Oxygen-induced p(2x3) reconstruction on Mo(112) studied by LEED and STM

The open trough-and-row Mo(112) surface serves as substrate for the epitaxial growth of MoO2. In the early stage of oxygen exposure, oxygen chemisorption induces a p(2x3) surface reconstruction of the missing row type on Mo(112). The surface structure of this reconstructed surface has been studied in detail by low-energy electron diffraction and scanning tunneling microscope. The experimental findings can be explained based on the effective medium theory for oxygen adsorption on transition-metal surfaces, providing a structure model for the oxygen-modified Mo(112) surface. The structure model allows the discussion of the oxygen-chemisorbed surface phase as a possible precursor state fo

Lineage-Specific Chimerism and Outcome After Hematopoietic Stem Cell Transplantation for DOCK8 Deficiency

Bi-allelic variants in the dedicator of cytokinesis 8 (DOCK8) gene cause a combined immunodeficiency, characterized by recurrent sinopulmonary and skin infections, food allergies, eczema, eosinophilia, and elevated IgE. Long-term outcome is poor given susceptibility to infections, malignancy, and vascular complications. Allogeneic hematopoietic stem cell transplantation is currently the only curative treatment option and has shown promising outcome. The impact of mixed chimerism on long-term outcome is unclear. We reasoned that reversal of disease phenotype would depend on cell lineage-specific chimerism. DOCK8 variants were confirmed by Sanger and/or exome sequencing and immunoblot and/or intracellular flow cytometry. Donor chimerism was analyzed by XY-fluorescence in situ hybridization or quantitative short tandem repeat PCR. Outcome was assessed by laboratory tests, lymphocyte subsets, intracellular DOCK8 protein flow cytometry, T-cell proliferation analysis, and multiparameter immunoblot allergy screening. We report on nine patients, four of whom with mixed chimerism, with a median follow-up of 78~months after transplantation. Overall, we report successful transplantation with improvement of susceptibility to infections and allergies, and resolution of eczema in all patients. Immunological outcome in patients with mixed chimerism suggests a selective advantage for wild-type donor T-cells but lower donor B-cell chimerism possibly results in a tendency to hypogammaglobulinemia. No increased infectious and allergic complications were associated with mixed chimerism. Aware of the relatively small cohort size, we could not demonstrate a consistent detrimental effect of mixed chimerism on clinical outcomes. We nevertheless advocate aiming for complete donor chimerism in treating DOCK8 deficiency, but recommend reduced toxicity conditioning

Bounds on neutrino masses from leptogenesis in type-II see-saw models

The presence of the triplet $\Delta_{L}$ in left-right symmetric theories leads to type-II see-saw mechanism for the neutrino masses. In these models, assuming a normal mass hierarchy for the heavy Majorana neutrinos, we derive a lower bound on the mass of the lightest of heavy Majorana neutrino from the leptogenesis constraint. From this bound we establish a consistent picture for the hierarchy of heavy Majorana neutrinos in a class of left right symmetric models in which we identify the neutrino Dirac mass matrix with that of Fritzsch type charged lepton mass matrix. It is shown that these values are compatible with the current neutrino oscillation data.Comment: minor typos corrected, references added, match with published versio

Do experiments suggest a hierarchy problem?

The hierarchy problem of the scalar sector of the standard model is reformulated, emphasizing the role of experimental facts that may suggest the existence of a new physics large mass scale, for instance indications of the instability of the matter, or indications in favor of massive neutrinos. In the see-saw model for the neutrino masses a hierarchy problem arises if the mass of the right-handed neutrinos is larger than approximatively $10^7$ GeV: this problem, and its possible solutions, are discussed.Comment: revtex, 4 pages, 1 figur

Probing top charged-Higgs production using top polarization at the Large Hadron Collider

We study single top production in association with a charged Higgs in the type II two Higgs doublet model at the Large Hadron Collider. The polarization of the top, reflected in the angular distributions of its decay products, can be a sensitive probe of new physics in its production. We present theoretically expected polarizations of the top for top charged-Higgs production, which is significantly different from that in the closely related process of t-W production in the Standard Model. We then show that an azimuthal symmetry, constructed from the decay lepton angular distribution in the laboratory frame, is a sensitive probe of top polarization and can be used to constrain parameters involved in top charged-Higgs production.Comment: 22 pages, 18 Figures, Discussions about backgrounds and NLO corrections added, figures modified, references added, Version published in JHE

