Emission-Line Properties of z > 4 Quasars

We present results of a program of high signal-to-noise spectroscopy for 44 QSOs at redshifts > 4 using the MMT and Keck observatories. The quasar spectra cover 1100 -- 1700 A in the rest frame for sources spanning a luminosity range of approximately 2 orders of magnitude. Comparisons between these data and spectra of lower redshift quasars reveal a high degree of similarity, although differences are present in the profiles and the strengths of some emission features. An examination of the luminosity dependence of the emission lines reveals evidence for a weak or absent Baldwin effect among z > 4 QSOs. We compare measurements for objects in our sample with results from other high redshift surveys characterized by different selection techniques. Distributions of equivalent widths for these different ensembles are consistent with a common parent population, suggesting that our sample is not strongly biased, or in any case, subject to selection effects that are not significantly different from other surveys, including the Sloan Digital Sky Survey. Based on this comparison, we tentatively conclude that the trends identified here are representative of high z QSOs. In particular, the data bolster indications of supersolar metallicities in these luminous, high-z sources, which support scenarios that assume substantial star formation at epochs preceding or concurrent with the QSO phenomena.Comment: 26 pages (incl. 9 figures), AASTeX v5.0, to appear in The Astrophysical Journa

Quasar outflow energetics from broad absorption line variability

Quasar outflows have long been recognized as potential contributors to the co-evolution between supermassive black holes (SMBHs) and their host galaxies. The role of outflows in AGN feedback processes can be better understood by placing observational constraints on wind locations and kinetic energies. We utilize broad absorption line (BAL) variability to investigate the properties of a sample of 71 BAL quasars with P$\thinspace$V broad absorption. The presence of P$\thinspace$V BALs indicates that other BALs like C$\thinspace$IV are saturated, such that variability in those lines favours clouds crossing the line of sight. We use these constraints with measurements of BAL variability to estimate outflow locations and energetics. Our data set consists of multiple-epoch spectra from the Sloan Digital Sky Survey and MDM Observatory. We detect significant (4$\sigma$) BAL variations from 10 quasars in our sample over rest frame time-scales between < 0.2-3.8 yr. Our derived distances for the 10 variable outflows are nominally < 1-10 pc from the SMBH using the transverse-motion scenario, and < 100-1000 pc from the central source using ionization-change considerations. These distances, in combination with the estimated high outflow column densities (i.e. $N_{\textrm{H}}$ > 10$^{22}$ cm$^{-2}$), yield outflow kinetic luminosities between ~ 0.001-1 times the bolometric luminosity of the quasar, indicating that many absorber energies within our sample are viable for AGN feedback.Comment: 19 pages, 3 figures, 4 tables, 1 supplementary figure, accepted to MNRA

Ultraviolet spectroscopy of old novae and symbiotic stars

The IUE spectra are presented for two old novae and for two of the symbiotic variables. Prominent emission line spectra are revealed as a continuum whose appearance is effected by the system inclination. These data provide evidence for hot companions in the symbiotic stars, making plausible the binary model for these peculiar stars. Recent IUE spectra of dwarf novae provide additional support for the existence of optically thick accretion disks in active binary systems. The ultraviolet data of the eclipsing dwarf novae EX Hya and BV Cen appear flatter than for the noneclipsing systems, an effect which could be ascribed to the system inclination

Ultraviolet and optical properties of Narrow-Line Seyfert 1 galaxies

Narrow Line Seyfert 1 (NLS1) galaxies are remarkable for their extreme continuum and emission line properties which are not well understood. New results bearing on the spectroscopic characteristics of these objects are presented here, with the aim of establishing their typical ultraviolet and optical spectral behavior. We employ HST observations of 22 NLS1s, which represent a substantial improvement over previous work in terms of data quality and sample size. High signal-to-noise NLS1 composite spectra are constructed, allowing accurate measurements of the continuum shape and the strengths, ratios, and widths for lines, including weak features which are barely identifiable in other Active Galactic Nuclei (AGN) composites. We find that the NLS1 sources have redder UV-blue continua than those typically measured in other quasars and Seyferts. Objects with UV line absorption show redder spectra, suggesting that dust is important in modifying the continuum shapes. The data also permit a detailed investigation of the previously proposed link between NLS1s and z >~ 4 quasars. Direct comparison of their composite spectra, as well as a Principal Component Analysis, suggest that high-z QSOs do not show a strong preference toward NLS1 behavior.Comment: 23 pages (incl. 9 figures, 4 tables), to appear in The Publications of the Astronomical Society of the Pacifi

Threshold criteria for incipient sediment motion on an inclined bedform in the presence of oscillating-grid turbulence

Here, we report laboratory experiments to investigate the threshold criteria for incipient sediment motion in the presence of oscillating-grid turbulence, with the bed slope inclined at angles between the horizontal and the repose limit for the sediment. A set of nine mono-disperse sediment types was used with size ranges normally associated with either the hydraulically-smooth or transitional regimes. Measurements of the (turbulent) fluid velocity field, in the region between the grid and bedform's surface, were obtained using two-dimensional particle imaging velocimetry. Statistical analysis of the velocity data showed that the turbulence had a anisotropic structure, due to the net transfer of energy from the normal to the tangential velocity components in the near-bed region, and that the fluctuations were dominant compared to the secondary mean flow. The sediment threshold criteria for horizontal bedforms were compared with, and found to be in good qualitative agreement with the standard Shields curve. For non-horizontal bedforms, the bed mobility was found to increase with increasing bed slope, and the threshold criteria were compared with previously-reported theoretical models, based on simple force-balance arguments

