183 research outputs found
8-[(1E)-1-(2-AminophenylÂiminio)ethÂyl]-2-oxo-2H-chromen-7-olate
The title Schiff base, C17H14N2O3, exists as an NH tautomer with the H atom of the phenol group transferred to the imine N atom. The iminium H atom is involved in a strong intraÂmolecular N+âHâŻOâ hydrogen bond to the phenolate O atom, forming an S(6) motif. In the crystal structure, NâHâŻO hydrogen bonds form a C(9) chain parallel to [100] and a C(11) chain parallel to [010], while CâHâŻO hydrogen bonds form a C(11) chain parallel to [010]. The combination of NâHâŻO and CâHâŻO hydrogen bonds generates R
4
3(30) rings parallel to the ab plan
Development of Hot Equal Channel Angular Processing (ECAP) consolidation technique in the production of Boron Carbide(B4C)-Reinforced Aluminium Chip (AA6061)-based composite
The production of metal matrix composites (MMCs) through recycled materials is a cost-saving process. However, the
improvement of the mechanical and physical properties is another challenge to be concerned. In this study, recycled aluminium 6061
(AA6061) chips reinforced with different volumetric fractions of boron carbide (B4C) were produced through hot equal channel angular
processing (ECAP). Response surface methodology (RSM) was carried out to investigate the dependent response (compressive strength)
with independent parameters such as different volumetric fractions (5-15%) of added contents of B4C and preheating temperature (450
â 550°C). Also, the number of passes were examined to check the effect on the mechanical and physical properties of the developed recycled
AA6061/B4C composite. The results show that maximum compressive strength and hardness of recycled AA6061/B4C were 59.2 MPa and
69 HV respectively at 5% of B4C contents. Likewise, the density and number of pores increased, which were confirmed through scanning
electron microscope (SEM) and atomic force microscopes (AFM) analysis. However, the number of passes enhanced the mechanical and
physical properties of the recycled AA6061/B4C composite. Therefore, the maximum compressive strength and hardness achieved were
158 MPa and 74.95 HV for the 4th pass. Moreover, the physical properties of recycled AA6061/B4C composite become denser of 2.62 g/cm3
at the 1st pass and 2.67 g/cm3 for the 4th pass. Thus, it can be concluded that the B4C volumetric fraction and number of passes have a
significant effect on recycled AA6061 chips
Quantum entanglement and disentanglement of multi-atom systems
We present a review of recent research on quantum entanglement, with special
emphasis on entanglement between single atoms, processing of an encoded
entanglement and its temporary evolution. Analysis based on the density matrix
formalism are described. We give a simple description of the entangling
procedure and explore the role of the environment in creation of entanglement
and in disentanglement of atomic systems. A particular process we will focus on
is spontaneous emission, usually recognized as an irreversible loss of
information and entanglement encoded in the internal states of the system. We
illustrate some certain circumstances where this irreversible process can in
fact induce entanglement between separated systems. We also show how
spontaneous emission reveals a competition between the Bell states of a two
qubit system that leads to the recently discovered "sudden" features in the
temporal evolution of entanglement. An another problem illustrated in details
is a deterministic preparation of atoms and atomic ensembles in long-lived
stationary squeezed states and entangled cluster states. We then determine how
to trigger the evolution of the stable entanglement and also address the issue
of a steered evolution of entanglement between desired pairs of qubits that can
be achieved simply by varying the parameters of a given system.Comment: Review articl
Medication adherence among diabetic and hypertensive patients in Al-Qassim region of Saudi Arabia
Non-adherence to medication is often an unrecognized risk factor that contributes to failure of the therapeutic plan. The purpose of the study was to identify factors related to high, medium and low medication adherence among adult Saudi patients with hypertension and diabetes mellitus. This study is designed as a descriptive cross sectional survey and was conducted in three tertiary care hospitals of Al-Qassim province of Saudi Arabia. The data was collected using the 8-item Morisky Medication Adherence Scale (MMAS-8) and analyzed by SPSS. Three levels of adherence were considered based on the following scores: 0 to <6 (low); 6 to <8 (medium); 8 (high). Of the 396 patients interviewed, 52% reported low adherence to prescribed medication. Multinomial logistic regression analysis was conducted. Gender, age, literacy level, duration of illness and type of chronic disease were negatively associated with medication adherence. The study shows very high proportion of low and medium adherence on long term medication, which may be responsible for the failure of achieving therapeutic outcome. Further investigation is required to evaluate the applicability of MMAS-8 as a tool of measuring medication adherence among Saudi patients with chronic diseases. Adherence enhancing strategies should also be evaluated in separate patients group
PRUNE is crucial for normal brain development and mutated in microcephaly with neurodevelopmental impairment.
