ANALISA AUTOMATIC GUIDED VEHICLE (AGV) PENGANGKUT MESIN KAPASITAS 500 KG

Automatic Guided Vehicle (AGV) adalah sebuah mobile robot yang mengikuti petunjuk atau garis yang diberikan di lantai atau menggunakan laser atau dapat pula berupa logam bermedan megnet untuk bergerak kearah tertentu. Penelitian ini akan dianalisa cara untuk Mengefektifkan proses pemindahan secara manual menjadi otomatis sehingga dapat menghilangkan 1 MP dan menekan biaya produksi. Dari hasil penelitian diperoleh hasil daya output 0,2 kW pada torsi 0,6292 Nm dengan tingkat efesiensi mencapai 75%. Untuk hasil perhitungan hubungan antara daya, kecepatan dan torsi serta pengujian maka diperoleh beban maksimal yang dapat diangkut oleh robot adalah 500 kg / 5000 N, jika di asumsikan tanpa beban adalah 30 kg / 300 N (berat rangakaian) sinyal pwm dengan jumlah pulsa 240 atau dengan kecepatan motor 3000 RPM

Determinants for hospitalization in " low-risk" community acquired pneumonia

BACKGROUND: A variable decision in managing community acquired pneumonia (CAP) is the initial site of care; in-patient versus outpatient. These variations persist despite comprehensive practice guidelines. Patients with a Pneumonia Severity Index (PSI) score lower than seventy have low risk for complications and outpatient antibiotic management is recommended in this group. These patients are generally below the age of fifty years, non-nursing home residents, HIV negative and have no major cardiac, hepatic, renal or malignant diseases. METHODS: A retrospective analysis of 296 low-risk CAP patients evaluated within a year one period at St. Agnes Hospital, Baltimore, Maryland was undertaken. All patients were assigned a PSI score. 208 (70%) were evaluated and discharged from the emergency department (E.D.) to complete outpatient antibiotic therapy, while 88 (30%) were hospitalized. Patients were sub-stratified into classes I-V according to PSI. A comparison of demographic, clinical, social and financial parameters was made between the E.D. discharged and hospitalized groups. RESULTS: Statistically significant differences in favor of the hospitalized group were noted for female gender (CI: 1.46-5.89, p= 0.0018), African Americans (CI: 0.31-0.73, p= 0.004), insurance coverage (CI: 0.19-0.63, p= 0.0034), temperature (CI: 0.04-0.09, p= 0.0001) and pulse rate (CI: 0.03-0.14, p= 0.0001). No statistically significant differences were observed between the two groups for altered mental status, hypotension, tachypnea, laboratory/radiological parameters and social indicators (p>0.05). The average length of stay for in-patients was 3.5 days at about eight time's higher cost than outpatient management. There was no difference in mortality or treatment failures between the two groups. The documentation rate and justifications for hospitalizing low risk CAP patients by admitting physicians was less than optimal. CONCLUSIONS: High fever, tachycardia, female gender, African- American race and medical insurance coverage are determinants for hospitalization among low risk CAP patients in our study. The average length of stay for in-patients was 3.5 days (3 to 5 days). The cost of in-patient care was about eight times higher than outpatient management. This study supports the recommendation of using the PSI for E.D evaluation of patients in appropriate social settings

Factors influencing the utilization of public primary health care facilities in Kumbotso Local Government Area of Kano State, Nigeria

This study is concerned with the examination of factors responsible for the utilization of public primary healthcare services in Kumbotso Local Government Area of Kano State. Primary health care (PHC) can be considered the first level of contact between the patient and the health care system. The Andersen Model of Healthcare Utilisation was used as theoretical guide and frame of analysis in the study. The model is a conceptual framework developed and used to understand health behaviour and possible reasons for utilization of available healthcare facilities and services. The study is a survey research design. A total of 295 respondents were sampled for the study. These include 285 members of the public who were sampled through a multi stage cluster sampling for questionnaire administration and 10 other respondents (Doctors, Nurses, and Community Health Extension Workers) who were purposively sampled for in-depth interview. The study utilized both qualitative and quantitative instruments for data collection. The findings revealed that awareness has influence on the utilization of PHC services in the study area. It also revealed that even though there is high rate of patronage of PHC facilities in the area, respondents reported facing problems associated with availability of drugs, healthcare personnel for effective PHC delivery. It recommended that the government should ensure compliance with the WHO benchmark for PHC delivery.Keywords: Primary health care, Awareness, Availability, Access, Health workers behaviou

