598 research outputs found
On the formation and decay of a molecular ultracold plasma
Double-resonant photoexcitation of nitric oxide in a molecular beam creates a
dense ensemble of Rydberg states, which evolves to form a plasma of
free electrons trapped in the potential well of an NO spacecharge. The
plasma travels at the velocity of the molecular beam, and, on passing through a
grounded grid, yields an electron time-of-flight signal that gauges the plasma
size and quantity of trapped electrons. This plasma expands at a rate that fits
with an electron temperature as low as 5 K, colder that typically observed for
atomic ultracold plasmas. The recombination of molecular NO cations with
electrons forms neutral molecules excited by more than twice the energy of the
NO chemical bond, and the question arises whether neutral fragmentation plays a
role in shaping the redistribution of energy and particle density that directs
the short-time evolution from Rydberg gas to plasma. To explore this question,
we adapt a coupled rate-equations model established for atomic ultracold
plasmas to describe the energy-grained avalanche of electron-Rydberg and
electron-ion collisions in our system. Adding channels of Rydberg
predissociation and two-body, electron- cation dissociative recombination to
the atomic formalism, we investigate the kinetics by which this relaxation
distributes particle density and energy over Rydberg states, free electrons and
neutral fragments. The results of this investigation suggest some mechanisms by
which molecular fragmentation channels can affect the state of the plasma
Stationary Localized States Due to a Nonlinear Dimeric Impurity Embedded in a Perfect 1-D Chain
The formation of Stationary Localized states due to a nonlinear dimeric
impurity embedded in a perfect 1-d chain is studied here using the appropriate
Discrete Nonlinear Schrdinger Equation. Furthermore, the nonlinearity
has the form, where is the complex amplitude. A proper
ansatz for the Localized state is introduced in the appropriate Hamiltonian of
the system to obtain the reduced effective Hamiltonian. The Hamiltonian
contains a parameter, which is the ratio of stationary
amplitudes at impurity sites. Relevant equations for Localized states are
obtained from the fixed point of the reduced dynamical system. = 1 is
always a permissible solution. We also find solutions for which . Complete phase diagram in the plane comprising of both
cases is discussed. Several critical lines separating various regions are
found. Maximum number of Localized states is found to be six. Furthermore, the
phase diagram continuously extrapolates from one region to the other. The
importance of our results in relation to solitonic solutions in a fully
nonlinear system is discussed.Comment: Seven figures are available on reques
Upper thermospheric ion-neutral coupling from combined optical and radar experiments over Svalbard
Optimal Investment-Consumption Problem with Constraint
In this paper, we consider an optimal investment-consumption problem subject to a closed convex constraint. In the problem, a constraint is imposed on both the investment and the consumption strategy, rather than just on the investment. The existence of solution is established by using the Martingale technique and convex duality. In addition to investment, our technique embeds also the consumption into a family of fictitious markets. However, with the addition of consumption, it leads to nonreflexive dual spaces. This difficulty is overcome by employing the so-called technique of \relaxation-projection" to establish the existence of solution to the problem. Furthermore, if the solution to the dual problem is obtained, then the solution to the primal problem can be found by using the characterization of the solution. An illustrative example is given with a dynamic risk constraint to demonstrate the method
Optimization of a high work function solution processed vanadium oxide hole-extracting layer for small molecule and polymer organic photovoltaic cells
We report a method of fabricating a high work function, solution processable vanadium oxide (V2Ox(sol)) hole-extracting layer. The atmospheric processing conditions of film preparation have a critical influence on the electronic structure and stoichiometry of the V2Ox(sol), with a direct impact on organic photovoltaic (OPV) cell performance. Combined Kelvin probe (KP) and ultraviolet photoemission spectroscopy (UPS) measurements reveal a high work function, n-type character for the thin films, analogous to previously reported thermally evaporated transition metal oxides. Additional states within the band gap of V2Ox(sol) are observed in the UPS spectra and are demonstrated using X-ray photoelectron spectroscopy (XPS) to be due to the substoichiometric nature of V2Ox(sol). The optimized V2Ox(sol) layer performance is compared directly to bare indium–tin oxide (ITO), poly(ethyleneoxythiophene):poly(styrenesulfonate) (PEDOT:PSS), and thermally evaporated molybdenum oxide (MoOx) interfaces in both small molecule/fullerene and polymer/fullerene structures. OPV cells incorporating V2Ox(sol) are reported to achieve favorable initial cell performance and cell stability attributes
A Study of The Formation of Stationary Localized States Due to Nonlinear Impurities Using The Discrete Nonlinear Schr\"odinger Equation
The Discrete Nonlinear Schrdinger Equation is used to study the
formation of stationary localized states due to a single nonlinear impurity in
a Caley tree and a dimeric nonlinear impurity in the one dimensional system.
