2,087 research outputs found
Workmen\u27s Compensation -- What Is the Range of Compensable Consequences of A Work-Related Injury?
A procedurålis emlékezet szerepe a testkép zavaraiban = The role of procedural memory in trouble of body picture
Az evĂ©szavarok egyik vezetĆ betegsĂ©gfenntartĂł tĂ©nyezĆje a betegek torzult, diszfunkcionĂĄlis kognĂciĂłja. Ezen belĂŒl is kiemelendĆk a tĂĄplĂĄlĂ©kfelvĂ©teli viselkedĂ©s zavaraival Ă©s a testĂ©lmĂ©nnyel kapcsolatban lĂ©vĆ, a zavarok lĂ©trejöttĂ©ben kulcsszerepet jĂĄtszĂł kognitĂv disztorziĂłk, melyek az informĂĄciĂłfeldolgozĂĄsi folyamatokon belĂŒl elsĆsorban a perceptuĂĄlis Ă©lmĂ©nyfeldolgozĂĄst Ă©rintik Ă©s evĂ©szavaros betegeknĂ©l a testkĂ©p speciĂĄlis zavarĂĄban mutatkoznak meg. A kognitĂv informĂĄciĂłfeldolgozĂĄst a sĂ©mĂĄk irĂĄnyĂtjĂĄk, amelyekben a selfrĆl valĂł komplex tudĂĄs szervezĆdik. A sĂ©mĂĄk procedurĂĄlis ismeretanyagot is hordoznak, Ășgy mint motoros kĂ©szsĂ©geket, szokĂĄsokat, szabĂĄlyokat, cĂ©lkĂ©pzeteket, döntĂ©shozatali stratĂ©giĂĄkat. Ezek alapjĂĄn felmerĂŒl, hogy az evĂ©szavarokra jellemzĆ viselkedĂ©ses rutincselekvĂ©sek, mint pĂ©ldĂĄul a diĂ©tĂĄzĂĄs, falĂĄsroham, önhĂĄnytatĂĄs a testkĂ©p sĂ©mĂĄjĂĄn belĂŒl procedurĂĄlis Ă©lmĂ©nyanyagkĂ©nt kĂłdolĂłdhat Ă©s a munkamemĂłriĂĄban automatikusan a többi explicit tudĂĄssal Ă©s emlĂ©kkel egyĂŒtt aktivĂĄlĂłdik. ElmĂ©leti ĂĄttekintĂ©sĂŒnkben ezeknek a prekognitĂv folyamatoknak keressĂŒk a helyĂ©t Ă©s szerepĂ©t az evĂ©szavaros betegekre jellemzĆ kognitĂv informĂĄciĂłfeldolgozĂĄsi jellegzetessĂ©gek kialakĂtĂĄsĂĄban
Quantum W-symmetry in AdS_3
It has recently been argued that, classically, massless higher spin theories
in AdS_3 have an enlarged W_N-symmetry as the algebra of asymptotic isometries.
In this note we provide evidence that this symmetry is realised
(perturbatively) in the quantum theory. We perform a one loop computation of
the fluctuations for a massless spin field around a thermal AdS_3
background. The resulting determinants are evaluated using the heat kernel
techniques of arXiv:0911.5085. The answer factorises holomorphically, and the
contributions from the various spin fields organise themselves into vacuum
characters of the W_N symmetry. For the case of the hs(1,1) theory consisting
of an infinite tower of massless higher spin particles, the resulting answer
can be simply expressed in terms of (two copies of) the MacMahon function.Comment: 23 pages; v2: References adde
Factors associated with disease progression in early-diagnosed pulmonary arterial hypertension associated with systemic sclerosis: longitudinal data from the DETECT cohort
OBJECTIVE: Pulmonary arterial hypertension (PAH) is a severe complication of systemic sclerosis (SSc). In this longitudinal study, we aimed to identify factors associated with an unfavourable outcome in patients with SSc with early PAH (SSc-PAH) from the DETECT cohort. METHODS: Patients with SSc-PAH enrolled in DETECT were observed for up to 3 years. Associations between cross-sectional variables and disease progression (defined as the occurrence of any of the following events: WHO Functional Class worsening, combination therapy for PAH, hospitalisation or death) were analysed by univariable logistic regression. RESULTS: Of 57 patients with PAH (median observation time 12.6 months), 25 (43.9%) had disease progression. The following factors (OR (95% CI)) were associated with disease progression: male gender (4.1 (1.2 to 14.1)), high forced vital capacity % predicted/carbon monoxide lung diffusion capacity (DLCO)% predicted ratio (3.6 (1.2 to 10.7)), high Borg Dyspnoea Index (1.7 (1.1 to 2.6)) and low DLCO% predicted (non-linear relationship). CONCLUSION: More than 40% of early-diagnosed patients with SSc-PAH had disease progression during a short follow-up time, with male gender, functional capacity and pulmonary function tests at PAH diagnosis being associated with progression. This suggests that even mild PAH should be considered a high-risk complication of SSc
The aetiology and trajectory of anabolic-androgenic steroid use initiation: a systematic review and synthesis of qualitative research
Multi-organ damage induced by anabolic steroid supplements: a case report and literature review
Controlled human exposures to ambient pollutant particles in susceptible populations