Correlates of postpartum sexual activity and contraceptive use in Kano, northern Nigeria

Practices related to resumption of coitus after childbirth remains poorly documented in Nigeria. This study examined factors associated with sexual intercourse, delivery-coitus interval, and contraceptive use among postpartum women attending a tertiary centre in Kano, northern Nigeria. A cross section of 317 women attending immunization, postnatal and family planning clinics within 12 months of childbirth was interviewed using a structured questionnaire. Vaginal intercourse was resumed by most women (n=212; 66.9%, 95% Confidence Interval (CI) = 61.8%, 72.2%) with delivery-coitus resumption interval (mean ± SD) of 9.6±5.2 weeks postpartum. The majority (67.9%) resumed sexual activity within 8 weeks of delivery. Nearly two-thirds 65.6% (n=139/212) of the sexually active women reported current use of contraceptives. Onset of postpartum sexual activity was independently associated with mode of delivery adjusted odds ratio (AOR) (95%CI)= 1.10 (1.03,1.78), baby‘s age AOR (95%CI) =2.10 (1.27, 8.70), number of living children AOR (95%CI)=1.21 (1.07,1.79), onset of menstruation AOR (95%CI)=0.34 (0.17,0.69) and co-habitation AOR (95%CI)=0.47 (0.016, 0.14). Contraceptive use was predicted by educational status, sexual activity, baby‘s age and menstruation. Most women attending maternal and child health clinics resumed sexual intercourse within 2 months of delivery, but only two-thirds used modern contraceptive methods. Contraceptive counseling should commence early, preferably during pregnancy.Keywords: sexual intercourse, postpartum, contraceptive use, predictors, Nigeri

Hepatitis C Virus Infection in Blood Donors: An Emerging Risk to Transfusion Services

Background: Hepatitis C infection is transmissible via transfusion of blood and blood products. Little work exists in local literature on its prevalence. Methods: A prospective study aimed at documenting the sero -prevalence of hepatitis C virus infection in blood donors in a tropical environment. Results: A total of four thousand six hundred and thirty three regular blood donors were screened over a 3 year period. Age of donors ranged between 19 and 42 years with a mean of 33 years. Two hundred and forty one donors (5.2%) were seropositive. Age- specific prevalence rates ranged from 0.09% to 1.7%.Yearly prevalence rates ranged from 3.4% to 6.9%. Conclusions: This study shows that the prevalence of HCV infections in our blood donors is high and requires active and sensitive screening in order to improve the safety of banked blood.Introduction: Sanguine et produits du sang, il y a un tr\ue8s peu du documents dans la litt\ue9rature locale sur sa fr\ue9quence. M\ue9thodes: Une \ue9tude prospective qui vise \ue0 documenter la s\ue9ro-fr\ue9quence d'infection du Virus C h\ue9patite dans le sang des donneurs dans un milieu tropique. R\ue9sultats: Un nombre total de quatre mille six cents trente trois donneurs r\ue9guliers ont fait le test de d\ue9pistage au cours d'une p\ue9riode de 3 ans. Les donneurs avaient la tranche d'\ue2ge d'entre 19 et 42 ans avec un moyen de 33 ans. Deux cents et quarante et un donneurs (5,2%) \ue9taient s\ue9ropositifs. La tranche du taux d'\ue2ge sp\ue9cifique de la fr\ue9quence entre 0,09% et 1,7%. Taux annuel de la fr\ue9quence entre 3,4% et 6,9%. Conclusion: Cette \ue9tude montre que la fr\ue9quence des infections du VCH dans le sang de nos donneurs est \ue9lev\ue9e et demande un d\ue9pistage actif et sensitif afin d'am\ue9liorer le sans danger des sangs dans la banque du sang

The effect of acute respiratory events and respiratory stimulants on EEG-recorded brain activity in neonates: a systematic review

