therapeutic endpoints. We measured individual
in vitro efficaciousness using a functional assay
in rectum-derived organoids based on forskolininduced swelling and studied the correlation with
in vivo effects. The in vitro organoid responses correlated with both change in pulmonary response and
change in sweat chloride concentration. Receiver
operating characteristic curves indicated good-toexcellent accuracy of the organoid-based test for
defining clinical responses. This study indicates
that an in vitro assay using stem cell cultures can prospectively select efficacious treatments for patients
and suggests that biobanked stem cell resources
can be used to tailor individual treatments in a
cost-effective and patient-friendly manner
Síndromes de dispersão de diásporos das espécies de trechos de vegetação ciliar do rio das Pacas, Querência - MT
Non-AIDS defining cancers in the D:A:D Study-time trends and predictors of survival : a cohort study
BACKGROUND:Non-AIDS defining cancers (NADC) are an important cause of morbidity and mortality in HIV-positive individuals. Using data from a large international cohort of HIV-positive individuals, we described the incidence of NADC from 2004-2010, and described subsequent mortality and predictors of these.METHODS:Individuals were followed from 1st January 2004/enrolment in study, until the earliest of a new NADC, 1st February 2010, death or six months after the patient's last visit. Incidence rates were estimated for each year of follow-up, overall and stratified by gender, age and mode of HIV acquisition. Cumulative risk of mortality following NADC diagnosis was summarised using Kaplan-Meier methods, with follow-up for these analyses from the date of NADC diagnosis until the patient's death, 1st February 2010 or 6 months after the patient's last visit. Factors associated with mortality following NADC diagnosis were identified using multivariable Cox proportional hazards regression.RESULTS:Over 176,775 person-years (PY), 880 (2.1%) patients developed a new NADC (incidence: 4.98/1000PY [95% confidence interval 4.65, 5.31]). Over a third of these patients (327, 37.2%) had died by 1st February 2010. Time trends for lung cancer, anal cancer and Hodgkin's lymphoma were broadly consistent. Kaplan-Meier cumulative mortality estimates at 1, 3 and 5 years after NADC diagnosis were 28.2% [95% CI 25.1-31.2], 42.0% [38.2-45.8] and 47.3% [42.4-52.2], respectively. Significant predictors of poorer survival after diagnosis of NADC were lung cancer (compared to other cancer types), male gender, non-white ethnicity, and smoking status. Later year of diagnosis and higher CD4 count at NADC diagnosis were associated with improved survival. The incidence of NADC remained stable over the period 2004-2010 in this large observational cohort.CONCLUSIONS:The prognosis after diagnosis of NADC, in particular lung cancer and disseminated cancer, is poor but has improved somewhat over time. Modifiable risk factors, such as smoking and low CD4 counts, were associated with mortality following a diagnosis of NADC
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