On the nature of the fourth generation neutrino and its implications

We consider the neutrino sector of a Standard Model with four generations. While the three light neutrinos can obtain their masses from a variety of mechanisms with or without new neutral fermions, fourth-generation neutrinos need at least one new relatively light right-handed neutrino. If lepton number is not conserved this neutrino must have a Majorana mass term whose size depends on the underlying mechanism for lepton number violation. Majorana masses for the fourth generation neutrinos induce relative large two-loop contributions to the light neutrino masses which could be even larger than the cosmological bounds. This sets strong limits on the mass parameters and mixings of the fourth generation neutrinos.Comment: To be published. Few typos corrected, references update

Low energy consequences from supersymmetric models with left-right symmetry

We consider several low energy consequences arising from a class of supersymmetric models based on the gauge groups $SU(2)_L\times SU(2)_R \times U(1)_{B-L}$ and $SU(4)_C\times SU(2)_L \times SU(2)_R$ in which the gauge hierarchy and $\mu$ problems have been resolved. There are important constraints on the MSSM parameters $\tan \beta (\simeq m_t/m_b)$, $B$ and $\mu$, and we discuss how they are reconciled with radiative electroweak breaking. We also consider the ensuing sparticle and Higgs spectroscopy, as well as the decays $b\to s \gamma$ and $\mu \to e \gamma$. The latter process may be amenable to experimental tests through an order of magnitude increase in sensitivity.Comment: 17 pages, latex2

Mass predictions based on a supersymmetric SU(5) fixed point

I examine the possibility that the third generation fermion masses are determined by an exact fixed point of the minimal supersymmetric SU(5) model. When one-loop supersymmetric thresholds are included, this unified fixed point successfully predicts the top quark mass, 175 +(-) 2 GeV, as well as the weak mixing angle. The bottom quark mass prediction is sensitive to the supersymmetric thresholds; it approaches the measured value for mu <0 and very large unified gaugino mass. The experimental measurement of the tau lepton mass determines tan(beta), and the strong gauge coupling and fine structure constant fix the unification scale and the unified gauge coupling.Comment: 40 pages, 9 figures, 9 tables, Revtex

Examining leptogenesis with lepton flavor violation and the dark matter abundance

Within a supersymmetric (SUSY) type-I seesaw framework with flavor-blind universal boundary conditions, we study the consequences of requiring that the observed baryon asymmetry of the Universe be explained by either thermal or non-thermal leptogenesis. In the former case, we find that the parameter space is very constrained. In the bulk and stop-coannihilation regions of mSUGRA parameter space (that are consistent with the measured dark matter abundance), lepton flavor-violating (LFV) processes are accessible at MEG and future experiments. However, the very high reheat temperature of the Universe needed after inflation (of about 10^{12} GeV) leads to a severe gravitino problem, which disfavors either thermal leptogenesis or neutralino dark matter. Non-thermal leptogenesis in the preheating phase from SUSY flat directions relaxes the gravitino problem by lowering the required reheat temperature. The baryon asymmetry can then be explained while preserving neutralino dark matter, and for the bulk or stop-coannihilation regions LFV processes should be observed in current or future experiments.Comment: 20 pages, 5 figures, 1 tabl

Effective Lagrangian approach to neutrinoless double beta decay and neutrino masses

Neutrinoless double beta ($0\nu\beta\beta$) decay can in general produce electrons of either chirality, in contrast with the minimal Standard Model (SM) extension with only the addition of the Weinberg operator, which predicts two left-handed electrons in the final state. We classify the lepton number violating (LNV) effective operators with two leptons of either chirality but no quarks, ordered according to the magnitude of their contribution to \znbb decay. We point out that, for each of the three chirality assignments, $e_Le_L, e_Le_R$ and $e_Re_R$, there is only one LNV operator of the corresponding type to lowest order, and these have dimensions 5, 7 and 9, respectively. Neutrino masses are always induced by these extra operators but can be delayed to one or two loops, depending on the number of RH leptons entering in the operator. Then, the comparison of the $0\nu\beta\beta$ decay rate and neutrino masses should indicate the effective scenario at work, which confronted with the LHC searches should also eventually decide on the specific model elected by nature. We also list the SM additions generating these operators upon integration of the heavy modes, and discuss simple realistic examples of renormalizable theories for each case.Comment: Accepted for publication. Few misprints corrected and new references adde