Epidemiologic studies have established an association between exposures to air pollution particles and human mortality and morbidity at concentrations of particles currently found in major metropolitan areas. The adverse effects of pollution particles are most prominent in susceptible subjects, including the elderly and patients with cardiopulmonary diseases. Controlled human exposure studies have been used to confirm the causal relationship between pollution particle exposure and adverse health effects. Earlier studies enrolled mostly young healthy subjects and have largely confirmed the capability of particles to cause adverse health effects shown in epidemiological studies. In the last few years, more studies involving susceptible populations have been published. These recent studies in susceptible populations, however, have shown that the adverse responses to particles appear diminished in these susceptible subjects compared to those in healthy subjects. The present paper reviewed and compared control human exposure studies to particles and sought to explain the "unexpected" response to particle exposure in these susceptible populations and make recommendations for future studies. We found that the causes for the discrepant results are likely multifactorial. Factors such as medications, the disease itself, genetic susceptibility, subject selection bias that is intrinsic to many controlled exposure studies and nonspecificity of study endpoints may explain part of the results. Future controlled exposure studies should select endpoints that are more closely related to the pathogenesis of the disease and reflect the severity of particle-induced health effects in the specific populations under investigation. Future studies should also attempt to control for medications and genetic susceptibility. Using a different study design, such as exposing subjects to filtered air and ambient levels of particles, and assessing the improvement in biological endpoints during filtered air exposure, may allow the inclusion of higher risk patients who are likely the main contributors to the increased particle-induced health effects in epidemiological studies
New Therapeutic Strategies for Systemic Sclerosisâa Critical Analysis of the Literature
Systemic sclerosis (SSc) is a multi-system disease characterized by skin
fibrosis and visceral disease. Therapy is organ and pathogenesis targeted. In
this review, we describe novel strategies in the treatment of SSc. Utilizing the
MEDLINE and the COCHRANE REGISTRY, we identified open trials, controlled
trials, for treatment of SSc from 1999 to April 2005. We used the terms scleroderma,
systemic sclerosis, Raynaud's phenomenon, pulmonary hypertension,
methotrexate, cyclosporin, tacrolimus, relaxin, low-dose penicillamine, IVIg,
calcium channel blockers, losartan, prazocin, iloprost, N-acetylcysteine, bosentan,
cyclophosphamide, lung transplantation, ACE inhibitors,
anti-thymocyte globulin, and stem cell transplantation. Anecdotal reports were
omitted
Single Molecule Statistics and the Polynucleotide Unzipping Transition
We present an extensive theoretical investigation of the mechanical unzipping
of double-stranded DNA under the influence of an applied force. In the limit of
long polymers, there is a thermodynamic unzipping transition at a critical
force value of order 10 pN, with different critical behavior for homopolymers
and for random heteropolymers. We extend results on the disorder-averaged
behavior of DNA's with random sequences to the more experimentally accessible
problem of unzipping a single DNA molecule. As the applied force approaches the
critical value, the double-stranded DNA unravels in a series of discrete,
sequence-dependent steps that allow it to reach successively deeper energy
minima. Plots of extension versus force thus take the striking form of a series
of plateaus separated by sharp jumps. Similar qualitative features should
reappear in micromanipulation experiments on proteins and on folded RNA
molecules. Despite their unusual form, the extension versus force curves for
single molecules still reveal remnants of the disorder-averaged critical
behavior. Above the transition, the dynamics of the unzipping fork is related
to that of a particle diffusing in a random force field; anomalous,
disorder-dominated behavior is expected until the applied force exceeds the
critical value for unzipping by roughly 5 pN.Comment: 40 pages, 18 figure
The Naturalistic Flight Deck System: An Integrated System Concept for Improved Single-Pilot Operations
This paper reviews current and emerging operational experiences, technologies, and human-machine interaction theories to develop an integrated flight system concept designed to increase the safety, reliability, and performance of single-pilot operations in an increasingly accommodating but stringent national airspace system. This concept, know as the Naturalistic Flight Deck (NFD), uses a form of human-centered automation known as complementary-automation (or complemation) to structure the relationship between the human operator and the aircraft as independent, collaborative agents having complimentary capabilities. The human provides commonsense knowledge, general intelligence, and creative thinking, while the machine contributes specialized intelligence and control, extreme vigilance, resistance to fatigue, and encyclopedic memory. To support the development of the NFD, an initial Concept of Operations has been created and selected normal and non-normal scenarios are presented in this document
- âŠ