380 research outputs found
The Univariate Marginal Distribution Algorithm Copes Well With Deception and Epistasis
In their recent work, Lehre and Nguyen (FOGA 2019) show that the univariate
marginal distribution algorithm (UMDA) needs time exponential in the parent
populations size to optimize the DeceptiveLeadingBlocks (DLB) problem. They
conclude from this result that univariate EDAs have difficulties with deception
and epistasis.
In this work, we show that this negative finding is caused by an unfortunate
choice of the parameters of the UMDA. When the population sizes are chosen
large enough to prevent genetic drift, then the UMDA optimizes the DLB problem
with high probability with at most fitness
evaluations. Since an offspring population size of order
can prevent genetic drift, the UMDA can solve the DLB problem with fitness evaluations. In contrast, for classic evolutionary algorithms no
better run time guarantee than is known (which we prove to be tight
for the EA), so our result rather suggests that the UMDA can cope
well with deception and epistatis.
From a broader perspective, our result shows that the UMDA can cope better
with local optima than evolutionary algorithms; such a result was previously
known only for the compact genetic algorithm. Together with the lower bound of
Lehre and Nguyen, our result for the first time rigorously proves that running
EDAs in the regime with genetic drift can lead to drastic performance losses
Distributed Synthesis in Continuous Time
We introduce a formalism modelling communication of distributed agents
strictly in continuous-time. Within this framework, we study the problem of
synthesising local strategies for individual agents such that a specified set
of goal states is reached, or reached with at least a given probability. The
flow of time is modelled explicitly based on continuous-time randomness, with
two natural implications: First, the non-determinism stemming from interleaving
disappears. Second, when we restrict to a subclass of non-urgent models, the
quantitative value problem for two players can be solved in EXPTIME. Indeed,
the explicit continuous time enables players to communicate their states by
delaying synchronisation (which is unrestricted for non-urgent models). In
general, the problems are undecidable already for two players in the
quantitative case and three players in the qualitative case. The qualitative
undecidability is shown by a reduction to decentralized POMDPs for which we
provide the strongest (and rather surprising) undecidability result so far
Solution Synthesis and Characterization of a Long and Curved Graphene Nanoribbon with Hybrid Cove–Armchair–Gulf Edge Structures
Dedicated to Professor Klaus Müllen on the occasion of his 75th birthday
Post-colonoscopy colorectal cancers in a national FIT-based CRC screening program
Background and study aims: Post-colonoscopy colorectal cancers (PCCRCs) decrease the effect of colorectal cancer (CRC) screening programs. To enable PCCRC incidence reduction on the long-term we classified PCCRCs diagnosed after colonoscopies performed in a fecal immunochemical test (FIT-) based screening program. Patients and methods: PCCRCs diagnosed after colonoscopies performed between 2014-2016 for positive FIT in the Dutch CRC screening program were included. PCCRCs were categorized according to the World Endoscopy Organization consensus statement into a) interval PCCRC (diagnosed before the recommended surveillance), b) non-interval-type-A (diagnosed at the recommended surveillance interval), c) non-interval-type-B (diagnosed after the recommended surveillance interval), or d) non-interval-type-C (diagnosed after the intended recommended surveillance interval, but not applied due to comorbidity). The most probable etiology was determined by root-cause analysis. Tumor stage distributions were compared between categories. Results: 116,362 colonoscopies were performed after positive FIT with 9,978 screen-detected CRCs. During follow-up, 432 PCCRCs were diagnosed. The 3-year PCCRC rate was 2.7%. PCCRCs were categorized as interval (53.5%), non-interval-type-A (14.6%), non-interval-type-B (30.6%), and non-interval-type-C (1.4%). Interval PCCRCs had as most common etiology a possible missed lesion with adequate examination (73.6%) and were more often diagnosed at an advanced stage (stage III/IV, 53.2%) compared to non-interval-type-A (15.9%, p<0.001) and non-interval-type-B (40.9%, p=0.025) PCCRCs. Conclusions: The 3-year PCCRC rate was low in this FIT-based CRC screening program. Approximately half of PCCRCs were interval PCCRCs. These were mostly caused by missed lesions and were diagnosed at more advanced stage. This emphasizes the importance of high-quality colonoscopy with optimal polyp detection.</p
Neutron Diffraction Measurement of As-Cast Residual Stresses in Aa7050 Rolling Plate Ingots: Influence of A Wiper
