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Long-term human hematopoiesis in the SCID-hu mouse.
Coimplantation of small fragments of human fetal thymus and fetal liver into immunodeficient SCID mice resulted in the formation of a unique structure (Thy/Liv). Thereafter, the SCID-hu mice showed reproducible and long-term reconstitution of human hematopoietic activity. For periods lasting 5-11 mo after transplantation, active T lymphopoiesis was observed inside the grafts and cells that were negative for T cell markers were found to have colony-forming units for granulocyte/macrophage (CFU-GM) and erythroid burst-forming unit (BFU-E) activity in the methylcellulose colony assay. In addition, structures similar to normal human bone marrow were observed inside the Thy/Liv grafts, consisting of blast cells, mature and immature forms of myelomonocytic cells, and megakaryocytes. These data indicate long-term maintenance, in vivo, of human progenitor cells for the T lymphoid, myelomonocytic, erythroid, and megakaryocytic lineages. The role of the implanted fetal liver fragments was analyzed using HLA-mismatched Thy/Liv implants. The HLA type of the liver donor was found on T cells and macrophages in the graft. In addition, cells grown in the methylcellulose colony assay and cells in a bone marrow-like structure, the thymic isle, expressed the HLA type of the liver donor. Thus, the Thy/Liv implants provided a microenvironment in which to follow human hematopoietic progenitor cells for multiple lineages. The formation of the Thy/Liv structures also results in a continuous source of human T cells in the peripheral circulation of the SCID-hu mouse. Though present for 5-11 mo, these cells did not engage in a xenograft (graft-versus-host) reaction. This animal model, the first in which multilineage human hematopoietic activity is maintained for long periods of time, should be useful for the analysis of human hematopoiesis in vivo
Quartic double solids with ordinary singularities
We study the mixed Hodge structure on the third homology group of a threefold
which is the double cover of projective three-space ramified over a quartic
surface with a double conic. We deal with the Torelli problem for such
threefolds.Comment: 14 pages, presented at the Conference Arnol'd 7
Homological Type of Geometric Transitions
The present paper gives an account and quantifies the change in topology
induced by small and type II geometric transitions, by introducing the notion
of the \emph{homological type} of a geometric transition. The obtained results
agree with, and go further than, most results and estimates, given to date by
several authors, both in mathematical and physical literature.Comment: 36 pages. Minor changes: A reference and a related comment in Remark
3.2 were added. This is the final version accepted for publication in the
journal Geometriae Dedicat
2-elementary subgroups of the space Cremona group
We give a sharp bound for orders of elementary abelian 2-groups of birational
automorphisms of rationally connected threefolds
Simple Lattice-Models of Ion Conduction: Counter Ion Model vs. Random Energy Model
The role of Coulomb interaction between the mobile particles in ionic
conductors is still under debate. To clarify this aspect we perform Monte Carlo
simulations on two simple lattice models (Counter Ion Model and Random Energy
Model) which contain Coulomb interaction between the positively charged mobile
particles, moving on a static disordered energy landscape. We find that the
nature of static disorder plays an important role if one wishes to explore the
impact of Coulomb interaction on the microscopic dynamics. This Coulomb type
interaction impedes the dynamics in the Random Energy Model, but enhances
dynamics in the Counter Ion Model in the relevant parameter range.Comment: To be published in Phys. Rev.
Neutrino masses, cosmological bound and four zero Yukawa textures
Four zero neutrino Yukawa textures in a specified weak basis, combined with
symmetry and type-I seesaw, yield a highly constrained and predictive
scheme. Two alternately viable light neutrino Majorana mass matrices
result with inverted/normal mass ordering. Neutrino
masses, Majorana in character and predicted within definite ranges with
laboratory and cosmological inputs, will have their sum probed cosmologically.
The rate for decay, though generally below the reach of
planned experiments, could approach it in some parameter region. Departure from
symmetry due to RG evolution from a high scale and consequent CP
violation, with a Jarlskog invariant whose magnitude could almost reach
, are explored.Comment: Published versio
Variational data assimilation for the initial-value dynamo problem
The secular variation of the geomagnetic field as observed at the Earth's surface results from the complex magnetohydrodynamics taking place in the fluid core of the Earth. One way to analyze this system is to use the data in concert with an underlying dynamical model of the system through the technique of variational data assimilation, in much the same way as is employed in meteorology and oceanography. The aim is to discover an optimal initial condition that leads to a trajectory of the system in agreement with observations. Taking the Earth's core to be an electrically conducting fluid sphere in which convection takes place, we develop the continuous adjoint forms of the magnetohydrodynamic equations that govern the dynamical system together with the corresponding numerical algorithms appropriate for a fully spectral method. These adjoint equations enable a computationally fast iterative improvement of the initial condition that determines the system evolution. The initial condition depends on the three dimensional form of quantities such as the magnetic field in the entire sphere. For the magnetic field, conservation of the divergence-free condition for the adjoint magnetic field requires the introduction of an adjoint pressure term satisfying a zero boundary condition. We thus find that solving the forward and adjoint dynamo system requires different numerical algorithms. In this paper, an efficient algorithm for numerically solving this problem is developed and tested for two illustrative problems in a whole sphere: one is a kinematic problem with prescribed velocity field, and the second is associated with the Hall-effect dynamo, exhibiting considerable nonlinearity. The algorithm exhibits reliable numerical accuracy and stability. Using both the analytical and the numerical techniques of this paper, the adjoint dynamo system can be solved directly with the same order of computational complexity as that required to solve the forward problem. These numerical techniques form a foundation for ultimate application to observations of the geomagnetic field over the time scale of centuries
Hopping Transport in the Presence of Site Energy Disorder: Temperature and Concentration Scaling of Conductivity Spectra
Recent measurements on ion conducting glasses have revealed that conductivity
spectra for various temperatures and ionic concentrations can be superimposed
onto a common master curve by an appropriate rescaling of the conductivity and
frequency. In order to understand the origin of the observed scaling behavior,
we investigate by Monte Carlo simulations the diffusion of particles in a
lattice with site energy disorder for a wide range of both temperatures and
concentrations. While the model can account for the changes in ionic activation
energies upon changing the concentration, it in general yields conductivity
spectra that exhibit no scaling behavior. However, for typical concentrations
and sufficiently low temperatures, a fairly good data collapse is obtained
analogous to that found in experiment.Comment: 6 pages, 4 figure
Differential Forms on Log Canonical Spaces
The present paper is concerned with differential forms on log canonical
varieties. It is shown that any p-form defined on the smooth locus of a variety
with canonical or klt singularities extends regularly to any resolution of
singularities. In fact, a much more general theorem for log canonical pairs is
established. The proof relies on vanishing theorems for log canonical varieties
and on methods of the minimal model program. In addition, a theory of
differential forms on dlt pairs is developed. It is shown that many of the
fundamental theorems and techniques known for sheaves of logarithmic
differentials on smooth varieties also hold in the dlt setting.
Immediate applications include the existence of a pull-back map for reflexive
differentials, generalisations of Bogomolov-Sommese type vanishing results, and
a positive answer to the Lipman-Zariski conjecture for klt spaces.Comment: 72 pages, 6 figures. A shortened version of this paper has appeared
in Publications math\'ematiques de l'IH\'ES. The final publication is
available at http://www.springerlink.co
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