IN VITRO ANTIOXIDANT, ANTIMICROBIAL AND ADMET STUDY OF NOVEL FURAN/BENZOFURAN C-2 COUPLED QUINOLINE HYBRIDS

Objectives: Synthesis of novel 2-(benzofuran-2-yl) and 2-(furan-2-yl) quinoline-4- carboxylates and their [2-(1-benzofuran-2-yl) quinolin-4-yl] methanol, [2-(1-furan-2-yl) quinolin-4-yl] methanol and its derivatives for antioxidant, antimicrobial and ADMET study.Methods: Synthesis was carried with conventional method and the structures were confirmed by IR, 1H NMR, 13C NMR and mass spectral analysis. The antioxidant activity was performed by DPPH and H2O2 radical scavenging method. Antimicrobial investigation was established by cup plate and food poison technique. The in silico absorption, distribution, metabolism, excretion and toxicity (ADMET) study of the drug was carried out in ACD/lab-2.Results: The antioxidant activity results revealed that, compounds 4b-c, 5a-b, 10c and 10f exhibited good DPPH radical and hydrogen peroxide scavenging activity. The antibacterial results revealed that, compounds 4c, 5a-b, 10b, 10d and 10f exhibited good activity against Escherichia coli, Klebsiella pneumonia and Salmonella typhimurium. Further, the antifungal activity results showed that, compounds 4c, 5c and 10c-e were showing good activity against Aspergillus flavus and Candida neoformans.  The mean value of P<0.05 were considered to be statistically significant. The ADMET results revealed that compounds emerged as a potential candidate for antioxidant and antimicrobial agents.Conclusion: The study reveals that compounds containing furan/benzofuran coupled heterocycles are play the important role for activity as they possess potent antioxidant and antimicrobial agents. The in silico ADME analysis also suggesting the compounds were in acceptable range to obey the pharmacokinetic parameters.Â

Partial uterine perforation and ovarian embedment of misplaced intrauterine device: a case report

Intrauterine devices (IUDs) are the commonest form of contraceptive method in use globally. IUDs like other methods of contraception may be associated with its own complications. The major risk includes uterine perforation with embedment, migration, and/or expulsion. A 35 year old female who had a history of postpartum IUD insertion 10 years ago was referred to our institute with complains of severe lower abdominal pain and vomiting since 10 days. Transabdominal and transvaginal ultrasound (TAS/TVS) were done. Ultrasound led to the final diagnosis of ovarian embedment of the IUD. Laparotomy with IUD removal was successfully performed. This case report highlights one of the rare complications of IUD migrating to the left ovary in a patient presenting with lower abdominal pain. In a patient with history an IUD insertion in situ, lower abdominal pain and missing threads on examination should wary the gynaecologist to the possibility of total or partial transmigration of the device into the pelvis or abdomen

Zero Order Spectrophotometric Method for Estimation of Escitalopram Oxalate in Tablet Formulations

A new, simple, fast and reliable zero order spectrophotometric method has been developed for determination of Escitalopram Oxalate in bulk and tablet dosage forms. The quantitative determination of drug was carried out using the zero order values (absorbance) measured at 238 nm. Calibration graph constructed at 238 nm was linear in concentration range of 2-20 µg/ml with correlation coefficient 0.9999. The method was found to be precise, accurate, specific, and validated as per ICH guidelines and can be used for determination of Escitalopram Oxalate in tablet formulations

Pearl Millet

Pearl millet [Pennisetum glaucum (L). R. Br.] is cultivated on more than 8 million ha in India, ranking third after rice and wheat in acreage. It is an important source of staple food for human beings and valuable source of fodder for livestock in marginal environments. A significant portion of pearl millet grain is also used for non-food purposes such as poultry and cattle feed and alcohol extraction. Pearl millet improvement research in India is coordinated through the All India Coordinated Pearl Millet Improvement Project (AICPMIP) under the aegis of Indian Council of Agricultural Research (ICAR). Enormous accomplishments have been made in pearl millet improvement during the last 25 years. This chapter presents an overview of achievements in genetic improvement, cultural practices, disease and insect-pest management, seed production and value addition. Germplasm from diverse genetic backgrounds and breeding materials with adequate disease resistance have been utilized in hybrid parental line breeding programmes leading towards development of hybrids with good adaptation to diverse production environments. During the last 25 years, a total of 115 improved cultivars were released, which provided a wider cultivar choice to farmers in various agro-ecological regions. Agronomic research led to the establishment of detailed recommendations for agroecology specific pearl millet zones which made it possible to harness the yield potential of high-yielding hybrids and varieties. High-yielding hybrids and open-pollinated varieties (OPVs) have been widely adopted by Indian farmers. Currently, nearly 65 % of pearl millet area is under improved cultivars, mainly hybrids. A genetic linkage map of pearl millet has been developed, and quantitative trait loci (QTL) have been identified for traits of economic importance to facilitate molecular marker-assisted selection. Several processing technologies have been standardized to popularize pearl millet-based traditional and health food products. In the future climate change scenario, pearl millet being a highly climate resilient crop will play a greater role in providing food and nutritional security

