611 research outputs found
Transition from fractal to non-fractal scalings in growing scale-free networks
Real networks can be classified into two categories: fractal networks and
non-fractal networks. Here we introduce a unifying model for the two types of
networks. Our model network is governed by a parameter . We obtain the
topological properties of the network including the degree distribution,
average path length, diameter, fractal dimensions, and betweenness centrality
distribution, which are controlled by parameter . Interestingly, we show
that by adjusting , the networks undergo a transition from fractal to
non-fractal scalings, and exhibit a crossover from `large' to small worlds at
the same time. Our research may shed some light on understanding the evolution
and relationships of fractal and non-fractal networks.Comment: 7 pages, 3 figures, definitive version accepted for publication in
EPJ
Role of fractal dimension in random walks on scale-free networks
Fractal dimension is central to understanding dynamical processes occurring
on networks; however, the relation between fractal dimension and random walks
on fractal scale-free networks has been rarely addressed, despite the fact that
such networks are ubiquitous in real-life world. In this paper, we study the
trapping problem on two families of networks. The first is deterministic, often
called -flowers; the other is random, which is a combination of
-flower and -flower and thus called hybrid networks. The two
network families display rich behavior as observed in various real systems, as
well as some unique topological properties not shared by other networks. We
derive analytically the average trapping time for random walks on both the
-flowers and the hybrid networks with an immobile trap positioned at an
initial node, i.e., a hub node with the highest degree in the networks. Based
on these analytical formulae, we show how the average trapping time scales with
the network size. Comparing the obtained results, we further uncover that
fractal dimension plays a decisive role in the behavior of average trapping
time on fractal scale-free networks, i.e., the average trapping time decreases
with an increasing fractal dimension.Comment: Definitive version published in European Physical Journal
Effects of dimensionality and anisotropy on the Holstein polaron
We apply weak-coupling perturbation theory and strong-coupling perturbation
theory to the Holstein molecular crystal model in order to elucidate the
effects of anisotropy on polaron properties in D dimensions. The ground state
energy is considered as a primary criterion through which to study the effects
of anisotropy on the self-trapping transition, the self-trapping line
associated with this transition, and the adiabatic critical point. The effects
of dimensionality and anisotropy on electron-phonon correlations and polaronic
mass enhancement are studied, with particular attention given to the polaron
radius and the characteristics of quasi-1D and quasi-2D structures.
Perturbative results are confirmed by selected comparisons with variational
calculations and quantum Monte Carlo data
The K\"ahler-Ricci flow with positive bisectional curvature
We show that the K\"ahler-Ricci flow on a manifold with positive first Chern
class converges to a K\"ahler-Einstein metric assuming positive bisectional
curvature and certain stability conditions.Comment: 15 page
Polaron Effective Mass, Band Distortion, and Self-Trapping in the Holstein Molecular Crystal Model
We present polaron effective masses and selected polaron band structures of
the Holstein molecular crystal model in 1-D as computed by the Global-Local
variational method over a wide range of parameters. These results are augmented
and supported by leading orders of both weak- and strong-coupling perturbation
theory. The description of the polaron effective mass and polaron band
distortion that emerges from this work is comprehensive, spanning weak,
intermediate, and strong electron-phonon coupling, and non-adiabatic, weakly
adiabatic, and strongly adiabatic regimes. Using the effective mass as the
primary criterion, the self-trapping transition is precisely defined and
located. Using related band-shape criteria at the Brillouin zone edge, the
onset of band narrowing is also precisely defined and located. These two lines
divide the polaron parameter space into three regimes of distinct polaron
structure, essentially constituting a polaron phase diagram. Though the
self-trapping transition is thusly shown to be a broad and smooth phenomenon at
finite parameter values, consistency with notion of self-trapping as a critical
phenomenon in the adiabatic limit is demonstrated. Generalizations to higher
dimensions are considered, and resolutions of apparent conflicts with
well-known expectations of adiabatic theory are suggested.Comment: 28 pages, 15 figure
