Remarques sur l'évolution de la responsabilité civile délictuelle en droit allemand

Weitnauer H. Remarques sur l'évolution de la responsabilité civile délictuelle en droit allemand. In: Revue internationale de droit comparé. Vol. 19 N°4, Octobre-décembre 1967. pp. 807-826

Comparison of Microbiomes from Different Niches of Upper and Lower Airways in Children and Adolescents with Cystic Fibrosis

Changes in the airway microbiome may be important in the pathophysiology of chronic lung disease in patients with cystic fibrosis. However, little is known about the microbiome in early cystic fibrosis lung disease and the relationship between the microbiomes from different niches in the upper and lower airways. Therefore, in this cross-sectional study, we examined the relationship between the microbiome in the upper (nose and throat) and lower (sputum) airways from children with cystic fibrosis using next generation sequencing. Our results demonstrate a significant difference in both α and β-diversity between the nose and the two other sampling sites. The nasal microbiome was characterized by a polymicrobial community while the throat and sputum communities were less diverse and dominated by a few operational taxonomic units. Moreover, sputum and throat microbiomes were closely related especially in patients with clinically stable lung disease. There was a high inter-individual variability in sputum samples primarily due to a decrease in evenness linked to increased abundance of potential respiratory pathogens such as Pseudomonas aeruginosa. Patients with chronic Pseudomonas aeruginosa infection exhibited a less diverse sputum microbiome. A high concordance was found between pediatric and adult sputum microbiomes except that Burkholderia was only observed in the adult cohort. These results indicate that an adult-like lower airways microbiome is established early in life and that throat swabs may be a good surrogate in clinically stable children with cystic fibrosis without chronic Pseudomonas aeruginosa infection in whom sputum sampling is often not feasible

Entropy-based Correction of Eye Tracking Data for Static Scenes

John S, Weitnauer E, Koesling H. Entropy-based Correction of Eye Tracking Data for Static Scenes. In: Morimoto CH, Istance H, Spencer SN, Association for Computing Machinery, eds. ETRA 2012 ACM Symposium on Eye-Tracking Research \textbackslash& Applications. ACM Digital Library. New York, USA: ACM; 2012: 297-300.In a typical head-mounted eye tracking system, any small slippage of the eye tracker headband on the participant\textbackslashtextquoteright}s head leads to a systematic error in the recorded gaze positions. While various approaches exist that reduce these errors at recording time, only few methods reduce the errors of a given tracking system after recording. In this paper we introduce a novel correction algorithm that can significantly reduce the drift in recorded gaze data for eye tracking experiments that use static stimuli. The algorithm is entropy-based and needs no prior knowledge about the stimuli shown or the tasks participants accomplish during the experiment

Supplementary Material for: Endoplasmic Reticulum Stress Is a Danger Signal Promoting Innate Inflammatory Responses in Bronchial Epithelial Cells

Endoplasmic reticulum (ER) stress is associated with chronic pulmonary inflammatory diseases. We hypothesized that the combined activation of both Toll-like receptor (TLR) signaling and ER stress might increase inflammatory reactions in otherwise tolerant airway epithelial cells. Indeed, ER stress resulted in an increased response of BEAS-2B and human primary bronchial epithelial cells to pathogen-associated molecular pattern stimulation with respect to IL6 and IL8 production. ER stress elevated p38 and ERK MAP kinase activation, and pharmacological inhibition of these kinases could inhibit the boosting effect. Knockdown of unfolded protein response signaling indicated that mainly PERK and ATF6 were responsible for the synergistic activity. Specifically, PERK and ATF6 mediated increased MAPK activation, which is needed for effective cytokine secretion. We conclude that within airway epithelial cells the combined activation of TLR signaling and ER stress-mediated MAPK activation results in synergistic proinflammatory activity. We speculate that ER stress, present in various chronic pulmonary diseases, boosts TLR signaling and therefore proinflammatory cytokine production, thus acting as a costimulatory danger signal

Consistency of spatio-temporal patterns of avian migration across the Swiss lowlands

Each year, billions of birds migrate across the continents by day and night through airspaces increasingly altered by human activity, resulting in the deaths of millions of birds every year through collisions with man‐made structures. To reduce these negative impacts on wildlife, forecasts of high migration intensities are needed to apply mitigation actions. While existing weather radar networks offer a unique possibility to monitor and forecast bird migration at large spatial scales, forecasts at the fine spatial scale within a complex terrain, such as the mountainous Swiss landscape, require a small‐scale network of ornithological radars. Before attempting to build such a network, it is crucial to first investigate the consistency of the migratory flow across space and time. In this study, we simultaneously operated three ornithological radar systems across the Swiss lowlands to assess the spatio‐temporal consistency of diurnal and nocturnal bird movements during the spring and autumn migration season. The relative temporal course of migration intensities was generally consistent between sites during peak migration, in particular for nocturnal movements in autumn, but absolute intensities differed greatly between sites. Outside peak migration, bird movement patterns were much less consistent and, unexpectedly, some presumably non‐migratory bird activity achieved intensities close to peak migration intensities, but without spatial correlations. Only nocturnal migration intensity in autumn could be predicted with consistently high accuracy, but including parameters of atmospheric conditions in the model improved predictability of diurnal movements considerably. Predictions for spring were less reliable, probably because we missed an important part of the migration season. Our results show that reliable forecasts of bird movements within a complex terrain call for a network of year‐round bird monitoring systems, whereas accurate information of atmospheric conditions can help to limit the number of measurement points