Deep Low-frequency Radio Observations of A2256. I. the Filamentary Radio Relic

We present deep and high-fidelity images of the merging galaxy cluster A2256 at low frequencies using the upgraded Giant Metrewave Radio Telescope (uGMRT) and LOw-Frequency ARray (LOFAR). This cluster hosts one of the most prominent known relics with a remarkably spectacular network of filamentary substructures. The new uGMRT (300-850 MHz) and LOFAR (120-169 MHz) observations, combined with the archival Karl G. Jansky Very Large Array (VLA; 1-4 GHz) data, allowed us to carry out the first spatially resolved spectral analysis of the exceptional relic emission down to 6″ resolution over a broad range of frequencies. Our new sensitive radio images confirm the presence of complex filaments of magnetized relativistic plasma also at low frequencies. We find that the integrated spectrum of the relic is consistent with a single power law, without any sign of spectral steepening, at least below 3 GHz. Unlike previous claims, the relic shows an integrated spectral index of -1.07 ± 0.02 between 144 MHz and 3 GHz, which is consistent with the (quasi)stationary shock approximation. The spatially resolved spectral analysis suggests that the relic surface very likely traces the complex shock front, with a broad distribution of Mach numbers propagating through a turbulent and dynamically active intracluster medium. Our results show that the northern part of the relic is seen edge-on and the southern part close to face-on. We suggest that the complex filaments are regions where higher Mach numbers dominate the (re)acceleration of electrons that are responsible for the observed radio emission

Radio spectral properties and jet duty cycle in the restarted radio galaxy 3C388

© ESO 2020. The original publication is available at https://doi.org/10.1051/0004-6361/202037457.Context. Restarted radio galaxies represent a unique tool for investigating the duty cycle of the jet activity in active galactic nuclei (AGN). The radio galaxy 3C388 has long been claimed to be a peculiar example of an AGN with multi-epoch activity because it shows a very sharp discontinuity in the GHz spectral index distribution of its lobes. Aims. We present here for the first time a spatially resolved study of the radio spectrum of 3C388 down to MHz frequencies aimed at investigating the radiative age of the source and constraining its duty cycle. Methods. We used new low-frequency observations at 144 MHz performed with the Low Frequency Array and at 350 MHz performed with the Very Large Array that we combined with archival data at higher frequencies (614, 1400, and 4850 MHz). Results. We find that the spectral indices in the lower frequency range, 144-614 MHz, have flatter values (αlow ∼0.55-1.14) than those observed in the higher frequency range, 1400-4850 MHz, (αhigh ∼0.75-1.57), but they follow the same distribution across the lobes, with a systematic steepening towards the edges. However, the spectral shape throughout the source is not uniform and often deviates from standard models. This suggests that mixing of different particle populations occurs, although it remains difficult to understand whether this is caused by observational limitations (insufficient spatial resolution and/or projection effects) or by the intrinsic presence of multiple particle populations, which might be related to the two different outbursts. Conclusions. Using single-injection radiative models, we compute that the total source age is ≲ 80 Myr and that the duty cycle is about ton/ttot ∼ 60%, which is enough to prevent the intracluster medium from cooling, according to X-ray estimates. While to date the radio spectral distribution of 3C388 remains a rare case among radio galaxies, multi-frequency surveys performed with new-generation instruments will soon allow us to investigate whether more sources with the same characteristics exist.Peer reviewe

Physical insights from the spectrum of the radio halo in MACS J0717.5+3745

We present new LOFAR observations of the massive merging galaxy cluster MACS J0717.5+3745. The cluster hosts the most powerful radio halo known to date. These new observations, in combination with published uGMRT (300$-$850 MHz) and VLA (1$-$6.5 GHz) data, reveal that the halo is more extended than previously thought, with a largest linear size of $\sim2.2 \rm Mpc$. The halo shows a steep spectrum ($\alpha_{144\,\text{MHz}}^{1.5\,\text{GHz}}\sim-1.4$) and a steepening ($\alpha_{1.5 \text{GHz}}^{5.5 \text{GHz}}\sim-1.9$) above 1.5 GHz. We find a strong scattering in spectral index maps on scales of 50$-$100 kpc. We suggest that such a strong scattering may be a consequence of the regime where inverse Compton dominate the energy losses of electrons. The spectral index becomes steeper and shows an increased curvature in the outermost regions of the halo. We combined the radio data with \textit{Chandra} observations to investigate the connection between the thermal and non-thermal components of the intracluster medium (ICM). Despite a significant substructure in the halo emission, the radio brightness correlates strongly with the X-ray brightness at all observed frequencies. The radio-versus-X-ray brightness correlation slope steepens at a higher radio frequency (from $b_{144 \text{MHz}}=0.67\pm0.05$ to $b_{3.0 \text{GHz}}=0.98\pm0.09$) and the spectral index shows a significant anti correlation with the X-ray brightness. Both pieces of evidence further support a spectral steepening in the external regions. The compelling evidence for a steep spectral index, the existence of a spectral break above 1.5 GHz, and the dependence of radio and X-ray surface brightness correlation on frequency are interpreted in the context of turbulent reacceleration models. Under this scenario, our results allowed us to constrain that the turbulent kinetic pressure of the ICM is up to 10%.Comment: 16 pages, 12 figures, accepted for publication in A&

