8,098 research outputs found
An analysis of the general content, grade placement, and philosophy of state courses of study in arithmetic for grades one to six.
Thesis (Ed.M.)--Boston Universit
Explanation and Elaboration Document for the STROBE-Vet Statement: Strengthening the Reporting of Observational Studies in EpidemiologyâVeterinary Extension
The STROBE (Strengthening the Reporting of Observational Studies in Epidemiology) statement was first published in 2007 and again in 2014. The purpose of the original STROBE was to provide guidance for authors, reviewers and editors to improve the comprehensiveness of reporting; however, STROBE has a unique focus on observational studies. Although much of the guidance provided by the original STROBE document is directly applicable, it was deemed useful to map those statements to veterinary concepts, provide veterinary examples and highlight unique aspects of reporting in veterinary observational studies. Here, we present the examples and explanations for the checklist items included in the STROBE-Vet Statement. Thus, this is a companion document to the STROBE-Vet Statement Methods and process document, which describes the checklist and how it was developed
Dimensional Crossover in the Large N Limit
We consider dimensional crossover for an Landau-Ginzburg-Wilson model
on a -dimensional film geometry of thickness in the large -limit. We
calculate the full universal crossover scaling forms for the free energy and
the equation of state. We compare the results obtained using ``environmentally
friendly'' renormalization with those found using a direct, non-renormalization
group approach. A set of effective critical exponents are calculated and
scaling laws for these exponents are shown to hold exactly, thereby yielding
non-trivial relations between the various thermodynamic scaling functions.Comment: 25 pages of PlainTe
Comparison of Subjective Responses to Oral and Intravenous Alcohol Administration under Similar Systemic Exposures
Objective
To test whether an individual's subjective responses to alcohol are similar when the breath alcohol concentration (BrAC) trajectory resulting from oral administration is matched by intravenous administration.
Background
Individuals perceive the effects of alcohol differently, and the variation is commonly used in research assessing the risk for developing an alcohol use disorder. Such research is supported by both oral and intravenous alcohol administration techniques, and any differences attributable to the route employed should be understood.
Methods
We conducted a 2âsession, withinâsubject study in 44 young adult, healthy, nonâdependent drinkers (22 females and 22 males). In the first session, subjects ingested a dose of alcohol which was individually calculated, on the basis of total body water, to yield a peak BrAC near 80 mg/dl, and the resulting BrAC trajectory was recorded. A few days later, subjects received an intravenous alcohol infusion rate profile, preâcomputed to replicate each individual's oral alcohol BrAC trajectory. In both sessions, we assessed 4 subjective responses to alcohol: SEDATION, SIMULATION, INTOXICATION, and HIGH; at baseline and frequently for 4 hours. We compared the individualsâ baselineâcorrected responses at peak BrAC and at halfâpeak BrAC on both the ascending and descending limbs. We also computed and compared Pearsonâproduct moment correlations of responses by route of administration, the Mellanby measure of acute adaptation to alcohol, and the area under the entire response curve for each subjective response.
Results
No significant differences in any measure could be attributed to the route of alcohol administration. Eleven of 12 response comparisons were significantly correlated across the routes of alcohol administration, with 9 surviving correction for multiple measures, as did the Mellanby effect and area under the response curve correlations.
Conclusion
The route of alcohol administration has a minimal effect on subjective responses to alcohol when an individual's BrAC exposure profiles are similar
Modular Invariance of Finite Size Corrections and a Vortex Critical Phase
We analyze a continuous spin Gaussian model on a toroidal triangular lattice
with periods and where the spins carry a representation of the
fundamental group of the torus labeled by phases and . We find the
{\it exact finite size and lattice corrections}, to the partition function ,
for arbitrary mass and phases . Summing over phases gives
the corresponding result for the Ising model. The limits and
do not commute. With the model exhibits a {\it vortex
critical phase} when at least one of the is non-zero. In the continuum or
scaling limit, for arbitrary , the finite size corrections to are
{\it modular invariant} and for the critical phase are given by elliptic theta
functions. In the cylinder limit the ``cylinder charge''
is a non-monotonic function of that ranges from
for to zero for .Comment: 12 pages of Plain TeX with two postscript figure insertions called
torusfg1.ps and torusfg2.ps which can be obtained upon request from
[email protected]
Assessing the effects of the first 2 years of industry-led badger culling in England on the incidence of bovine tuberculosis in cattle in 2013â2015