PRUNE is a member of the DHH (Asp-His-His) phosphoesterase protein superfamily of molecules important for cell motility, and implicated in cancer progression. Here we investigated multiple families from Oman, India, Iran and Italy with individuals affected by a new autosomal recessive neurodevelopmental and degenerative disorder in which the cardinal features include primary microcephaly and profound global developmental delay. Our genetic studies identified biallelic mutations of PRUNE1 as responsible. Our functional assays of disease-associated variant alleles revealed impaired microtubule polymerization, as well as cell migration and proliferation properties, of mutant PRUNE. Additionally, our studies also highlight a potential new role for PRUNE during microtubule polymerization, which is essential for the cytoskeletal rearrangements that occur during cellular division and proliferation. Together these studies define PRUNE as a molecule fundamental for normal human cortical development and define cellular and clinical consequences associated with PRUNE mutation
Genomic and Expression Analyses Define MUC17 and PCNX1 as Predictors of Chemotherapy Response in Breast Cancer
Applications of yeast flocculation in biotechnological processes
A review on the main aspects associated with yeast flocculation and its application
in biotechnological processes is presented. This subject is addressed following three
main aspects â the basics of yeast flocculation, the development of ânewâ flocculating yeast
strains and bioreactor development. In what concerns the basics of yeast flocculation, the
state of the art on the most relevant aspects of mechanism, physiology and genetics of yeast
flocculation is reported. The construction of flocculating yeast strains includes not only the
recombinant constitutive flocculent brewerâs yeast, but also recombinant flocculent yeast
for lactose metabolisation and ethanol production. Furthermore, recent work on the
heterologous ÎČ-galactosidase production using a recombinant flocculent Saccharomyces
cerevisiae is considered. As bioreactors using flocculating yeast cells have particular properties,
mainly associated with a high solid phase hold-up, a section dedicated to its operation is
presented. Aspects such as bioreactor productivity and culture stability as well as bioreactor
hydrodynamics and mass transfer properties of flocculating cell cultures are considered.
Finally, the paper concludes describing some of the applications of high cell density
flocculation bioreactors and discussing potential new uses of these systems.Fundação para a CiĂȘncia e a Tecnologia (FCT) â PRAXIS XXI - BD11306/97
Validation of an iPad activity to measure preschool childrenâs food and physical activity knowledge and preferences
Identification of Small Molecule Inhibitors of Pseudomonas aeruginosa Exoenzyme S Using a Yeast Phenotypic Screen
Pseudomonas aeruginosa is an opportunistic human pathogen that is a key factor in the mortality of cystic fibrosis patients, and infection represents an increased threat for human health worldwide. Because resistance of Pseudomonas aeruginosa to antibiotics is increasing, new inhibitors of pharmacologically validated targets of this bacterium are needed. Here we demonstrate that a cell-based yeast phenotypic assay, combined with a large-scale inhibitor screen, identified small molecule inhibitors that can suppress the toxicity caused by heterologous expression of selected Pseudomonas aeruginosa ORFs. We identified the first small molecule inhibitor of Exoenzyme S (ExoS), a toxin involved in Type III secretion. We show that this inhibitor, exosin, modulates ExoS ADP-ribosyltransferase activity in vitro, suggesting the inhibition is direct. Moreover, exosin and two of its analogues display a significant protective effect against Pseudomonas infection in vivo. Furthermore, because the assay was performed in yeast, we were able to demonstrate that several yeast homologues of the known human ExoS targets are likely ADP-ribosylated by the toxin. For example, using an in vitro enzymatic assay, we demonstrate that yeast Ras2p is directly modified by ExoS. Lastly, by surveying a collection of yeast deletion mutants, we identified Bmh1p, a yeast homologue of the human FAS, as an ExoS cofactor, revealing that portions of the bacterial toxin mode of action are conserved from yeast to human. Taken together, our integrated cell-based, chemical-genetic approach demonstrates that such screens can augment traditional drug screening approaches and facilitate the discovery of new compounds against a broad range of human pathogens
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