During casting, thermally induced deformations give birth to ingot distortions and residual stresses. For some high strength alloys, ingot cracking can happen during casting per se or during cooling down. Ingot distortions such as rolling face pull-in, but curl and but swell are rather easy to quantify as opposed to internal stresses. As aluminium is rather transparent to neutrons, residual stress measurements using neutron diffraction appeared to be a good way to validate the thermomechanical models aimed at simulating the stress build-up during casting. This technique has been applied to DC cast AA7050 rolling plate ingots with special attention to the stress generation in the transient start-up phase, i.e. in the foot of the ingot. Additional results using the hole drilling method complement the measurements. The measured stress distributions are compared with the results of a numerical model of DC casting for ingots cast with and without a wiper
Post-Newtonian approximation for isolated systems calculated by matched asymptotic expansions
Two long-standing problems with the post-Newtonian approximation for isolated
slowly-moving systems in general relativity are: (i) the appearance at high
post-Newtonian orders of divergent Poisson integrals, casting a doubt on the
soundness of the post-Newtonian series; (ii) the domain of validity of the
approximation which is limited to the near-zone of the source, and prevents
one, a priori, from incorporating the condition of no-incoming radiation, to be
imposed at past null infinity. In this article, we resolve the problem (i) by
iterating the post-Newtonian hierarchy of equations by means of a new
(Poisson-type) integral operator that is free of divergencies, and the problem
(ii) by matching the post-Newtonian near-zone field to the exterior field of
the source, known from previous work as a multipolar-post-Minkowskian expansion
satisfying the relevant boundary conditions at infinity. As a result, we obtain
an algorithm for iterating the post-Newtonian series up to any order, and we
determine the terms, present in the post-Newtonian field, that are associated
with the gravitational-radiation reaction onto an isolated slowly-moving matter
system.Comment: 61 pages, to appear in Phys. Rev.
Relativistic Celestial Mechanics with PPN Parameters
Starting from the global parametrized post-Newtonian (PPN) reference system
with two PPN parameters and we consider a space-bounded
subsystem of matter and construct a local reference system for that subsystem
in which the influence of external masses reduces to tidal effects. Both the
metric tensor of the local PPN reference system in the first post-Newtonian
approximation as well as the coordinate transformations between the global PPN
reference system and the local one are constructed in explicit form. The terms
proportional to reflecting a violation of the
equivalence principle are discussed in detail. We suggest an empirical
definition of multipole moments which are intended to play the same role in PPN
celestial mechanics as the Blanchet-Damour moments in General Relativity.
Starting with the metric tensor in the local PPN reference system we derive
translational equations of motion of a test particle in that system. The
translational and rotational equations of motion for center of mass and spin of
each of extended massive bodies possessing arbitrary multipole structure
are derived. As an application of the general equations of motion a
monopole-spin dipole model is considered and the known PPN equations of motion
of mass monopoles with spins are rederived.Comment: 71 page
Serotonin and corticosterone rhythms in mice exposed to cigarette smoke and in patients with COPD:implication for COPD-associated neuropathogenesis
The circadian timing system controls daily rhythms of physiology and behavior, and disruption of clock function can trigger stressful life events. Daily exposure to cigarette smoke (CS) can lead to alteration in diverse biological and physiological processes. Smoking is associated with mood disorders, including depression and anxiety. Patients with chronic obstructive pulmonary disease (COPD) have abnormal circadian rhythms, reflected by daily changes in respiratory symptoms and lung function. Corticosterone (CORT) is an adrenal steroid that plays a considerable role in stress and anti-inflammatory responses. Serotonin (5-hydroxytryptamine; 5HT) is a neurohormone, which plays a role in sleep/wake regulation and affective disorders. Secretion of stress hormones (CORT and 5HT) is under the control of the circadian clock in the suprachiasmatic nucleus. Since smoking is a contributing factor in the development of COPD, we hypothesize that CS can affect circadian rhythms of CORT and 5HT secretion leading to sleep and mood disorders in smokers and patients with COPD. We measured the daily rhythms of plasma CORT and 5HT in mice following acute (3 d), sub-chronic (10 d) or chronic (6 mo) CS exposure and in plasma from non-smokers, smokers and patients with COPD. Acute and chronic CS exposure affected both the timing (peak phase) and amplitude of the daily rhythm of plasma CORT and 5HT in mice. Acute CS appeared to have subtle time-dependent effects on CORT levels but more pronounced effects on 5HT. As compared with CORT, plasma 5HT was slightly elevated in smokers but was reduced in patients with COPD. Thus, the effects of CS on plasma 5HT were consistent between mice and patients with COPD. Together, these data reveal a significant impact of CS exposure on rhythms of stress hormone secretion and subsequent detrimental effects on cognitive function, depression-like behavior, mood/anxiety and sleep quality in smokers and patients with COPD
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