4,496 research outputs found
The antigenic index: a novel algorithm for predicting antigenic determinants
In this paper, we introduce a computer algorithm which can
be used to predict the topological features of a protein directly
from its primary amino acid sequence. The computer program
generates values for surface accessibility parameters and combines
these values with those obtained for regional backbone
flexibility and predicted secondary structure. The output of this
algorithm, the antigenic index, is used to create a linear surface
contour profile of the protein. Because most, if not all,
antigenic sites are located within surface exposed regions of
a protein, the program offers a reliable means of predicting
potential antigenic determinants. We have tested the ability of
this program to generate accurate surface contour profiles and
predict antigenic sites from the linear amino acid sequences
of well-characterized proteins and found a strong correlation
between the predictions of the antigenic index and known structural
and biological data
Requirements for multidisciplinary design of aerospace vehicles on high performance computers
The design of aerospace vehicles is becoming increasingly complex as the various contributing disciplines and physical components become more tightly coupled. This coupling leads to computational problems that will be tractable only if significant advances in high performance computing systems are made. Some of the modeling, algorithmic and software requirements generated by the design problem are discussed
The Effect of Tax Laws and the Cost of Capital on the Size of Newly Constructed Strip Shopping Centers
While the impact of tax policy and other economic variables on the total amount of construction has been widely studied, this paper proposes that these variables also affect the size distribution of the properties constructed. The basic intuition is that there is a lower bound to the economically feasible size of a project due to economies of scale in construction. Events favorable to construction, such as lower interest rates and more favorable tax treatment, relax this lower bound permitting the construction of smaller properties. We test this proposition using data on newly constructed neighborhood shopping centers in Clark County, Nevada during the period from 1971 to 1999.
Roberts v. United States Jaycees: Discriminatory Membership Policy of a National Organization Held Not Protected by First Amendment Freedom of Association
Roberts v. United States Jaycees: Discriminatory Membership Policy of a National Organization Held Not Protected by First Amendment Freedom of Association
An improved viscid/inviscid interaction procedure for transonic flow over airfoils
A new interacting boundary layer approach for computing the viscous transonic flow over airfoils is described. The theory includes a complete treatment of viscous interaction effects induced by the wake and accounts for normal pressure gradient effects across the boundary layer near trailing edges. The method is based on systematic expansions of the full Reynolds equation of turbulent flow in the limit of Reynolds numbers, Reynolds infinity. Procedures are developed for incorporating the local trailing edge solution into the numerical solution of the coupled full potential and integral boundary layer equations. Although the theory is strictly applicable to airfoils with cusped or nearly cusped trailing edges and to turbulent boundary layers that remain fully attached to the airfoil surface, the method was successfully applied to more general airfoils and to flows with small separation zones. Comparisons of theoretical solutions with wind tunnel data indicate the present method can accurately predict the section characteristics of airfoils including the absolute levels of drag
A Quantitative Ecological Assessment of Diving Sites in the Egyptian Red Sea During a Period of Severe Anchor Damage: A Baseline for Restoration and Sustainable Tourism Management
Ideologies of time: How elite corporate actors engage the future
Our paper deals with how elite corporate actors in a Western capitalist-democratic society conceive of and prepare for the future. Paying attention to how senior officers of ten important Danish companies make sense of the future will help us to identify how particular temporal narratives are ideologically marked. This ideological dimension offers a common sense frame that is structured around a perceived inevitability of capitalism, a market economy as the basic organizational structure of the social and economic order, and an assumption of confident access to the future. Managers envisage their organization?s future and make plans for organizational action in a space where ?business as usual? reigns, and there is little engagement with the future as fundamentally open; as a time-yet-to-come. In using a conceptual lens inspired by the work of Fredric Jameson, we first explore the details of this presentism and a particular colonization of the future, and then linger over small disruptions in the narratives of our interviewees which point to what escapes or jars their common sense frame, explore the implicit meanings they assign to their agency, and also find clues and traces of temporal actions and strategies in their narratives that point to a subtly different engagement with time
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