Deep VLA Observations of the Cluster 1RXS J0603.3+4214 in the Frequency Range of 1–2 GHz

We report L-band VLA observations of 1RXS J0603.3+4214, a cluster that hosts a bright radio relic, known as the Toothbrush, and an elongated giant radio halo. These new observations allow us to study the surface brightness distribution down to one arcsec resolution with very high sensitivity. Our images provide an unprecedented detailed view of the Toothbrush, revealing enigmatic filamentary structures. To study the spectral index distribution, we complement our analysis with published LOFAR and GMRT observations. The bright `brush' of the Toothbrush shows a prominent narrow ridge to its north with a sharp outer edge. The spectral index at the ridge is in the range $-0.70\leq\alpha\leq-0.80$. We suggest that the ridge is caused by projection along the line of sight. With a simple toy model for the smallest region of the ridge, we conclude that the magnetic field is below $5\,\rm\mu G$ and varies significantly across the shock front. Our model indicates that the actual Mach number is higher than that obtained from the injection index and agrees well with the one derived from the overall spectrum, namely ${\cal M}=3.78^{+0.3}_{-0.2}$. The radio halo shows an average spectral index of $\alpha=-1.16\pm0.05$ and a slight gradient from north to south. The southernmost part of the halo is steeper and possibly related to a shock front. Excluding the southernmost part, the halo morphology agrees very well with the X-ray morphology. A power-law correlation is found between the radio and X-ray surface brightnessComment: 23 pages, 21 figures, accepted for publication in Ap

Physical insights from the spectrum of the radio halo in MACS J0717.5+3745

We present new LOw-Frequency ARray observations of the massive merging galaxy cluster MACS J0717.5+3745, located at a redshift of 0.5458. The cluster hosts the most powerful radio halo known to date. These new observations, in combination with published uGMRT (300-850 MHz) and VLA (1-6.5 GHz) data, reveal that the halo is more extended than previously thought, with a largest linear size of ∼2.2 Mpc, making it one of the largest known halos. The halo shows a steep spectrum (α144 MHz1.5 GHz ∼-1.4) and a steepening (α1.5 GHz5.5 GHz ∼-1.9) above 1.5 GHz. We find a strong scattering in spectral index maps on scales of 50-100 kpc. We suggest that such a strong scattering may be a consequence of the regime where inverse Compton dominates the energy losses of electrons. The spectral index becomes steeper and shows an increased curvature in the outermost regions of the halo. We combined the radio data with Chandra observations to investigate the connection between the thermal and nonthermal components of the intracluster medium (ICM). Despite a significant substructure in the halo emission, the radio brightness correlates strongly with the X-ray brightness at all observed frequencies. The radio-versus-X-ray brightness correlation slope steepens at a higher radio frequency (from b144? MHz? =? 0.67? ±? 0.05 to b3.0? GHz? =? 0.98? ±? 0.09) and the spectral index shows a significant anticorrelation with the X-ray brightness. Both pieces of evidence further support a spectral steepening in the external regions. The compelling evidence for a steep spectral index, the existence of a spectral break above 1.5 GHz, and the dependence of radio and X-ray surface brightness correlation on frequency are interpreted in the context of turbulent reacceleration models. Under this scenario, our results allowed us to constrain that the turbulent kinetic pressure of the ICM is up to 10%

Understanding the radio relic emission in the galaxy cluster MACS J0717.5+3745: Spectral analysis

Radio relics are diffuse, extended synchrotron sources that originate from shock fronts generated during cluster mergers. The massive merging galaxy cluster MACS J0717.5+3745 hosts one of the more complex relics known to date. We present upgraded Giant Metrewave Radio Telescope band 3 (300-500 MHz) and band 4 (550-850 MHz) observations. These new observations, combined with published VLA and the new LOFAR HBA data, allow us to carry out a detailed, high spatial resolution spectral analysis of the relic over a broad range of frequencies. The integrated spectrum of the relic closely follows a power law between 144 MHz and 5.5 GHz with a mean spectral slope αâ€., =â€., -1.16†±â€ 0.03. Despite the complex morphology of this relic, its subregions and the other isolated filaments also follow power-law behaviors, and show similar spectral slopes. Assuming diffusive shock acceleration, we estimated a dominant Mach number of ∼3.7 for the shocks that make up the relic. A comparison with recent numerical simulations suggests that in the case of radio relics, the slopes of the integrated radio spectra are determined by the Mach number of the accelerating shock, with α nearly constant, namely between -1.13 and -1.17, for Mach numbers 3.5†-†4.0. The spectral shapes inferred from spatially resolved regions show curvature, we speculate that the relic is inclined along the line of sight. The locus of points in the simulated color-color plots changes significantly with the relic viewing angle. We conclude that projection effects and inhomogeneities in the shock Mach number dominate the observed spectral properties of the relic in this complex system. Based on the new observations we raise the possibility that the relic and a narrow-angle-tailed radio galaxy are two different structures projected along the same line of sight