Shapes, contact angles, and line tensions of droplets on cylinders
Using an interface displacement model we calculate the shapes of
nanometer-size liquid droplets on homogeneous cylindrical surfaces. We
determine effective contact angles and line tensions, the latter defined as
excess free energies per unit length associated with the two contact lines at
the ends of the droplet. The dependences of these quantities on the cylinder
radius and on the volume of the droplets are analyzed.Comment: 26 pages, RevTeX, 10 Figure
Analysis of the intraspinal calcium dynamics and its implications on the plasticity of spiking neurons
The influx of calcium ions into the dendritic spines through the
N-metyl-D-aspartate (NMDA) channels is believed to be the primary trigger for
various forms of synaptic plasticity. In this paper, the authors calculate
analytically the mean values of the calcium transients elicited by a spiking
neuron undergoing a simple model of ionic currents and back-propagating action
potentials. The relative variability of these transients, due to the stochastic
nature of synaptic transmission, is further considered using a simple Markov
model of NMDA receptos. One finds that both the mean value and the variability
depend on the timing between pre- and postsynaptic action-potentials. These
results could have implications on the expected form of synaptic-plasticity
curve and can form a basis for a unified theory of spike time-dependent, and
rate based plasticity.Comment: 14 pages, 10 figures. A few changes in section IV and addition of a
new figur
Sensitive detection of colorectal cancer in peripheral blood by septin 9 DNA methylation assay
BACKGROUND: Colorectal cancer (CRC) is the second leading cause of cancer deaths despite the fact that detection of this cancer in early stages results in over 90% survival rate. Currently less than 45% of at-risk individuals in the US are screened regularly, exposing a need for better screening tests. We performed two case-control studies to validate a blood-based test that identifies methylated DNA in plasma from all stages of CRC. METHODOLOGY/PRINCIPAL FINDINGS: Using a PCR assay for analysis of Septin 9 (SEPT9) hypermethylation in DNA extracted from plasma, clinical performance was optimized on 354 samples (252 CRC, 102 controls) and validated in a blinded, independent study of 309 samples (126 CRC, 183 controls). 168 polyps and 411 additional disease controls were also evaluated. Based on the training study SEPT9-based classification detected 120/252 CRCs (48%) and 7/102 controls (7%). In the test study 73/126 CRCs (58%) and 18/183 control samples (10%) were positive for SEPT9 validating the training set results. Inclusion of an additional measurement replicate increased the sensitivity of the assay in the testing set to 72% (90/125 CRCs detected) while maintaining 90% specificity (19/183 for controls). Positive rates for plasmas from the other cancers (11/96) and non-cancerous conditions (41/315) were low. The rate of polyp detection (>1 cm) was approximately 20%. CONCLUSIONS/SIGNIFICANCE: Analysis of SEPT9 DNA methylation in plasma represents a straightforward, minimally invasive method to detect all stages of CRC with potential to satisfy unmet needs for increased compliance in the screening population. Further clinical testing is warranted
Antiflow of kaons in relativistic heavy ion collisions
We compare relativistic transport model calculations to recent data on the
sideward flow of neutral strange K^0_s mesons for Au+Au collisions at 6 AGeV. A
soft nuclear equation of state is found to describe very well the positive
proton flow data measured in the same experiment. In the absence of kaon
potential, the K^0 flow pattern is similar to that of protons. The kaon flow
becomes negative if a repulsive kaon potential determined from the impulse
approximation is introduced. However, this potential underestimates the data
which exhibits larger antiflow. An excellent agreement with the data is
obtained when a relativistic scalar-vector kaon potential, that has stronger
density dependence, is used. We further find that the transverse momentum
dependence of directed and elliptic flow is quite sensitive to the kaon
potential in dense matter.Comment: 5 pages, Revtex, 4 figure
The dissipative potential induced by QCD at finite temperature and density
In the framework of QCD at finite temperature we have obtained dissipative
terms for the effective potential between and which would partly
explain the suppression in the Quark Gluon Plasma (QGP). The
derivation of the dissipative potential for QGP is presented and the case for
Hadron Matter (HM) is briefly discussed. The suppression effects are estimated
based on simple approximations.Comment: 13 page
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