Long-lived charged multiple-exciton complexes in strong magnetic fields

We consider the charged exciton complexes of an ideal two-dimensional electron-hole system in the limit of strong magnetic fields. A series of charged multiple-exciton states is identified and variational and finite-size exact diagonalization calculations are used to estimate their binding energies. We find that, because of a hidden symmetry, bound states of excitons and an additional electron cannot be created by direct optical absorption and, once created, have an infinite optical recombination lifetime. We also estimate the optical recombination rates when electron and hole layers are displaced and the hidden symmetry is violated.Comment: 12 pages + 2 PostScript figures, Revtex, Submitted to Phys. Rev. Let

EVA Glove Research Team

The goal of the basic research portion of the extravehicular activity (EVA) glove research program is to gain a greater understanding of the kinematics of the hand, the characteristics of the pressurized EVA glove, and the interaction of the two. Examination of the literature showed that there existed no acceptable, non-invasive method of obtaining accurate biomechanical data on the hand. For this reason a project was initiated to develop magnetic resonance imaging as a tool for biomechanical data acquisition and visualization. Literature reviews also revealed a lack of practical modeling methods for fabric structures, so a basic science research program was also initiated in this area

Dynamin-related protein 1 is required for normal mitochondrial bioenergetic and synaptic function in CA1 hippocampal neurons.

Disrupting particular mitochondrial fission and fusion proteins leads to the death of specific neuronal populations; however, the normal functions of mitochondrial fission in neurons are poorly understood, especially in vivo, which limits the understanding of mitochondrial changes in disease. Altered activity of the central mitochondrial fission protein dynamin-related protein 1 (Drp1) may contribute to the pathophysiology of several neurologic diseases. To study Drp1 in a neuronal population affected by Alzheimer's disease (AD), stroke, and seizure disorders, we postnatally deleted Drp1 from CA1 and other forebrain neurons in mice (CamKII-Cre, Drp1lox/lox (Drp1cKO)). Although most CA1 neurons survived for more than 1 year, their synaptic transmission was impaired, and Drp1cKO mice had impaired memory. In Drp1cKO cell bodies, we observed marked mitochondrial swelling but no change in the number of mitochondria in individual synaptic terminals. Using ATP FRET sensors, we found that cultured neurons lacking Drp1 (Drp1KO) could not maintain normal levels of mitochondrial-derived ATP when energy consumption was increased by neural activity. These deficits occurred specifically at the nerve terminal, but not the cell body, and were sufficient to impair synaptic vesicle cycling. Although Drp1KO increased the distance between axonal mitochondria, mitochondrial-derived ATP still decreased similarly in Drp1KO boutons with and without mitochondria. This indicates that mitochondrial-derived ATP is rapidly dispersed in Drp1KO axons, and that the deficits in axonal bioenergetics and function are not caused by regional energy gradients. Instead, loss of Drp1 compromises the intrinsic bioenergetic function of axonal mitochondria, thus revealing a mechanism by which disrupting mitochondrial dynamics can cause dysfunction of axons

MicroRNA-125b transforms myeloid cell lines by repressing multiple mRNA

Background: We previously described a t(2;11)(p21;q23) chromosomal translocation found in patients with myelodysplasia or acute myeloid leukemia that leads to over-expression of the microRNA miR-125b, and we showed that transplantation of mice with murine stem/progenitor cells overexpressing miR-125b is able to induce leukemia. In this study, we investigated the mechanism of myeloid transformation by miR-125b. Design and Methods: To investigate the consequences of miR-125b over-expression on myeloid differentiation, apoptosis and proliferation, we used the NB4 and HL60 human promyelocytic cell lines and the 32Dclone3 murine promyelocytic cell line. To test whether miR-125b is able to transform myeloid cells, we used the non-tumorigenic and interleukin-3-dependent 32Dclone3 cell line over-expressing miR-125b, in xenograft experiments in nude mice and in conditions of interleukin-3 deprivation. To identify new miR-125b targets, we compared, by RNA-sequencing, the transcriptome of cell lines that do or do not over-express miR-125b. Results: We showed that miR-125b over-expression blocks apoptosis and myeloid differentiation and enhances proliferation in both species. More importantly, we demonstrated that miR-125b is able to transform the 32Dclone3 cell line by conferring growth independence from interleukin-3; xenograft experiments showed that these cells form tumors in nude mice. Using RNA-sequencing and quantitative real-time polymerase chain reaction experiments, we identified multiple miR-125b targets. We demonstrated that ABTB1, an anti-proliferative factor, is a new direct target of miR-125b and we confirmed that CBFB, a transcription factor involved in hematopoiesis, is also targeted by miR-125b. MiR-125b controls apoptosis by down-regulating genes involved in the p53 pathway including BAK1 and TP53INP1. Conclusions: This study demonstrates that in a myeloid context, miR-125b is an oncomiR able to transform cell lines. miR-125b blocks myeloid differentiation in part by targeting CBFB, blocks apoptosis through down-regulation of multiple genes involved in the p53 pathway, and confers a proliferative advantage to human and mouse myeloid cell lines in part by targeting ABTB1.Leukemia & Lymphoma Society of AmericaNational Institutes of Health (U.S.) (NIH grant DK068348)National Institutes of Health (U.S.) (NIH grant 5P01 HL066105