102 research outputs found
Positivity of relative canonical bundles and applications
Given a family of canonically polarized manifolds, the
unique K\"ahler-Einstein metrics on the fibers induce a hermitian metric on the
relative canonical bundle . We use a global elliptic
equation to show that this metric is strictly positive on , unless
the family is infinitesimally trivial.
For degenerating families we show that the curvature form on the total space
can be extended as a (semi-)positive closed current. By fiber integration it
follows that the generalized Weil-Petersson form on the base possesses an
extension as a positive current. We prove an extension theorem for hermitian
line bundles, whose curvature forms have this property. This theorem can be
applied to a determinant line bundle associated to the relative canonical
bundle on the total space. As an application the quasi-projectivity of the
moduli space of canonically polarized varieties
follows.
The direct images , , carry natural hermitian metrics. We prove an
explicit formula for the curvature tensor of these direct images. We apply it
to the morphisms that are induced by the Kodaira-Spencer map and obtain a differential
geometric proof for hyperbolicity properties of .Comment: Supercedes arXiv:0808.3259v4 and arXiv:1002.4858v2. To appear in
Invent. mat
Differential Forms on Log Canonical Spaces
The present paper is concerned with differential forms on log canonical
varieties. It is shown that any p-form defined on the smooth locus of a variety
with canonical or klt singularities extends regularly to any resolution of
singularities. In fact, a much more general theorem for log canonical pairs is
established. The proof relies on vanishing theorems for log canonical varieties
and on methods of the minimal model program. In addition, a theory of
differential forms on dlt pairs is developed. It is shown that many of the
fundamental theorems and techniques known for sheaves of logarithmic
differentials on smooth varieties also hold in the dlt setting.
Immediate applications include the existence of a pull-back map for reflexive
differentials, generalisations of Bogomolov-Sommese type vanishing results, and
a positive answer to the Lipman-Zariski conjecture for klt spaces.Comment: 72 pages, 6 figures. A shortened version of this paper has appeared
in Publications math\'ematiques de l'IH\'ES. The final publication is
available at http://www.springerlink.co
Anti-Pluricanonical Systems On Q-Fano Threefolds
We investigate birationality of the anti-pluricanonical map , the
rational map defined by the anti-pluricanonical system , on
-Fano threefolds.Comment: 18 page
Finite Generation of Canonical Ring by Analytic Method
In the 80th birthday conference for Professor LU Qikeng in June 2006 I gave a
talk on the analytic approach to the finite generation of the canonical ring
for a compact complex algebraic manifold of general type. This article is my
contribution to the proceedings of that conference from my talk. In this
article I give an overview of the analytic proof and focus on explaining how
the analytic method handles the problem of infinite number of interminable
blow-ups in the intuitive approach to prove the finite generation of the
canonical ring. The proceedings of the LU Qikeng conference will appear as
Issue No. 4 of Volume 51 of Science in China Series A: Mathematics
(www.springer.com/math/applications/journal/11425)
Overdiagnosis and overtreatment of breast cancer: Is overdiagnosis an issue for radiologists?
Overdiagnosis is diagnosis of cancers that would not present within the life of the patient and is one of the downsides of screening. This applies to low-grade ductal carcinoma in situ and some small grade 1 invasive cancers. Radiologists are responsible for cancer diagnosis, but at the time of diagnosis they cannot determine whether a particular low-grade diagnosis is one to which the definition of overdiagnosis applies. Overdiagnosis is likely to be driven by technological developments, including digital mammography, computer-aided detection and improved biopsy techniques. It is also driven by the patient's fear that cancer will be missed and the doctor's fear of litigation. It is therefore an issue of importance for radiologists, presenting them with difficult fine-tuned decisions in every assessment clinic that are ultimately counted later by those who evaluate their screening
Carbonate-Templated Self-Assembly of an Alkylthiolate-Bridged Cadmium Macrocycle
In the presence of Cd(ClO4)2 and a base, a new mixed N,S-donor alkylthiolate ligand supported both carbonate formation from atmospheric CO2 and the self-assembly of a novel bicapped puckered (CdS)6 molecular wheel. The remarkable stability of the complex was demonstrated by slow intermolecular ligand exchange on the 2J(HH) and J(111/113Cd1H) time scales at elevated temperature. Both CO2 and the base were required to convert amorphous “CdLClO4” precipitated in the absence of air to the carbonate complex. The complex shares structural features with the ζ-carbonic anhydrase class associating cadmium(II) with the biogeochemical cycling of carbon and is the first structurally characterized carbonate complex of any metal involving an alkylthiolate ligand
Magnetic resonance mammography in the evaluation of recurrence at the prior lumpectomy site after conservative surgery and radiotherapy
INTRODUCTION: The aim was to assess the value of magnetic resonance mammography (MRM) in the detection of recurrent breast cancer on the prior lumpectomy site in patients with previous conservative surgery and radiotherapy. METHODS: Between April 1999 and July 2003, 93 consecutive patients with breast cancer treated with conservative surgery and radiotherapy underwent MRM, when a malignant lesion on the site of lumpectomy was suspected by ultrasound and/or mammography. MRM scans were evaluated by morphological and dynamic characteristics. MRM diagnosis was compared with histology or with a 36-month imaging follow-up. Enhancing areas independent of the prior lumpectomy site, incidentally detected during the MRM, were also evaluated. RESULTS: MRM findings were compared with histology in 29 patients and with a 36-month follow-up in 64 patients. MRM showed 90% sensitivity, 91.6% specificity, 56.3% positive predictive value and 98.7% negative predictive value for detection of recurrence on the surgical scar. MRM detected 13 lesions remote from the scar. The overall sensitivity, specificity, positive predictive value and negative predictive value of MRM for detection of breast malignancy were 93.8%, 90%, 62.5% and 98.8%, respectively. CONCLUSION: MRM is a sensitive method to differentiate recurrence from post-treatment changes at the prior lumpectomy site after conservative surgery and radiation therapy. The high negative predictive value of this technique can avoid unnecessary biopsies or surgical treatments
Breast MRI: guidelines from the European Society of Breast Imaging
The aim of breast MRI is to obtain a reliable evaluation of any lesion within the breast. It is currently always used as an adjunct to the standard diagnostic procedures of the breast, i.e., clinical examination, mammography and ultrasound. Whereas the sensitivity of breast MRI is usually very high, specificity—as in all breast imaging modalities—depends on many factors such as reader expertise, use of adequate techniques and composition of the patient cohorts. Since breast MRI will always yield MR-only visible questionable lesions that require an MR-guided intervention for clarification, MRI should only be offered by institutions that can also offer a MRI-guided breast biopsy or that are in close contact with a site that can perform this type of biopsy for them. Radiologists involved in breast imaging should ensure that they have a thorough knowledge of the MRI techniques that are necessary for breast imaging, that they know how to evaluate a breast MRI using the ACR BI-RADS MRI lexicon, and most important, when to perform breast MRI. This manuscript provides guidelines on the current best practice for the use of breast MRI, and the methods to be used, from the European Society of Breast Imaging (EUSOBI)
Role of magnetic resonance imaging in the planning of breast cancer treatment strategies: comparison with conventional imaging techniques
Bilateral breast cancer: analysis of incidence, outcome, survival and disease characteristics
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