The rotational nonlinear impurity and the impurity of the form where is arbitrary and is the nonlinearity
parameter are considered. Furthermore, represents the absolute
value of the amplitude. Altogether four cases are studies. The usual Greens
function approach and the ansatz approach are coherently blended to obtain
phase diagrams showing regions of different number of states in the parameter
space. Equations of critical lines separating various regions in phase diagrams
are derived analytically. For the dimeric problem with the impurity , three values of , namely, , at and and
for are obtained. Last two values are lower than the
existing values. Energy of the states as a function of parameters is also
obtained. A model derivation for the impurities is presented. The implication
of our results in relation to disordered systems comprising of nonlinear
impurities and perfect sites is discussed.Comment: 10 figures available on reques
Clinical course, therapeutic responses and outcomes in relapsing MOG antibody-associated demyelination.
Abstract
OBJECTIVE:
We characterised the clinical course, treatment and outcomes in 59 patients with relapsing myelin oligodendrocyte glycoprotein (MOG) antibody-associated demyelination.
METHODS:
We evaluated clinical phenotypes, annualised relapse rates (ARR) prior and on immunotherapy and Expanded Disability Status Scale (EDSS), in 218 demyelinating episodes from 33 paediatric and 26 adult patients.
RESULTS:
The most common initial presentation in the cohort was optic neuritis (ON) in 54% (bilateral (BON) 32%, unilateral (UON) 22%), followed by acute disseminated encephalomyelitis (ADEM) (20%), which occurred exclusively in children. ON was the dominant phenotype (UON 35%, BON 19%) of all clinical episodes. 109/226 (48%) MRIs had no brain lesions. Patients were steroid responsive, but 70% of episodes treated with oral prednisone relapsed, particularly at doses <10\u2009mg daily or within 2 months of cessation. Immunotherapy, including maintenance prednisone (P=0.0004), intravenous immunoglobulin, rituximab and mycophenolate, all reduced median ARRs on-treatment. Treatment failure rates were lower in patients on maintenance steroids (5%) compared with non-steroidal maintenance immunotherapy (38%) (P=0.016). 58% of patients experienced residual disability (average follow-up 61 months, visual loss in 24%). Patients with ON were less likely to have sustained disability defined by a final EDSS of 652 (OR 0.15, P=0.032), while those who had any myelitis were more likely to have sustained residual deficits (OR 3.56, P=0.077).
CONCLUSION:
Relapsing MOG antibody-associated demyelination is strongly associated with ON across all age groups and ADEM in children. Patients are highly responsive to steroids, but vulnerable to relapse on steroid reduction and cessation
Infliximab is associated with an increased risk of serious infection in patients with psoriasis in the UK and Republic of Ireland: results from the British Association of Dermatologists Biologic Interventions Register (BADBIR)
Risk mitigating behaviours in people with inflammatory skin and joint disease during the COVID-19 pandemic differ by treatment type:a cross-sectional patient survey
BACKGROUND: Registry data suggest that people with immune-mediated inflammatory diseases (IMIDs) receiving targeted systemic therapies have fewer adverse coronavirus disease 2019 (COVID-19) outcomes compared with patients receiving no systemic treatments. OBJECTIVES: We used international patient survey data to explore the hypothesis that greater risk-mitigating behaviour in those receiving targeted therapies may account, at least in part, for this observation. METHODS: Online surveys were completed by individuals with psoriasis (globally) or rheumatic and musculoskeletal diseases (RMDs) (UK only) between 4 May and 7 September 2020. We used multiple logistic regression to assess the association between treatment type and risk-mitigating behaviour, adjusting for clinical and demographic characteristics. We characterized international variation in a mixed-effects model. RESULTS: Of 3720 participants (2869 psoriasis, 851 RMDs) from 74 countries, 2262 (60·8%) reported the most stringent risk-mitigating behaviour (classified here under the umbrella term 'shielding'). A greater proportion of those receiving targeted therapies (biologics and Janus Kinase inhibitors) reported shielding compared with those receiving no systemic therapy [adjusted odds ratio (OR) 1·63, 95% confidence interval (CI) 1·35-1·97]. The association between targeted therapy and shielding was preserved when standard systemic therapy was used as the reference group (OR 1·39, 95% CI 1·23-1·56). Shielding was associated with established risk factors for severe COVID-19 [male sex (OR 1·14, 95% CI 1·05-1·24), obesity (OR 1·37, 95% CI 1·23-1·54), comorbidity burden (OR 1·43, 95% CI 1·15-1·78)], a primary indication of RMDs (OR 1·37, 95% CI 1·27-1·48) and a positive anxiety or depression screen (OR 1·57, 95% CI 1·36-1·80). Modest differences in the proportion shielding were observed across nations. CONCLUSIONS: Greater risk-mitigating behaviour among people with IMIDs receiving targeted therapies may contribute to the reported lower risk of adverse COVID-19 outcomes. The behaviour variation across treatment groups, IMIDs and nations reinforces the need for clear evidence-based patient communication on risk-mitigation strategies and may help inform updated public health guidelines as the pandemic continues
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