Culling badgers to control the transmission of bovine tuberculosis (TB) between this wildlife reservoir and cattle has been widely debated. Industry-led culling began in Somerset and Gloucestershire between August and November 2013 to reduce local badger populations. Industry-led culling is not designed to be a randomised and controlled trial of the impact of culling on cattle incidence. Nevertheless, it is important to monitor the effects of the culling and, taking the study limitations into account, perform a cautious evaluation of the impacts. A standardised method for selecting areas matched to culling areas in factors found to affect cattle TB risk has been developed to evaluate the impact of badger culling on cattle TB incidence. The association between cattle TB incidence and badger culling in the first two years has been assessed. Descriptive analyses without controlling for confounding showed no association between culling and TB incidence for Somerset, or for either of the buffer areas for the first two years since culling began. A weak association was observed in Gloucestershire for Year 1 only. Multivariable analysis adjusting for confounding factors showed that reductions in TB incidence were associated with culling in the first two years in both the Somerset and Gloucestershire intervention areas when compared to areas with no culling (IRR: 0.79, 95%CI: 0.72-0.87, p<0.001 and IRR: 0.42, 95%CI: 0.34-0.51, p<0.001 respectively). An increase in incidence was associated with culling in the 2 km buffer surrounding the Somerset intervention area (IRR: 1.38, 95%CI: 1.09-1.75, p=0.008), but not in Gloucestershire (IRR: 0.91, 95%CI: 0.77-1.07, p=0.243). As only two intervention areas with two yearsâ of data are available for analysis, and the biological cause-effect relationship behind the statistical associations is difficult to determine, it would be unwise to use these findings to develop generalisable inferences about the effectiveness of the policy at present
Prevalence of familial cluster headache: a systematic review and meta-analysis
INTRODUCTION: The population rate of familial cluster headache (CH) has been reported to be as high as 20% however this varies considerably across studies. To obtain a true estimate of family history in CH, we conducted a systematic review and meta-analysis of previously published data. METHODS: Our systematic review involved a search of electronic databases (Medline, EMBASE, PubMed, CINAHL) to identify and appraise studies of interest utilising the PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analysis) guidelines. To further ameliorate the accuracy of our analysis we included an additional unpublished cohort of CH patients recruited at a tertiary referral centre for headache, who underwent detailed family history with diagnostic verification in relatives. Data was extracted and meta-analysis conducted to provide a true estimation of family history. RESULTS: In total, we identified 7 studies which fulfilled our inclusion criteria. The estimated true prevalence of CH patients with a positive family history was 6.27% (95% CI:4.65-8.40%) with an overall I2 of 73%. Fitted models for gender subgroups showed higher estimates 9.26% (95% CI: 6.29-13.43%) in females. However the I2 for the female model was 58.42% and significant (pâ=â0.047). CONCLUSION: Our findings estimate a rate of family history in CH to be approximately 6.27% (95% CI: 4.65-8.40%). While estimates were larger for female probands, we demonstrated high heterogeneity in this subgroup. These findings further support a genetic role in the aetiology of CH
R1352Q CACNA1A Variant in a Patient with Sporadic Hemiplegic Migraine, Ataxia, Seizures and Cerebral Oedema: A Case Report
Mutations in the CACNA1A gene show a wide range of neurological phenotypes including hemiplegic migraine, ataxia, mental retardation and epilepsy. In some cases, hemiplegic migraine attacks can be triggered by minor head trauma and culminate in encephalopathy and cerebral oedema. A 37-year-old male without a family history of complex migraine experienced hemiplegic migraine attacks from childhood. The attacks were usually triggered by minor head trauma, and on several occasions complicated with encephalopathy and cerebral oedema. Genetic testing of the proband and unaffected parents revealed a de novo heterozygous nucleotide missense mutation in exon 25 of the CACNA1A gene (c.4055G>A, p.R1352Q). The R1352Q CACNA1A variant shares the phenotype with other described CACNA1A mutations and highlights the interesting association of trauma as a precipitant for hemiplegic migraine. Subjects with early-onset sporadic hemiplegic migraine triggered by minor head injury or associated with seizures, ataxia or episodes of encephalopathy should be screened for mutations. These patients should also be advised to avoid activities that may result in head trauma, and anticonvulsants should be considered as prophylactic migraine therapy
Field Theory Entropy, the -theorem and the Renormalization Group
We consider entropy and relative entropy in Field theory and establish
relevant monotonicity properties with respect to the couplings. The relative
entropy in a field theory with a hierarchy of renormalization group fixed
points ranks the fixed points, the lowest relative entropy being assigned to
the highest multicritical point. We argue that as a consequence of a
generalized theorem Wilsonian RG flows induce an increase in entropy and
propose the relative entropy as the natural quantity which increases from one
fixed point to another in more than two dimensions.Comment: 25 pages, plain TeX (macros included), 6 ps figures. Addition in
title. Entropy of cutoff Gaussian model modified in section 4 to avoid a
divergence. Therefore, last figure modified. Other minor changes to improve
readability. Version to appear in Phys. Rev.
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