Objective: We conducted a systematic review to investigate electroencephalography (EEG) changes during periods of acute respiratory events such as apnoea and the effect of respiratory stimulants on EEG features in infants. Methods: Studies examining respiration and EEG-recorded brain activity in human neonates between 28 and 42 weeks postmenstrual age were included. Two reviewers independently screened all records and included studies were assessed using the Joanna Briggs Institute Critical Appraisal Tool. The protocol was registered in PROSPERO (CRD42022339873). Results: We identified 14 studies with a total of 534 infants. Nine articles assessed EEG changes in relation to apnoea, one assessed hiccups, and four investigated the effect of respiratory stimulants. The relationship between neonatal apnoea and EEG changes was inconsistent; EEG suppression and decreased amplitude and frequency were observed during some, but not all, apnoeas. Respiratory stimulants increased EEG continuity compared with before use. Conclusions: Current studies in this area are constrained by small sample sizes. Diverse exposure definitions and outcome measures impact inference. Significance: This review highlights the need for further work; understanding the relationship between respiration and the developing brain is key to mitigating the long-term effects of apnoea

Correlates of serum lipoprotein (A) in children and adolescents in the United States. The third National Health Nutrition and Examination Survey (NHANES-III)

OBJECTIVE: To determine the correlates of serum lipoprotein (a) (Lp(a)) in children and adolescents in the United States. METHODS: Cross-sectional study using representative data from a US national sample for persons aged 4–19 years participating in The Third National Health Nutrition and Examination Survey (NHANES-III). RESULTS: We observed ethnicity-related differences in levels of Lp(a) > 30 mg/dl, with values being markedly higher in African American (black) than nonhispanic white (white) and Mexican American children in multivariate model (P < 0.001). Higher levels of Lp(a) > 30 mg/dl associated with parental history of body mass index and residence in metro compared to nonmetro in Blacks, and high birth weight in Mexican American children in the NHANES-III. In the entire group, total cholesterol (which included Lp(a)) and parental history of premature heart attack/angina before age 50 (P < 0.02) showed consistent, independent, positive association with Lp(a). In subgroup analysis, this association was only evident in white (P = 0.04) and black (P = 0.05) children. However, no such collective consistent associations of Lp(a) were found with age, gender, or birth weight. CONCLUSION: Ethnicity-related differences in mean Lp(a) exist among children and adolescents in the United States and parental history of premature heart attack/angina significantly associated with levels of Lp(a) in children. Further research on the associations of Lp(a) levels in childhood with subsequent risk of atherosclerosis is needed

Nuclear receptor coactivator/coregulator NCoA6(NRC) is a pleiotropic coregulator involved in transcription, cell survival, growth and development

NCoA6 (also referred to as NRC, ASC-2, TRBP, PRIP and RAP250) was originally isolated as a ligand-dependent nuclear receptor interacting protein. However, NCoA6 is a multifunctional coregulator or coactivator necessary for transcriptional activation of a wide spectrum of target genes. The NCoA6 gene is amplified and overexpressed in breast, colon and lung cancers. NCoA6 is a 250 kDa protein which harbors a potent N-terminal activation domain, AD1; and a second, centrally-located activation domain, AD2, which is necessary for nuclear receptor signaling. The intrinsic activation potential of NCoA6 is regulated by its C-terminal STL regulatory domain. Near AD2 is an LxxLL-1 motif which interacts with a wide spectrum of ligand-bound NRs with high-affinity. A second LxxLL motif (LxxLL-2) located towards the C-terminal region is more restricted in its NR specificity. The potential role of NCoA6 as a co-integrator is suggested by its ability to enhance transcriptional activation of a wide variety of transcription factors and from its in vivo association with a number of known cofactors including CBP/p300. NCoA6 has been shown to associate with at least three distinct coactivator complexes containing Set methyltransferases as core polypeptides. The composition of these complexes suggests that NCoA6 may play a fundamental role in transcriptional activation by modulating chromatin structure through histone methylation. Knockout studies in mice suggest that NCoA6 is an essential coactivator. NCoA6-/- embryos die between 8.5-12.5 dpc from general growth retardation coupled with developmental defects in the heart, liver, brain and placenta. NCoA6-/- MEFs grow at a reduced rate compared to WT MEFs and spontaneously undergo apoptosis, indicating the importance of NCoA6 as a prosurvival and anti-apoptotic gene. Studies with NCoA6+/- and conditional knockout mice suggest that NCoA6 is a pleiotropic coregulator involved in growth, development, wound healing and maintenance of energy homeostasis