The insertion/deletion (I/D) polymorphism in the Angiotensin-converting enzyme gene and cancer risk: a meta-analysis

<p>Abstract</p> <p>Background</p> <p>The insertion/deletion (I/D) polymorphism in the <it>Angiotensin-converting enzyme </it>(<it>ACE</it>) gene has been implicated in susceptibility to cancer, but a large number of studies have reported inconclusive results. The aim of this study is to assess the association between the I/D polymorphism in the <it>ACE </it>gene and cancer risk by meta-analysis.</p> <p>Methods</p> <p>A search was performed in Pubmed database, Embase database, Chinese Biomedical (CBM) database, China National Knowledge Infrastructure (CNKI) database and Weipu database, covering all studies until August 31, 2010. Statistical analysis was performed by using Revman4.2 and STATA 10.0.</p> <p>Results</p> <p>A total of 25 case-control studies comprising 3914 cancer patients and 11391 controls were identified. No significant association was found between the I/D polymorphism and over all cancer risks (OR = 0.88, 95%CI = 0.73-1.06, P = 0.17 for DD+DI vs. II). In the subgroup analysis by ethnicity, no significant association was found among Asians and Europeans for the comparison of DD+DI vs. II. In the subgroup analysis by cancer types, no significant associations were found among lung cancer, breast cancer, prostate cancer, colorectal cancer, gastric cancer for the comparison of DD+DI vs. II. Results from other comparative genetic models also indicated the lack of associations between this polymorphism and cancer risks.</p> <p>Conclusions</p> <p>This meta-analysis suggested that the <it>ACE </it>D/I polymorphism might not contribute to the risk of cancer.</p

HYPERURICEMIA IS NOT ASSOCIATED WITH DECLINE OF KIDNEY FUNCTION IN PRE-DIALYSIS PATIENTS

Clinical epidemiolog

Collaborative effect of fat reduction and ?-tocopherol incorporation on oxidative stability in beef sausages

60th International Meat Industry Conference, MEATCON 2019 -- 22 September 2019 through 25 September 2019 -- -- 153290This study focuses on the changes in oxidative stability and sensory properties of reduced fat and/or ?-tocopherol incorporated sausages during storage at 4°C for 3 months. In order to examine these changes, sausages were formulated with 20% fat and 20% fat+200 ppm ?-tocopherol, coded as C20A0 and C20A1, respectively. Sausages formulated with 10% fat (C10A0) and 10% fat+200 ppm ?-tocopherol (C10A0) were low fat sausages. Reduction of fat by 50% or adding ?-tocopherol initially increased the peroxide values of sausages, but at the end of storage, conversely, reduction of fat and ?-tocopherol addition retarded lipid peroxidation as well as malonaldehyde generation (p0.05). © Published under licence by IOP Publishing Ltd.Firat University Scientific Research Projects Management Unit, FÃœBAP: ID 20131 116-O-506 Türkiye Bilimsel ve Teknolojik Araştirma Kurumu, TÃœBITAKThe authors would like to thank to the Scientific and Technological Research Council of Turkey (TÜBİTAK project number 116-O-506) and Ege University Scientific Research Projects Coordination (EGEBAP project ID 20131) for their financial support

Surgical treatment of Neer type-II fractures of the distal clavicle A meta-analysis

Surger

HYPONATRAEMIA IS A RISK FACTOR FOR INCREASED CARDIOVASCULAR AND NON-CARDIOVASCULAR MORTALITY IN INCIDENT DIALYSIS PATIENTS

Clinical epidemiolog

Schizophrenia and angiotensin converting enzyme gene association in Turkish patients

Background: Although there is an increasing number of publications about the involvement of angiotensin converting enzyme (ACE) insertion/deletion (I/D) polymorphism in mood disorders, none of them has been able to show any linkage between allele or genotypic distributions and schizophrenia. However, there are number of reports associating brain and cerebrospinal fluid ACE levels with schizophrenia. Aim: We investigated the possibility of an association between ACE I/D polymorphism and schizophrenia. Method: Our study comprised 155 unrelated subjects who strictly met DSM-IV criteria for schizophrenia, and 174 healthy unrelated controls, all were of Turkish origin. The analysis of ACE polymorphism was performed using an established polymerase chain reaction method. Results: The I/I genotype of ACE significantly less frequent and I/D genotype was more frequent in schizophrenic patients compared to the controls (p=0.015). This difference was mostly due to the significant difference in men but not in women. The ACE genotypes did not differ between clinical subgroups of schizophrenia (p=0.10). Conclusion: The results of our study suggests that ACE I/I polymorphism is associated with schizophrenia at least in this group of Turkish patients. © Universitätsverlag Ulm GmbH 2004