Integrated cost-benefit analysis of tsetse control and herd productivity to inform control programs for animal African trypanosomiasis

Animal African trypanosomiasis (AAT) and its tsetse vector are responsible for annual losses estimated in billions of US dollars ($). Recent years have seen the implementation of a series of multinational interventions. However, actors of AAT control face complex resource allocation decisions due to the geographical range of AAT, diversity of ecological and livestock systems, and range of control methods available. The study presented here integrates an existing tsetse abundance model with a bio-economic herd model that captures local production characteristics as well as heterogeneities in AAT incidence and breed. These models were used to predict the impact of tsetse elimination on the net value of cattle production in the districts of Mambwe, in Zambia, and Faro et Déo in Cameroon. The net value of cattle production under the current situation was used as a baseline, and compared with alternative publicly funded control programmes. In Zambia, the current baseline is AAT control implemented privately by cattle owners (Scenario Z0). In Cameroon, the baseline (Scenario C0) is a small-scale publicly funded tsetse control programme and privately funded control at farm level. The model was run for 10 years, using a discount rate of 5%

A Geometrical Method of Decoupling

The computation of tunes and matched beam distributions are essential steps in the analysis of circular accelerators. If certain symmetries - like midplane symmetrie - are present, then it is possible to treat the betatron motion in the horizontal, the vertical plane and (under certain circumstances) the longitudinal motion separately using the well-known Courant-Snyder theory, or to apply transformations that have been described previously as for instance the method of Teng and Edwards. In a preceeding paper it has been shown that this method requires a modification for the treatment of isochronous cyclotrons with non-negligible space charge forces. Unfortunately the modification was numerically not as stable as desired and it was still unclear, if the extension would work for all thinkable cases. Hence a systematic derivation of a more general treatment seemed advisable. In a second paper the author suggested the use of real Dirac matrices as basic tools to coupled linear optics and gave a straightforward recipe to decouple positive definite Hamiltonians with imaginary eigenvalues. In this article this method is generalized and simplified in order to formulate a straightforward method to decouple Hamiltonian matrices with eigenvalues on the real and the imaginary axis. It is shown that this algebraic decoupling is closely related to a geometric "decoupling" by the orthogonalization of the vectors $\vec E$, $\vec B$ and $\vec P$, that were introduced with the so-called "electromechanical equivalence". We present a structure-preserving block-diagonalization of symplectic or Hamiltonian matrices, respectively. When used iteratively, the decoupling algorithm can also be applied to n-dimensional systems and requires ${\cal O}(n^2)$ iterations to converge to a given precision.Comment: 13 pages, 1 figur

A Frustrated 3-Dimensional Antiferromagnet: Stacked J1−J2J_{1}-J_{2} Layers

We study a frustrated 3D antiferromagnet of stacked $J_1 - J_2$ layers. The intermediate 'quantum spin liquid' phase, present in the 2D case, narrows with increasing interlayer coupling and vanishes at a triple point. Beyond this there is a direct first-order transition from N{\' e}el to columnar order. Possible applications to real materials are discussed.Comment: 11 pages,7 figure

Simplified liquid oxygen propellant conditioning concepts

Current liquid oxygen feed systems waste propellant and use hardware, unnecessary during flight, to condition the propellant at the engine turbopumps prior to launch. Simplified liquid oxygen propellant conditioning concepts are being sought for future launch vehicles. During a joint program, four alternative propellant conditioning options were studied: (1) passive recirculation; (2) low bleed through the engine; (3) recirculation lines; and (4) helium bubbling. The test configuration for this program was based on a vehicle design which used a main recirculation loop that was insulated on the downcomer and uninsulated on the upcomer. This produces a natural convection recirculation flow. The test article for this program simulated a feedline which ran from the main recirculation loop to the turbopump. The objective was to measure the temperature profile of this test article. Several parameters were varied from the baseline case to determine their effects on the temperature profile. These parameters included: flow configuration, feedline slope, heat flux, main recirculation loop velocity, pressure, bleed rate, helium bubbling, and recirculation lines. The heat flux, bleed rate, and recirculation configurations produced the greatest changes from the baseline temperature profile. However, the temperatures in the feedline remained subcooled. Any of the options studied could be used in future vehicles

A comparative investigation of the efficacy of CO2 and high power diode lasers for the forming of EN3 mild steel sheets

A comparative investigation of the effectiveness of a high power diode laser (HPDL) and a CO2 laser for the forming of thin section EN3 mild steel sheet has been conducted. The buckling mechanism was identified as the laser forming mechanism responsible for the induced bending. For both lasers it was found that the induced bending angles increased with an increasing number of irradiations and high laser powers, whilst decreasing as the traverse speed was increased. Also, it was apparent from the experimental results that the laser bending angle was only linearly proportional to the number of irradiations when the latter was small due to local material thickening along the bend edge with a high number of irradiations. Owing to the mild steel’s greater beam absorption at the HPDL wavelength, larger bending angles were induced when using the HPDL. However, under certain conditions the performance of the CO2 laser in terms of induced bending angle was seen to approach that of the HPDL. Nevertheless, similar results between the two lasers were only achieved with increasing irradiations, thus it was concluded that the efficacy of the HPDL was higher than that of the CO2 laser insofar as it was more efficient. From graphical results and the employment of an analytical procedure, the laser line energy range in which accurate control of the HPDL bending of the mild steel sheets could be exercised efficiently was found to be 53 J mm-1 < P/v < 78 J mm-1, whilst for the CO2 laser the range was 61 J mm-1 < P/v < 85 J mm-1

An efficient hardware architecture for a neural network activation function generator

This paper proposes an efficient hardware architecture for a function generator suitable for an artificial neural network (ANN). A spline-based approximation function is designed that provides a good trade-off between accuracy and silicon area, whilst also being inherently scalable and adaptable for numerous activation functions. This has been achieved by using a minimax polynomial and through optimal placement of the approximating polynomials based on the results of a genetic algorithm. The approximation error of the proposed method compares favourably to all related research in this field. Efficient hardware multiplication circuitry is used in the implementation, which reduces the area overhead and increases the throughput

Towards sustainable healthcare system performance in the 21st century in high-income countries: A protocol for a systematic review of the grey literature

© © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. Introduction There is wide recognition that, if healthcare systems continue along current trajectories, they will become harder to sustain. Ageing populations, accelerating rates of chronic disease, increasing costs, inefficiencies, wasteful spending and low-value care pose significant challenges to healthcare system durability. Sustainable healthcare systems are important to patients, society, policy-makers, public and private funders, the healthcare workforce and researchers. To capture current thinking about improving healthcare system sustainability, we present a protocol for the systematic review of grey literature to capture the current state-of-knowledge and to compliment a review of peer-reviewed literature. Methods and analysis The proposed search strategy, based on the Preferred Reporting Items for Systematic Review and Meta-Analyses guidelines, includes Google Advanced Search, snowballing techniques and targeted hand searching of websites of lead organisations such as WHO, Organisation for Economic Cooperation and Development, governments, public policy institutes, universities and non-government organisations. Documents will be selected after reviewing document summaries. Included documents will undergo full-Text review. The following criteria will be used: grey literature document; English language; published January 2013-March 2018; relevant to the healthcare delivery system; the content has international or national scope in high-income countries. Documents will be assessed for quality, credibility and objectivity using validated checklists. Descriptive data elements will be extracted: identified sustainability threats, definitions of sustainability, attributes of sustainable healthcare systems, solutions for improvement and outcome measures of sustainability. Data will be analysed using novel text-mining methods to identify common concept themes and meanings. This will be triangulated with the more traditional analysis and concept theming by the researchers. Ethics and dissemination No primary data will be collected, therefore ethical approval will not be sought. The results will be disseminated in peer-reviewed literature, as conference presentations and as condensed summaries for policy-makers and health system partners. PROSPERO registration number CRD42018103076

Covariation Among Vowel Height Effects on Acoustic Measures

Covariation among vowel height effects on vowel intrinsic fundamental frequency (IF0), voice onset time (VOT), and voiceless interval duration (VID) is analyzed to assess the plausibility of a common physiological mechanism underlying variation in these measures. Phrases spoken by 20 young adults, containing words composed of initial voiceless stops or /s/ and high or low vowels, were produced in habitual and voluntarily increased F0 conditions. High vowels were associated with increased IF0 and longer VIDs. VOT and VID exhibited significant covariation with IF0 only for males at habitua

REACTIVITY OF CHLOROPHYLL a/b-PROTEINS AND MICELLAR TRITON X-100 COMPLEXES OF CHLOROPHYLLS a OR b WITH BOROHYDRIDE

The reaction of several plant chlorophyll-protein complexes with NaBH4 has been studied by absorption spectroscopy. In all the complexes studied, chlorophyll b is more reactive than Chi a, due to preferential reaction of its formyl substituent at C-7. The complexes also show large variations in reactivity towards NaBH4 and the order of reactivity is: LHCI > PSII complex > LHCII > PSI > P700 (investigated as a component of PSI). Differential pools of the same type of chlorophyll have been observed in several complexes. Parallel work was undertaken on the reactivity of micellar complexes of chlorophyll a and of chlorophyll b with NaBH4 to study the effect of aggregation state on this reactivity. In these complexes, both chlorophyll a and b show large variations in reactivity in the order monomer > oligomer > polymer with chlorophyll b generally being more reactive than chlorophyll a. It is concluded that aggregation decreases the reactivity of chlorophylls towards NaBH4 in vitro, and may similarly decrease reactivity in naturally-occurring chlorophyll-protein complexes